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• W3110781765 endingPage "105103" @default.
• W3110781765 startingPage "105103" @default.
• W3110781765 abstract "Major depressive disorder (MDD) is the most common psychiatric disorder and responds for important psychosocial consequences. Stressful life events, especially early life stress (ELS), contribute to an increased probability to develop MDD, leading in particular to severe and chronic manifestation and unfavorable treatment outcome. The association between ELS and MDD seems to have biological bases, consisting in dysregulations occurring at different levels. The aim of this narrative review is to propose an overview of the literature ranging from genetic, epigenetic, expression and protein to neuroimaging correlates underlying this relationship. A search on Pubmed of studies assessing biological correlates of ELS in MDD development, focusing on human studies conducted in both peripheral and brain tissues, was performed. Evidence indicated that the hypothalamic-pituitary-adrenal (HPA) axis and the serotonergic, dopaminergic, neurotrophin and oxytocin systems might play a role in the mediation between ELS and MDD. The most consistent results were found for genetic and epigenetic studies and indicated a joint involvement of the systems mentioned. Expression studies are less numerous and point to an involvement of stress-related systems. Concerning protein studies, the main mediators are markers related to the inflammatory and immune systems. Neuroimaging studies aiming at evaluating brain alterations connecting ELS and MDD in relation to biomarkers indicated the hippocampus, the amygdala and the frontal cortex as important anatomical mediators. These findings can build the bases for future research and clinical interventions; indeed, the clarification of biological mechanisms mediating the relationship between ELS and MDD can lead to new and individualized preventive and therapeutic possibilities." @default.
• W3110781765 created "2020-12-21" @default.
• W3110781765 creator A5031084817 @default.
• W3110781765 creator A5032329666 @default.
• W3110781765 creator A5058227972 @default.
• W3110781765 creator A5069018253 @default.
• W3110781765 creator A5088257381 @default.
• W3110781765 date "2021-03-01" @default.
• W3110781765 modified "2023-10-16" @default.
• W3110781765 title "Biological correlates of early life stressful events in major depressive disorder" @default.
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