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- W3110828527 endingPage "9608" @default.
- W3110828527 startingPage "9608" @default.
- W3110828527 abstract "The strong association with the Major Histocompatibility Complex (MHC) class I genes represents a shared trait for a group of autoimmune/autoinflammatory disorders having in common immunopathogenetic basis as well as clinical features. Accordingly, the main risk factors for Ankylosing Spondylitis (AS), prototype of the Spondyloarthropathies (SpA), the Behçet’s disease (BD), the Psoriasis (Ps) and the Birdshot Chorioretinopathy (BSCR) are HLA-B*27, HLA-B*51, HLA-C*06:02 and HLA-A*29:02, respectively. Despite the strength of the association, the HLA pathogenetic role in these diseases is far from being thoroughly understood. Furthermore, Genome-Wide Association Studies (GWAS) have highlighted other important susceptibility factors such as Endoplasmic Reticulum Aminopeptidase (ERAP) 1 and, less frequently, ERAP2 that refine the peptidome presented by HLA class I molecules to CD8+ T cells. Mass spectrometry analysis provided considerable knowledge of HLA-B*27, HLA-B*51, HLA-C*06:02 and HLA-A*29:02 immunopeptidome. However, the combined effect of several ERAP1 and ERAP2 allelic variants could generate an altered pool of peptides accounting for the “mis-immunopeptidome” that ranges from suboptimal to pathogenetic/harmful peptides able to induce non-canonical or autoreactive CD8+ T responses, activation of NK cells and/or garbling the classical functions of the HLA class I molecules. This review will focus on this class of epitopes as possible elicitors of atypical/harmful immune responses which can contribute to the pathogenesis of chronic inflammatory diseases." @default.
- W3110828527 created "2020-12-21" @default.
- W3110828527 creator A5018739140 @default.
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- W3110828527 creator A5053824260 @default.
- W3110828527 creator A5071444068 @default.
- W3110828527 creator A5083405572 @default.
- W3110828527 date "2020-12-17" @default.
- W3110828527 modified "2023-10-17" @default.
- W3110828527 title "The Impact of the ‘Mis-Peptidome’ on HLA Class I-Mediated Diseases: Contribution of ERAP1 and ERAP2 and Effects on the Immune Response" @default.
- W3110828527 cites W1490573271 @default.
- W3110828527 cites W1513304325 @default.
- W3110828527 cites W1556289374 @default.
- W3110828527 cites W159683066 @default.
- W3110828527 cites W1963742202 @default.
- W3110828527 cites W1964497881 @default.
- W3110828527 cites W1970766115 @default.
- W3110828527 cites W1973449326 @default.
- W3110828527 cites W1973515440 @default.
- W3110828527 cites W1975810460 @default.
- W3110828527 cites W1984819081 @default.
- W3110828527 cites W1986052810 @default.
- W3110828527 cites W1995243099 @default.
- W3110828527 cites W2004633497 @default.
- W3110828527 cites W2005576094 @default.
- W3110828527 cites W2018361021 @default.
- W3110828527 cites W2019855029 @default.
- W3110828527 cites W2022175407 @default.
- W3110828527 cites W2026640285 @default.
- W3110828527 cites W2027195037 @default.
- W3110828527 cites W2034287733 @default.
- W3110828527 cites W2038226782 @default.
- W3110828527 cites W2038525279 @default.
- W3110828527 cites W2043577610 @default.
- W3110828527 cites W2048510007 @default.
- W3110828527 cites W2051761882 @default.
- W3110828527 cites W2052564277 @default.
- W3110828527 cites W2056295780 @default.
- W3110828527 cites W2068057642 @default.
- W3110828527 cites W2074807009 @default.
- W3110828527 cites W2088355124 @default.
- W3110828527 cites W2090443272 @default.
- W3110828527 cites W2092867579 @default.
- W3110828527 cites W2093217973 @default.
- W3110828527 cites W2093308972 @default.
- W3110828527 cites W2093881459 @default.
- W3110828527 cites W2095712743 @default.
- W3110828527 cites W2097602001 @default.
- W3110828527 cites W2102889851 @default.
- W3110828527 cites W2105842551 @default.
- W3110828527 cites W2107730744 @default.
- W3110828527 cites W2109782136 @default.
- W3110828527 cites W2126898871 @default.
- W3110828527 cites W2135709828 @default.
- W3110828527 cites W2137599490 @default.
- W3110828527 cites W2141264604 @default.
- W3110828527 cites W2145958269 @default.
- W3110828527 cites W2148529568 @default.
- W3110828527 cites W2154988908 @default.
- W3110828527 cites W2156459362 @default.
- W3110828527 cites W2160198934 @default.
- W3110828527 cites W2161221618 @default.
- W3110828527 cites W2161467556 @default.
- W3110828527 cites W2162322548 @default.
- W3110828527 cites W2167418901 @default.
- W3110828527 cites W2171043308 @default.
- W3110828527 cites W2181499040 @default.
- W3110828527 cites W2210089725 @default.
- W3110828527 cites W2238339241 @default.
- W3110828527 cites W2242847088 @default.
- W3110828527 cites W2275572529 @default.
- W3110828527 cites W2312980219 @default.
- W3110828527 cites W2338072779 @default.
- W3110828527 cites W2343291160 @default.
- W3110828527 cites W2410905159 @default.
- W3110828527 cites W2466074519 @default.
- W3110828527 cites W2506275367 @default.
- W3110828527 cites W2561759163 @default.
- W3110828527 cites W2586154810 @default.
- W3110828527 cites W2589139221 @default.
- W3110828527 cites W2609628591 @default.
- W3110828527 cites W2612782028 @default.
- W3110828527 cites W2739935200 @default.
- W3110828527 cites W2748858560 @default.
- W3110828527 cites W2754504899 @default.
- W3110828527 cites W2754733375 @default.
- W3110828527 cites W2767292105 @default.
- W3110828527 cites W2791022192 @default.
- W3110828527 cites W2800812572 @default.
- W3110828527 cites W2803336050 @default.
- W3110828527 cites W2810881461 @default.
- W3110828527 cites W2883199250 @default.
- W3110828527 cites W2888316617 @default.
- W3110828527 cites W2888545638 @default.
- W3110828527 cites W2899507676 @default.
- W3110828527 cites W2905494341 @default.