Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110672216> ?p ?o ?g. }
- W3110672216 abstract "Sirtuins, NAD + dependent proteins belonging to class III histone deacetylases, are involved in regulating numerous cellular processes including cellular stress, insulin resistance, inflammation, mitochondrial biogenesis, chromatin silencing, cell cycle regulation, transcription, and apoptosis. Of the seven mammalian sirtuins present in humans, Sirt6 is an essential nuclear sirtuin. Until recently, Sirt6 was thought to regulate chromatin silencing, but new research indicates its role in aging, diabetes, cardiovascular disease, lipid metabolism, neurodegenerative diseases, and cancer. Various murine models demonstrate that Sirt6 activation is beneficial in alleviating many disease conditions and increasing lifespan, showing that Sirt6 is a critical therapeutic target in the treatment of various disease conditions in humans. Sirt6 also regulates the pathogenesis of multiple diseases by acting on histone proteins and non-histone proteins. Endogenous and non-endogenous modulators regulate both activation and inhibition of Sirt6. Few Sirt6 specific non-endogenous modulators have been identified. Hence the identification of Sirt6 specific modulators may have potential therapeutic roles in the diseases described above. In this review, we describe the development of Sirt6, the role it plays in the human condition, the functional role and therapeutic importance in disease processes, and specific modulators and molecular mechanism of Sirt6 in the regulation of metabolic homeostasis, cardiovascular disease, aging, and neurodegenerative disease." @default.
- W3110672216 created "2020-12-21" @default.
- W3110672216 creator A5025170569 @default.
- W3110672216 creator A5054077622 @default.
- W3110672216 creator A5064238194 @default.
- W3110672216 creator A5088880493 @default.
- W3110672216 date "2020-12-07" @default.
- W3110672216 modified "2023-10-12" @default.
- W3110672216 title "Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease" @default.
- W3110672216 cites W1199728507 @default.
- W3110672216 cites W1579391006 @default.
- W3110672216 cites W1848301660 @default.
- W3110672216 cites W1920609417 @default.
- W3110672216 cites W1972924731 @default.
- W3110672216 cites W1973327581 @default.
- W3110672216 cites W1979153753 @default.
- W3110672216 cites W1983904065 @default.
- W3110672216 cites W1984818641 @default.
- W3110672216 cites W1988622943 @default.
- W3110672216 cites W1992494733 @default.
- W3110672216 cites W1994540097 @default.
- W3110672216 cites W2001377421 @default.
- W3110672216 cites W2007666596 @default.
- W3110672216 cites W2012885541 @default.
- W3110672216 cites W2012895942 @default.
- W3110672216 cites W2016656923 @default.
- W3110672216 cites W2020311873 @default.
- W3110672216 cites W2026102269 @default.
- W3110672216 cites W2026355845 @default.
- W3110672216 cites W2029969982 @default.
- W3110672216 cites W2031320526 @default.
- W3110672216 cites W2032983681 @default.
- W3110672216 cites W2033958147 @default.
- W3110672216 cites W2034204409 @default.
- W3110672216 cites W2034641256 @default.
- W3110672216 cites W2042716686 @default.
- W3110672216 cites W2051170391 @default.
- W3110672216 cites W2054866841 @default.
- W3110672216 cites W2055107976 @default.
- W3110672216 cites W2056078632 @default.
- W3110672216 cites W2061576857 @default.
- W3110672216 cites W2063084036 @default.
- W3110672216 cites W2077750876 @default.
- W3110672216 cites W2078340601 @default.
- W3110672216 cites W2079481037 @default.
- W3110672216 cites W2081912023 @default.
- W3110672216 cites W2083953609 @default.
- W3110672216 cites W2086453930 @default.
- W3110672216 cites W2096161049 @default.
- W3110672216 cites W2099419173 @default.
- W3110672216 cites W2105812111 @default.
- W3110672216 cites W2106561187 @default.
- W3110672216 cites W2109560454 @default.
- W3110672216 cites W2118964113 @default.
- W3110672216 cites W2129488204 @default.
- W3110672216 cites W2131289471 @default.
- W3110672216 cites W2131972618 @default.
- W3110672216 cites W2134390575 @default.
- W3110672216 cites W2134718821 @default.
- W3110672216 cites W2135071783 @default.
- W3110672216 cites W2137289528 @default.
- W3110672216 cites W2142983739 @default.
- W3110672216 cites W2144137526 @default.
- W3110672216 cites W2146019031 @default.
- W3110672216 cites W2154362103 @default.
- W3110672216 cites W2157271021 @default.
- W3110672216 cites W2166613336 @default.
- W3110672216 cites W2167711201 @default.
- W3110672216 cites W2168702014 @default.
- W3110672216 cites W2172818274 @default.
- W3110672216 cites W2175544344 @default.
- W3110672216 cites W2181797758 @default.
- W3110672216 cites W2190916947 @default.
- W3110672216 cites W2234950399 @default.
- W3110672216 cites W2280212630 @default.
- W3110672216 cites W2294539478 @default.
- W3110672216 cites W2294575394 @default.
- W3110672216 cites W2294654701 @default.
- W3110672216 cites W2300480290 @default.
- W3110672216 cites W2302321360 @default.
- W3110672216 cites W2327558844 @default.
- W3110672216 cites W2332232004 @default.
- W3110672216 cites W2336367970 @default.
- W3110672216 cites W2336483756 @default.
- W3110672216 cites W2345900051 @default.
- W3110672216 cites W2346588390 @default.
- W3110672216 cites W2398849529 @default.
- W3110672216 cites W2408218863 @default.
- W3110672216 cites W2412991703 @default.
- W3110672216 cites W2414776985 @default.
- W3110672216 cites W2415755712 @default.
- W3110672216 cites W2464287880 @default.
- W3110672216 cites W2505624008 @default.
- W3110672216 cites W2510888821 @default.
- W3110672216 cites W2516969557 @default.
- W3110672216 cites W2519315912 @default.
- W3110672216 cites W2522309832 @default.
- W3110672216 cites W2548287959 @default.
- W3110672216 cites W2550281359 @default.
- W3110672216 cites W2552184863 @default.