FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110996865> ?p ?o ?g. }

• W3110996865 endingPage "C414" @default.
• W3110996865 startingPage "C392" @default.
• W3110996865 abstract "A primary function of the H+-ATPase (or V-ATPase) is to create an electrochemical proton gradient across eukaryotic cell membranes, which energizes fundamental cellular processes. Its activity allows for the acidification of intracellular vesicles and organelles, which is necessary for many essential cell biological events to occur. In addition, many specialized cell types in various organ systems such as the kidney, bone, male reproductive tract, inner ear, olfactory mucosa, and more, use plasma membrane V-ATPases to perform specific activities that depend on extracellular acidification. It is, however, increasingly apparent that V-ATPases are central players in many normal and pathophysiological processes that directly influence human health in many different and sometimes unexpected ways. These include cancer, neurodegenerative diseases, diabetes, and sensory perception, as well as energy and nutrient-sensing functions within cells. This review first covers the well-established role of the V-ATPase as a transmembrane proton pump in the plasma membrane and intracellular vesicles and outlines factors contributing to its physiological regulation in different cell types. This is followed by a discussion of the more recently emerging unconventional roles for the V-ATPase, such as its role as a protein interaction hub involved in cell signaling, and the (patho)physiological implications of these interactions. Finally, the central importance of endosomal acidification and V-ATPase activity on viral infection will be discussed in the context of the current COVID-19 pandemic." @default.
• W3110996865 created "2020-12-21" @default.
• W3110996865 creator A5047220293 @default.
• W3110996865 creator A5050588407 @default.
• W3110996865 creator A5087672907 @default.
• W3110996865 date "2021-03-01" @default.
• W3110996865 modified "2023-10-16" @default.
• W3110996865 title "The H⁺-ATPase (V-ATPase): from proton pump to signaling complex in health and disease" @default.
• W3110996865 cites W119105153 @default.
• W3110996865 cites W119572665 @default.
• W3110996865 cites W1504256022 @default.
• W3110996865 cites W1507712770 @default.
• W3110996865 cites W1541488575 @default.
• W3110996865 cites W1550693054 @default.
• W3110996865 cites W1578236466 @default.
• W3110996865 cites W1578740436 @default.
• W3110996865 cites W1581489141 @default.
• W3110996865 cites W1583074038 @default.
• W3110996865 cites W1596299677 @default.
• W3110996865 cites W1803199265 @default.
• W3110996865 cites W1837937318 @default.
• W3110996865 cites W1878909517 @default.
• W3110996865 cites W1903191587 @default.
• W3110996865 cites W1906008749 @default.
• W3110996865 cites W1927156752 @default.
• W3110996865 cites W1963903089 @default.
• W3110996865 cites W1964675692 @default.
• W3110996865 cites W1966025469 @default.
• W3110996865 cites W1966179542 @default.
• W3110996865 cites W1968809832 @default.
• W3110996865 cites W1971394915 @default.
• W3110996865 cites W1973596053 @default.
• W3110996865 cites W1975155714 @default.
• W3110996865 cites W1975326873 @default.
• W3110996865 cites W1976896999 @default.
• W3110996865 cites W1982242384 @default.
• W3110996865 cites W1983837942 @default.
• W3110996865 cites W1985908916 @default.
• W3110996865 cites W1986001368 @default.
• W3110996865 cites W1986204805 @default.
• W3110996865 cites W1988786406 @default.
• W3110996865 cites W1990534862 @default.
• W3110996865 cites W1990985479 @default.
• W3110996865 cites W1993250284 @default.
• W3110996865 cites W1993916597 @default.
• W3110996865 cites W1994633155 @default.
• W3110996865 cites W1995004385 @default.
• W3110996865 cites W1997026714 @default.
• W3110996865 cites W1997460720 @default.
• W3110996865 cites W1997657755 @default.
• W3110996865 cites W1998641605 @default.
• W3110996865 cites W2000678720 @default.
• W3110996865 cites W2004501853 @default.
• W3110996865 cites W2004960318 @default.
• W3110996865 cites W2005496979 @default.
• W3110996865 cites W2006513791 @default.
• W3110996865 cites W2008548724 @default.
• W3110996865 cites W2008847964 @default.
• W3110996865 cites W2010332106 @default.
• W3110996865 cites W2010506265 @default.
• W3110996865 cites W2011867368 @default.
• W3110996865 cites W2012744190 @default.
• W3110996865 cites W2013876235 @default.
• W3110996865 cites W2016444704 @default.
• W3110996865 cites W2016913573 @default.
• W3110996865 cites W2018043075 @default.
• W3110996865 cites W2020300656 @default.
• W3110996865 cites W2022278464 @default.
• W3110996865 cites W2022879707 @default.
• W3110996865 cites W2023720990 @default.
• W3110996865 cites W2026389758 @default.
• W3110996865 cites W2027484375 @default.
• W3110996865 cites W2027718679 @default.
• W3110996865 cites W2028638550 @default.
• W3110996865 cites W2029272680 @default.
• W3110996865 cites W2030677245 @default.
• W3110996865 cites W2032184616 @default.
• W3110996865 cites W2035353547 @default.
• W3110996865 cites W2036135042 @default.
• W3110996865 cites W2036762444 @default.
• W3110996865 cites W2038360620 @default.
• W3110996865 cites W2039037981 @default.
• W3110996865 cites W2040367894 @default.
• W3110996865 cites W2042311423 @default.
• W3110996865 cites W2043584980 @default.
• W3110996865 cites W2043664125 @default.
• W3110996865 cites W2044052559 @default.
• W3110996865 cites W2044627978 @default.
• W3110996865 cites W2045165927 @default.
• W3110996865 cites W2046108411 @default.
• W3110996865 cites W2050253418 @default.
• W3110996865 cites W2051120450 @default.
• W3110996865 cites W2051466507 @default.
• W3110996865 cites W2054462619 @default.
• W3110996865 cites W2055075191 @default.
• W3110996865 cites W2055945283 @default.
• W3110996865 cites W2056138506 @default.
• W3110996865 cites W2056408336 @default.

• next