FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110753676> ?p ?o ?g. }

• W3110753676 endingPage "113699" @default.
• W3110753676 startingPage "113699" @default.
• W3110753676 abstract "Microbial biofilm formation, a quorum sensing (QS) regulated process, is one of the major causes of nosocomial and chronic infections, foodborne diseases, and associated deaths. Various approaches have been used to eradicate the menace of biofilm. Ethnomedicinal plants as potent antibiofilm agents are gaining a lot of interest in an era where the drug resistance is increasing and the availability of potent antibiotics is no longer promised. In this context, the methanol extract of Cuphea carthagenensis (CCMD), an ethno-medicinal and culinary herb, was evaluated as an antibiofilm and anti-QS agent against Pseudomonas aeruginosa.The aim of the study is to evaluate the antibiofilm and anti-QS activity of an ethnomedicinal plant against a strong biofilm forming microorganism, P. aeruginosa.Antibiofilm activity of CCMD was demonstrated at different concentrations by Tissue Culture Plate, Test Tube method and other microscopic techniques. The effect of CCMD on QS and QS-related virulence factors viz. Pyocyanin, exopolymeric substance matrix (EPS), total protease, elastase, pyoverdin and swimming motility in P. aeruginosa were also evaluated. Antioxidant activity (DPPH & FRAP), total phenolic and flavonoid content were also checked. In order to determine the composition of the extract HPLC analysis was also performed.In vitro study demonstrated a significant inhibition of biofilm formation (81.88 ± 2.57%) as well as production of QS-dependent virulence factors in P. aeruginosa. The extract also inhibited violacein production (83.31 ± 2.77%) in Chromobacterium violaceum which correlates with the reduction in QS-mediated virulence factors. The extract showed 64.79% ± 0.83% DPPH scavenging activity and reduction of ferricyanide complex (Fe3+) to the ferrous form (Fe2+) in DPPH and FRAP assay, respectively. Furthermore, the extract showed thermal stability and does not have any growth inhibitory effect on P. aeruginosa. The HPLC analysis demonstrated the presence of ellagic acid, ascorbic acid and hippuric acid in the extract.This work is the first to demonstrate that C. carthagenensis can attenuate biofilm formation and QS-mediated virulence factors of P. aeruginosa. Further investigation is required to use this ethnomedicinal plant (CCMD) as an important source of antibiofilm agents." @default.
• W3110753676 created "2020-12-21" @default.
• W3110753676 creator A5030729208 @default.
• W3110753676 creator A5045863585 @default.
• W3110753676 creator A5058296735 @default.
• W3110753676 date "2021-04-01" @default.
• W3110753676 modified "2023-09-26" @default.
• W3110753676 title "Inhibition of biofilm and quorum sensing-regulated virulence factors in Pseudomonas aeruginosa by Cuphea carthagenensis (Jacq.) J. F. Macbr. Leaf extract: An in vitro study" @default.
• W3110753676 cites W1151439807 @default.
• W3110753676 cites W1195155422 @default.
• W3110753676 cites W1895206922 @default.
• W3110753676 cites W1899244814 @default.
• W3110753676 cites W1929451968 @default.
• W3110753676 cites W1964478736 @default.
• W3110753676 cites W1965451682 @default.
• W3110753676 cites W1968834637 @default.
• W3110753676 cites W1979737535 @default.
• W3110753676 cites W1983740472 @default.
• W3110753676 cites W1984596253 @default.
• W3110753676 cites W1995866525 @default.
• W3110753676 cites W1996406405 @default.
• W3110753676 cites W2005361874 @default.
• W3110753676 cites W2005502842 @default.
• W3110753676 cites W2044035940 @default.
• W3110753676 cites W2049975798 @default.
• W3110753676 cites W2051935224 @default.
• W3110753676 cites W2056536052 @default.
• W3110753676 cites W2057153376 @default.
• W3110753676 cites W2062501016 @default.
• W3110753676 cites W2065092788 @default.
• W3110753676 cites W2079115010 @default.
• W3110753676 cites W2102131116 @default.
• W3110753676 cites W2115025590 @default.
• W3110753676 cites W2115933619 @default.
• W3110753676 cites W2176975120 @default.
• W3110753676 cites W2206469536 @default.
• W3110753676 cites W2291764541 @default.
• W3110753676 cites W2397493500 @default.
• W3110753676 cites W2554834191 @default.
• W3110753676 cites W2576657796 @default.
• W3110753676 cites W2603755876 @default.
• W3110753676 cites W2608366939 @default.
• W3110753676 cites W2610475210 @default.
• W3110753676 cites W2640839467 @default.
• W3110753676 cites W2737199903 @default.
• W3110753676 cites W2759519500 @default.
• W3110753676 cites W2766249541 @default.
• W3110753676 cites W2803165316 @default.
• W3110753676 cites W2903973776 @default.
• W3110753676 cites W2910103889 @default.
• W3110753676 cites W2911461474 @default.
• W3110753676 cites W2935872270 @default.
• W3110753676 cites W2971570023 @default.
• W3110753676 cites W3012343187 @default.
• W3110753676 doi "https://doi.org/10.1016/j.jep.2020.113699" @default.
• W3110753676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33340600" @default.
• W3110753676 hasPublicationYear "2021" @default.
• W3110753676 type Work @default.
• W3110753676 sameAs 3110753676 @default.
• W3110753676 citedByCount "23" @default.
• W3110753676 countsByYear W31107536762021 @default.
• W3110753676 countsByYear W31107536762022 @default.
• W3110753676 countsByYear W31107536762023 @default.
• W3110753676 crossrefType "journal-article" @default.
• W3110753676 hasAuthorship W3110753676A5030729208 @default.
• W3110753676 hasAuthorship W3110753676A5045863585 @default.
• W3110753676 hasAuthorship W3110753676A5058296735 @default.
• W3110753676 hasConcept C104317684 @default.
• W3110753676 hasConcept C118687296 @default.
• W3110753676 hasConcept C14225744 @default.
• W3110753676 hasConcept C151730666 @default.
• W3110753676 hasConcept C185592680 @default.
• W3110753676 hasConcept C2777637488 @default.
• W3110753676 hasConcept C2777916119 @default.
• W3110753676 hasConcept C2778004101 @default.
• W3110753676 hasConcept C2779343474 @default.
• W3110753676 hasConcept C2781401929 @default.
• W3110753676 hasConcept C2781427627 @default.
• W3110753676 hasConcept C501593827 @default.
• W3110753676 hasConcept C523546767 @default.
• W3110753676 hasConcept C54355233 @default.
• W3110753676 hasConcept C55493867 @default.
• W3110753676 hasConcept C556039675 @default.
• W3110753676 hasConcept C58123911 @default.
• W3110753676 hasConcept C60987743 @default.
• W3110753676 hasConcept C71924100 @default.
• W3110753676 hasConcept C86803240 @default.
• W3110753676 hasConcept C89423630 @default.
• W3110753676 hasConceptScore W3110753676C104317684 @default.
• W3110753676 hasConceptScore W3110753676C118687296 @default.
• W3110753676 hasConceptScore W3110753676C14225744 @default.
• W3110753676 hasConceptScore W3110753676C151730666 @default.
• W3110753676 hasConceptScore W3110753676C185592680 @default.
• W3110753676 hasConceptScore W3110753676C2777637488 @default.
• W3110753676 hasConceptScore W3110753676C2777916119 @default.
• W3110753676 hasConceptScore W3110753676C2778004101 @default.
• W3110753676 hasConceptScore W3110753676C2779343474 @default.
• W3110753676 hasConceptScore W3110753676C2781401929 @default.

• next