Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110702970> ?p ?o ?g. }
- W3110702970 abstract "Serine 2 phosphorylation (S2P) within the CTD of RNA polymerase II is considered a Cdk9/Cdk12-dependent mark required for 3'-end processing. However, the relevance of CTD S2P in metazoan development is unknown. We show that cdk-12 lesions or a full-length CTD S2A substitution results in an identical phenotype in Caenorhabditis elegans Embryogenesis occurs in the complete absence of S2P, but the hatched larvae arrest development, mimicking the diapause induced when hatching occurs in the absence of food. Genome-wide analyses indicate that when CTD S2P is inhibited, only a subset of growth-related genes is not properly expressed. These genes correspond to SL2 trans-spliced mRNAs located in position 2 and over within operons. We show that CDK-12 is required for maximal occupancy of cleavage stimulatory factor necessary for SL2 trans-splicing. We propose that CTD S2P functions as a gene-specific signaling mark ensuring the nutritional control of the C. elegans developmental program." @default.
- W3110702970 created "2020-12-21" @default.
- W3110702970 creator A5001751514 @default.
- W3110702970 creator A5005988926 @default.
- W3110702970 creator A5009849184 @default.
- W3110702970 creator A5015397968 @default.
- W3110702970 creator A5031421266 @default.
- W3110702970 creator A5035224172 @default.
- W3110702970 creator A5052592686 @default.
- W3110702970 creator A5054048737 @default.
- W3110702970 creator A5061414099 @default.
- W3110702970 creator A5079472126 @default.
- W3110702970 creator A5090265399 @default.
- W3110702970 date "2020-12-11" @default.
- W3110702970 modified "2023-10-01" @default.
- W3110702970 title "RNA polymerase II CTD S2P is dispensable for embryogenesis but mediates exit from developmental diapause in <i>C. elegans</i>" @default.
- W3110702970 cites W1488258440 @default.
- W3110702970 cites W1520738779 @default.
- W3110702970 cites W1533226924 @default.
- W3110702970 cites W1981930838 @default.
- W3110702970 cites W1982551833 @default.
- W3110702970 cites W1988650678 @default.
- W3110702970 cites W2005054126 @default.
- W3110702970 cites W2007117154 @default.
- W3110702970 cites W2019725194 @default.
- W3110702970 cites W2022832110 @default.
- W3110702970 cites W2032033331 @default.
- W3110702970 cites W2032188321 @default.
- W3110702970 cites W2032742580 @default.
- W3110702970 cites W2032983754 @default.
- W3110702970 cites W2035707307 @default.
- W3110702970 cites W2037237823 @default.
- W3110702970 cites W2047495081 @default.
- W3110702970 cites W2049017158 @default.
- W3110702970 cites W2049220511 @default.
- W3110702970 cites W2049614203 @default.
- W3110702970 cites W2054084236 @default.
- W3110702970 cites W2057575035 @default.
- W3110702970 cites W2057645113 @default.
- W3110702970 cites W2058262378 @default.
- W3110702970 cites W2059362435 @default.
- W3110702970 cites W2060323540 @default.
- W3110702970 cites W2078525643 @default.
- W3110702970 cites W2097344907 @default.
- W3110702970 cites W2101424708 @default.
- W3110702970 cites W2102278945 @default.
- W3110702970 cites W2103988034 @default.
- W3110702970 cites W2105775411 @default.
- W3110702970 cites W2106774938 @default.
- W3110702970 cites W2109684789 @default.
- W3110702970 cites W2116313207 @default.
- W3110702970 cites W2116402680 @default.
- W3110702970 cites W2117800899 @default.
- W3110702970 cites W2118585964 @default.
- W3110702970 cites W2121649903 @default.
- W3110702970 cites W2123072999 @default.
- W3110702970 cites W2123335587 @default.
- W3110702970 cites W2123814549 @default.
- W3110702970 cites W2129874580 @default.
- W3110702970 cites W2131271579 @default.
- W3110702970 cites W2132654115 @default.
- W3110702970 cites W2135869142 @default.
- W3110702970 cites W2136446084 @default.
- W3110702970 cites W2138207763 @default.
- W3110702970 cites W2141712551 @default.
- W3110702970 cites W2147390648 @default.
- W3110702970 cites W2148396765 @default.
- W3110702970 cites W2151746105 @default.
- W3110702970 cites W2153722106 @default.
- W3110702970 cites W2160720092 @default.
- W3110702970 cites W2170551349 @default.
- W3110702970 cites W2179438025 @default.
- W3110702970 cites W2318322110 @default.
- W3110702970 cites W2324768452 @default.
- W3110702970 cites W2344338654 @default.
- W3110702970 cites W2352139208 @default.
- W3110702970 cites W2426703678 @default.
- W3110702970 cites W2519475315 @default.
- W3110702970 cites W2789082409 @default.
- W3110702970 cites W2831542631 @default.
- W3110702970 cites W2909524758 @default.
- W3110702970 cites W2913941753 @default.
- W3110702970 cites W3008156371 @default.
- W3110702970 doi "https://doi.org/10.1126/sciadv.abc1450" @default.
- W3110702970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7725455" @default.
- W3110702970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33298437" @default.
- W3110702970 hasPublicationYear "2020" @default.
- W3110702970 type Work @default.
- W3110702970 sameAs 3110702970 @default.
- W3110702970 citedByCount "7" @default.
- W3110702970 countsByYear W31107029702022 @default.
- W3110702970 countsByYear W31107029702023 @default.
- W3110702970 crossrefType "journal-article" @default.
- W3110702970 hasAuthorship W3110702970A5001751514 @default.
- W3110702970 hasAuthorship W3110702970A5005988926 @default.
- W3110702970 hasAuthorship W3110702970A5009849184 @default.
- W3110702970 hasAuthorship W3110702970A5015397968 @default.
- W3110702970 hasAuthorship W3110702970A5031421266 @default.
- W3110702970 hasAuthorship W3110702970A5035224172 @default.
- W3110702970 hasAuthorship W3110702970A5052592686 @default.