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• W3110791569 endingPage "641" @default.
• W3110791569 startingPage "617" @default.
• W3110791569 abstract "Cardiovascular diseases (CVDs) are the major cause of death all over the world, being responsible for 7.4 million deaths in a year. In the past two decades, advances in biomaterials, stem cell biology, and engineering have allowed the generation of tissue constructs that can imitate the complex structure of the heart and, upon transplantation into animal models, improved the cardiac function. Consequently, stem cell-based cardiac tissue engineering (CTE) has emerged as a potential therapeutic strategy for the treatment of CVDs. The choice of appropriate biomaterials that can provide differentiating and paracrine milieu to mimic the extracellular matrix (ECM) is the key to the proper functioning of cardiac tissue construct. Plant- or animal-derived natural polymers such as alginate, chitosan, collagen, fibrin, gelatin, and glycosaminoglycan are biocompatible and facilitate cell adhesion, proliferation, and differentiation for development of cardiac tissue constructs. On the other hand, natural biomaterials such as collagen, fibronectin, laminin, nephronectin, etc. are often used to biofunctionalize the synthetic biomaterials-derived scaffolds to enhance cell adhesion and cell-to-cell communication. This book chapter discusses various approaches for CTE and the role of different natural biomaterials and their importance in the biofunctionalization of synthetic biomaterials for developing cardiac tissue constructs." @default.
• W3110791569 created "2020-12-21" @default.
• W3110791569 creator A5034243631 @default.
• W3110791569 creator A5075476806 @default.
• W3110791569 date "2020-12-15" @default.
• W3110791569 modified "2023-10-17" @default.
• W3110791569 title "Cardiac Tissue Engineering: A Role for Natural Biomaterials" @default.
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