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- W3110989881 abstract "Abstract Oxygen-dependent quenching of delayed fluorescence of protoporphyrin IX (PpIX) is a method for measuring oxygen at the mitochondrial level in cells and tissues. The technique uses the optical properties of 5-aminolevulinic acid–enhanced mitochondrial PpIX to measure mitochondrial oxygen tension (mitoPO2). Administration of aminolevulinic acid induces measurable levels of PpIX in the mitochondria where PpIX acts as an oxygen-sensitive dye. PpIX emits a red delayed fluorescence after excitation with a pulse of green light. The lifetime of the delayed fluorescence is inversely related to mitoPO2. MitoPO2 can be calculated from the lifetime according to the Stern–Volmer equation. Dynamic mitoPO2 measurements during local cessation of oxygen supply allow for assessing mitochondrial oxygen consumption (mitoVO2) as a measure for cellular respiration in vivo. It is now possible to measure mitoPO2 and mitoVO2 in patients at the bedside using the COMET (cellular oxygen metabolism) measuring system. The COMET is a CE-marked device for measuring mitochondrial oxygenation in human skin and is currently being tried and tested in several clinical trials. In this chapter, we will discuss the background of the technique and the rationale to measure tissue oxygenation at the mitochondrial level. We also provide examples of COMET measurements in the perioperative setting." @default.
- W3110989881 created "2020-12-21" @default.
- W3110989881 creator A5047814442 @default.
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- W3110989881 date "2021-01-01" @default.
- W3110989881 modified "2023-09-23" @default.
- W3110989881 title "Monitoring mitochondrial oxygenation in clinical environment" @default.
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- W3110989881 doi "https://doi.org/10.1016/b978-0-12-819621-2.00009-7" @default.
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