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• W3110778284 endingPage "17" @default.
• W3110778284 startingPage "1" @default.
• W3110778284 abstract "The spleen is a large secondary lymphoid organ located in the blood-stream, primarily functioning as a massive blood filter. It filtered effete red blood cells, antigen-antibody complexes, apoptotic bodies, damaged cells, among others. Spleen's myriad microanatomy reflects the diversity and complexity of its functions. As a specialized immune organ, the spleen immune system plays a significant role in innate and adaptive immunity. Specialized innate immune cells like B cells, natural killer (NK) cells, and macrophages populate locations within the spleen. Specifically, the spleen is a crucial organ for peripheral immune tolerance, complementing central immune tolerance. Spleen remains the only organ in the body capable of mounting an appropriate immune response to encapsulated bacteria. Spleen houses tolerogenic immune cells like CD8⁺ Treg cells, F4/80⁺ macrophages, CD68⁺F4/80⁺ red pulp macrophages, CD169⁺ metallophillic macrophages, CD8⁺CD205⁺ splenic dendritic cells (DCs), splenic CD8α⁺CD103⁺CD207⁺ DCs, CD43^+veCD19^hiCD5^+veIgM^hiIgD^lo B cells, and splenic NKT cells that express regulated on activation normal T cell expressed and secreted (RANTES/CCL5) chemokine. Splenocytes are extra-thymic autoimmune regulator gene (AIRE) expressing cells that regulate tissue-specific antigens' expression to confer peripheral immune tolerance. As such, the spleen provides the right site for counteracting autoimmunity. Splenectomy in both study animals and humans results in overwhelming infections with, especially encapsulated bacteria. The anterior chamber-associated immune deviation (ACAID) is closely related to the spleen that needs to be studied to improve transplant survival. The role of the spleen in anti-tumor immunity yields an inconclusive result. In-depth research is needed to find which cells or pathways are linked to favorable outcomes concerning cancer. Understanding the spleen's microanatomy and physiology will provide a framework for treating diseases, especially autoimmune diseases, cancer, infections, and transplantation." @default.
• W3110778284 created "2020-12-21" @default.
• W3110778284 creator A5040855145 @default.
• W3110778284 creator A5056623774 @default.
• W3110778284 creator A5058857394 @default.
• W3110778284 date "2021-01-01" @default.
• W3110778284 modified "2023-10-16" @default.
• W3110778284 title "Spleen in innate and adaptive immunity regulation" @default.
• W3110778284 cites W112407991 @default.
• W3110778284 cites W1444346221 @default.
• W3110778284 cites W1467581958 @default.
• W3110778284 cites W1508120038 @default.
• W3110778284 cites W1514468904 @default.
• W3110778284 cites W1522382197 @default.
• W3110778284 cites W1526209767 @default.
• W3110778284 cites W1536506913 @default.
• W3110778284 cites W1602231594 @default.
• W3110778284 cites W1624344496 @default.
• W3110778284 cites W1641628118 @default.
• W3110778284 cites W1828598189 @default.
• W3110778284 cites W1922792575 @default.
• W3110778284 cites W1968108602 @default.
• W3110778284 cites W1968960673 @default.
• W3110778284 cites W1969119554 @default.
• W3110778284 cites W1970370051 @default.
• W3110778284 cites W1972489295 @default.
• W3110778284 cites W1981160000 @default.
• W3110778284 cites W1986097563 @default.
• W3110778284 cites W2000865322 @default.
• W3110778284 cites W2005251163 @default.
• W3110778284 cites W2005350058 @default.
• W3110778284 cites W2007761469 @default.
• W3110778284 cites W2014090906 @default.
• W3110778284 cites W2022162385 @default.
• W3110778284 cites W2025291853 @default.
• W3110778284 cites W2029640926 @default.
• W3110778284 cites W2030758522 @default.
• W3110778284 cites W2030996837 @default.
• W3110778284 cites W2032057334 @default.
• W3110778284 cites W2032157551 @default.
• W3110778284 cites W2034402052 @default.
• W3110778284 cites W2035681212 @default.
• W3110778284 cites W2038694264 @default.
• W3110778284 cites W2042384977 @default.
• W3110778284 cites W2046801873 @default.
• W3110778284 cites W2050092675 @default.
• W3110778284 cites W2053485564 @default.
• W3110778284 cites W2054533099 @default.
• W3110778284 cites W2057470166 @default.
• W3110778284 cites W2061224018 @default.
• W3110778284 cites W2065338876 @default.
• W3110778284 cites W2068073223 @default.
• W3110778284 cites W2082896747 @default.
• W3110778284 cites W2088058388 @default.
• W3110778284 cites W2092366783 @default.
• W3110778284 cites W2093565968 @default.
• W3110778284 cites W2094635731 @default.
• W3110778284 cites W2096992222 @default.
• W3110778284 cites W2101957891 @default.
• W3110778284 cites W2105632712 @default.
• W3110778284 cites W2106100723 @default.
• W3110778284 cites W2107944244 @default.
• W3110778284 cites W2109192069 @default.
• W3110778284 cites W2110965052 @default.
• W3110778284 cites W2111415894 @default.
• W3110778284 cites W2112430000 @default.
• W3110778284 cites W2113702305 @default.
• W3110778284 cites W2114256642 @default.
• W3110778284 cites W2115359896 @default.
• W3110778284 cites W2127463671 @default.
• W3110778284 cites W2132478002 @default.
• W3110778284 cites W2136098797 @default.
• W3110778284 cites W2146566059 @default.
• W3110778284 cites W2158279077 @default.
• W3110778284 cites W2160400980 @default.
• W3110778284 cites W2162645937 @default.
• W3110778284 cites W2168850497 @default.
• W3110778284 cites W2179052305 @default.
• W3110778284 cites W2223338271 @default.
• W3110778284 cites W2403338780 @default.
• W3110778284 cites W2464084408 @default.
• W3110778284 cites W2471767420 @default.
• W3110778284 cites W2484310576 @default.
• W3110778284 cites W2566025746 @default.
• W3110778284 cites W2603093654 @default.
• W3110778284 cites W2605014235 @default.
• W3110778284 cites W2605748956 @default.
• W3110778284 cites W2635801861 @default.
• W3110778284 cites W2742344549 @default.
• W3110778284 cites W2766076678 @default.
• W3110778284 cites W2771059969 @default.
• W3110778284 cites W2771153486 @default.
• W3110778284 cites W2782884082 @default.
• W3110778284 cites W2785147419 @default.
• W3110778284 cites W2785227323 @default.
• W3110778284 cites W2785396374 @default.
• W3110778284 cites W2789530365 @default.
• W3110778284 cites W2791379020 @default.

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