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• W3110707966 endingPage "108361" @default.
• W3110707966 startingPage "108361" @default.
• W3110707966 abstract "Approximately 165,000 and 311,000 individuals die annually from urothelial (UC) and cervical (CC) cancer. The therapeutic success of these cancers depends strongly on their early detection and could be improved by use of additional diagnostic tools. We evaluated the current knowledge of the use of micronucleus (MN) assays (which detect structural and numerical chromosomal aberrations) with urine- (UDC) and cervix-derived (CDC) cells for the identification of humans with increased risks and for the diagnosis of UC and CC. Several findings indicate that MN rates in UDC are higher in individuals with inflammation and schistosomiasis that are associated with increased prevalence of UC; furthermore, higher MN rates were also found in CDC in women with HPV, Candidiasis and Trichomonas infections which increase the risks for CC. Only few studies were published on MN rates in UDS in patients with UC, two concern the detection of recurrent bladder tumors. Strong correlations were found in individuals with abnormal CC cells that are scored in Pap tests and histopathological abnormalities. In total, 16 studies were published which concerned these topics. MN rates increased in the order: inflammation < ASC-US/ASC-H < LSIL < HSIL < CC. It is evident that MNi numbers increase with the risk to develop CC and with the degree of malignant transformation. Overall, the evaluation of the literature indicates that MNi are useful additional biomarkers for the prognosis and detection of CC and possibly also for UC. In regard to the diagnosis/surveillance of UC, further investigations are needed to draw firm conclusions, but the currently available data are promising. In general, further standardization of the assays is needed (i.e. definition of optimal cell numbers and of suitable stains as well as elucidation of the usefulness of parameters reflecting cytotoxicity and mitotic activity) before MN trials can be implemented in routine screening." @default.
• W3110707966 created "2020-12-21" @default.
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• W3110707966 date "2021-01-01" @default.
• W3110707966 modified "2023-09-27" @default.
• W3110707966 title "Impact of infections, preneoplasia and cancer on micronucleus formation in urothelial and cervical cells: A systematic review" @default.
• W3110707966 cites W1512345474 @default.
• W3110707966 cites W1515495812 @default.
• W3110707966 cites W1517095006 @default.
• W3110707966 cites W1958972396 @default.
• W3110707966 cites W1963623377 @default.
• W3110707966 cites W1964062075 @default.
• W3110707966 cites W1965955148 @default.
• W3110707966 cites W1968261842 @default.
• W3110707966 cites W1970308836 @default.
• W3110707966 cites W1971855584 @default.
• W3110707966 cites W1972814756 @default.
• W3110707966 cites W1974885582 @default.
• W3110707966 cites W1980890104 @default.
• W3110707966 cites W1995817776 @default.
• W3110707966 cites W1996621285 @default.
• W3110707966 cites W1999585879 @default.
• W3110707966 cites W2002405772 @default.
• W3110707966 cites W2005036082 @default.
• W3110707966 cites W2005285597 @default.
• W3110707966 cites W2006157323 @default.
• W3110707966 cites W2014476767 @default.
• W3110707966 cites W2015145465 @default.
• W3110707966 cites W2017065787 @default.
• W3110707966 cites W2019970996 @default.
• W3110707966 cites W2021147488 @default.
• W3110707966 cites W2021615040 @default.
• W3110707966 cites W2024083731 @default.
• W3110707966 cites W2025690460 @default.
• W3110707966 cites W2025809882 @default.
• W3110707966 cites W2026518249 @default.
• W3110707966 cites W2029744908 @default.
• W3110707966 cites W2031251192 @default.
• W3110707966 cites W2032974427 @default.
• W3110707966 cites W2033860910 @default.
• W3110707966 cites W2036350356 @default.
• W3110707966 cites W2042676947 @default.
• W3110707966 cites W2045478021 @default.
• W3110707966 cites W2050448556 @default.
• W3110707966 cites W2053978719 @default.
• W3110707966 cites W2060565226 @default.
• W3110707966 cites W2062782077 @default.
• W3110707966 cites W2068017293 @default.
• W3110707966 cites W2068618828 @default.
• W3110707966 cites W2071316064 @default.
• W3110707966 cites W2071690782 @default.
• W3110707966 cites W2073113564 @default.
• W3110707966 cites W2079467711 @default.
• W3110707966 cites W2081249433 @default.
• W3110707966 cites W2085520064 @default.
• W3110707966 cites W2088402931 @default.
• W3110707966 cites W2092889600 @default.
• W3110707966 cites W2093040983 @default.
• W3110707966 cites W2099325295 @default.
• W3110707966 cites W2107040843 @default.
• W3110707966 cites W2108701553 @default.
• W3110707966 cites W2113351078 @default.
• W3110707966 cites W2117692326 @default.
• W3110707966 cites W2127280826 @default.
• W3110707966 cites W2135367058 @default.
• W3110707966 cites W2135663289 @default.
• W3110707966 cites W2143698860 @default.
• W3110707966 cites W2149816844 @default.
• W3110707966 cites W2151633395 @default.
• W3110707966 cites W2154194181 @default.
• W3110707966 cites W2157432335 @default.
• W3110707966 cites W2157993533 @default.
• W3110707966 cites W2162130153 @default.
• W3110707966 cites W2164130458 @default.
• W3110707966 cites W2165917064 @default.
• W3110707966 cites W2184459005 @default.
• W3110707966 cites W2277335334 @default.
• W3110707966 cites W2305859063 @default.
• W3110707966 cites W2320686397 @default.
• W3110707966 cites W2338158266 @default.
• W3110707966 cites W2396115177 @default.
• W3110707966 cites W2409729188 @default.
• W3110707966 cites W2503481018 @default.
• W3110707966 cites W2519745468 @default.
• W3110707966 cites W2558687427 @default.
• W3110707966 cites W2563146150 @default.
• W3110707966 cites W2588405611 @default.
• W3110707966 cites W2611519536 @default.
• W3110707966 cites W2737813907 @default.

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