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- W3110683966 abstract "Abstract Background New therapeutic agents are being developed that target not only the amyloid plaques in Alzheimer’s disease (AD), but also the extracellular p‐tau aggregates, Aβ‐metal induced oxidative stress, and neuroinflammation. Method We have developed two novel multifunctional compounds (MFC) that exhibit high binding affinity for Aβ aggregates ‐ including soluble Aβ oligomers, and a series of ex vivo and in vivo immunostaining and imaging studies were employed to probe the beneficial properties of these MFCs. Result Upon treatment of 5 × FAD mice with one of the MFC, fluorescence imaging of the brain sections shows that the MFC can easily penetrate the blood‐brain‐barrier and selectively bind to the Aβ oligomers, as confirmed by the colocalization with an Aβ oligomer‐specific antibody. Furthermore, when comparing the MFC‐treated mice vs. the vehicle‐treated mice, the total amount of Aβ species and the associated p‐tau aggregates was significantly decreased by ∼50%, along with a significant reduction in the amount of activated microglia. Conclusion The multifunctional compounds reported herein can attenuate the formation of amyloid plaques and associated p‐tau aggregates, while also reducing the microglia‐mediated neuroinflammatory response, which is uncommon among the previously reported amyloid‐targeting chemical agents." @default.
- W3110683966 created "2020-12-21" @default.
- W3110683966 creator A5021486550 @default.
- W3110683966 date "2020-12-01" @default.
- W3110683966 modified "2023-09-26" @default.
- W3110683966 title "A multifunctional chemical agent as an attenuator of amyloid and p‐tau burden and neuroinflammation in Alzheimer’s disease" @default.
- W3110683966 doi "https://doi.org/10.1002/alz.047006" @default.
- W3110683966 hasPublicationYear "2020" @default.
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