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- W3110971344 abstract "Abstract While constitutive CCCTC-binding factor (CTCF)–binding sites are needed to maintain relatively invariant chromatin structures, such as topologically associating domains, the precise roles of CTCF to control cell-type–specific transcriptional regulation remain poorly explored. We examined CTCF occupancy in different types of primary blood cells derived from the same donor to elucidate a new role for CTCF in gene regulation during blood cell development. We identified dynamic, cell-type–specific binding sites for CTCF that colocalize with lineage-specific transcription factors. These dynamic sites are enriched for single-nucleotide polymorphisms that are associated with blood cell traits in different linages, and they coincide with the key regulatory elements governing hematopoiesis. CRISPR-Cas9–based perturbation experiments demonstrated that these dynamic CTCF-binding sites play a critical role in red blood cell development. Furthermore, precise deletion of CTCF-binding motifs in dynamic sites abolished interactions of erythroid genes, such as RBM38, with their associated enhancers and led to abnormal erythropoiesis. These results suggest a novel, cell-type–specific function for CTCF in which it may serve to facilitate interaction of distal regulatory emblements with target promoters. Our study of the dynamic, cell-type–specific binding and function of CTCF provides new insights into transcriptional regulation during hematopoiesis." @default.
- W3110971344 created "2020-12-21" @default.
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- W3110971344 date "2021-03-11" @default.
- W3110971344 modified "2023-10-16" @default.
- W3110971344 title "Dynamic CTCF binding directly mediates interactions among <i>cis</i>-regulatory elements essential for hematopoiesis" @default.
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- W3110971344 doi "https://doi.org/10.1182/blood.2020005780" @default.
- W3110971344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7955410" @default.
- W3110971344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33512425" @default.
- W3110971344 hasPublicationYear "2021" @default.
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