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• W3110873485 abstract "Abstract The rooting of the SARS-CoV-2 phylogeny is important for understanding the origin and early spread of the virus. Previously published phylogenies have used different rootings that do not always provide consistent results. We investigate several different strategies for rooting the SARS-CoV-2 tree and provide measures of statistical uncertainty for all methods. We show that methods based on the molecular clock tend to place the root in the B clade, whereas methods based on outgroup rooting tend to place the root in the A clade. The results from the two approaches are statistically incompatible, possibly as a consequence of deviations from a molecular clock or excess back-mutations. We also show that none of the methods provide strong statistical support for the placement of the root in any particular edge of the tree. These results suggest that phylogenetic evidence alone is unlikely to identify the origin of the SARS-CoV-2 virus and we caution against strong inferences regarding the early spread of the virus based solely on such evidence." @default.
• W3110873485 created "2020-12-21" @default.
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• W3110873485 date "2020-12-09" @default.
• W3110873485 modified "2023-09-30" @default.
• W3110873485 title "Assessing Uncertainty in the Rooting of the SARS-CoV-2 Phylogeny" @default.
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• W3110873485 doi "https://doi.org/10.1093/molbev/msaa316" @default.
• W3110873485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7798932" @default.
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• W3110873485 hasPublicationYear "2020" @default.
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