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- W3111007684 abstract "KMT2 (histone-lysine N-methyltransferase subclass 2) complexes methylate lysine 4 on the histone H3 tail at gene promoters and gene enhancers and, thus, control the process of gene transcription. These complexes not only play an essential role in normal development but have also been described as involved in the aberrant growth of tissues. KMT2 mutations resulting from the rearrangements of the KMT2A (MLL1) gene at 11q23 are associated with pediatric mixed-lineage leukemias, and recent studies demonstrate that KMT2 genes are frequently mutated in many types of human cancers. Moreover, other components of the KMT2 complexes have been reported to contribute to oncogenesis. This review summarizes the recent advances in our knowledge of the role of KMT2 complexes in cell transformation. In addition, it discusses the therapeutic targeting of different components of the KMT2 complexes." @default.
- W3111007684 created "2020-12-21" @default.
- W3111007684 creator A5006040821 @default.
- W3111007684 creator A5033026135 @default.
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- W3111007684 date "2020-12-08" @default.
- W3111007684 modified "2023-10-16" @default.
- W3111007684 title "Aberrant Activity of Histone–Lysine N-Methyltransferase 2 (KMT2) Complexes in Oncogenesis" @default.
- W3111007684 cites W1415589110 @default.
- W3111007684 cites W1432929478 @default.
- W3111007684 cites W1509538618 @default.
- W3111007684 cites W1528147088 @default.
- W3111007684 cites W1548068969 @default.
- W3111007684 cites W1555883714 @default.
- W3111007684 cites W1573937463 @default.
- W3111007684 cites W1575147957 @default.
- W3111007684 cites W1583158213 @default.
- W3111007684 cites W1768917741 @default.
- W3111007684 cites W1792088282 @default.
- W3111007684 cites W1824828567 @default.
- W3111007684 cites W1848866248 @default.
- W3111007684 cites W1946340684 @default.
- W3111007684 cites W1948730391 @default.
- W3111007684 cites W1965108615 @default.
- W3111007684 cites W1965270682 @default.
- W3111007684 cites W1965343063 @default.
- W3111007684 cites W1967381498 @default.
- W3111007684 cites W1971015258 @default.
- W3111007684 cites W1975511102 @default.
- W3111007684 cites W1975554088 @default.
- W3111007684 cites W1976033223 @default.
- W3111007684 cites W1979316039 @default.
- W3111007684 cites W1981069958 @default.
- W3111007684 cites W1981259598 @default.
- W3111007684 cites W1981493445 @default.
- W3111007684 cites W1982315838 @default.
- W3111007684 cites W1982640053 @default.
- W3111007684 cites W1982716235 @default.
- W3111007684 cites W1985171686 @default.
- W3111007684 cites W1985515480 @default.
- W3111007684 cites W1990174038 @default.
- W3111007684 cites W1990739246 @default.
- W3111007684 cites W1992048312 @default.
- W3111007684 cites W1992662525 @default.
- W3111007684 cites W1992964343 @default.
- W3111007684 cites W1993648003 @default.
- W3111007684 cites W1996224069 @default.
- W3111007684 cites W1996315419 @default.
- W3111007684 cites W1996600754 @default.
- W3111007684 cites W1998871958 @default.
- W3111007684 cites W2000474359 @default.
- W3111007684 cites W2001311465 @default.
- W3111007684 cites W2003053220 @default.
- W3111007684 cites W2003292748 @default.
- W3111007684 cites W2004919210 @default.
- W3111007684 cites W2005829971 @default.
- W3111007684 cites W2005909602 @default.
- W3111007684 cites W2006463715 @default.
- W3111007684 cites W2006593022 @default.
- W3111007684 cites W2007342561 @default.
- W3111007684 cites W2007525719 @default.
- W3111007684 cites W2008902252 @default.
- W3111007684 cites W2011152373 @default.
- W3111007684 cites W2012606436 @default.
- W3111007684 cites W2013585481 @default.
- W3111007684 cites W2015477868 @default.
- W3111007684 cites W2016058704 @default.
- W3111007684 cites W2016148607 @default.
- W3111007684 cites W2017694656 @default.
- W3111007684 cites W2020095066 @default.
- W3111007684 cites W2022495797 @default.
- W3111007684 cites W2024584416 @default.
- W3111007684 cites W2025570007 @default.
- W3111007684 cites W2026576443 @default.
- W3111007684 cites W2027010175 @default.
- W3111007684 cites W2027216468 @default.
- W3111007684 cites W2027556551 @default.
- W3111007684 cites W2031373255 @default.
- W3111007684 cites W2031824350 @default.
- W3111007684 cites W2032295900 @default.
- W3111007684 cites W2032456223 @default.
- W3111007684 cites W2034269086 @default.
- W3111007684 cites W2036619779 @default.
- W3111007684 cites W2036931724 @default.
- W3111007684 cites W2036986058 @default.
- W3111007684 cites W2037374227 @default.
- W3111007684 cites W2037856618 @default.
- W3111007684 cites W2038235796 @default.
- W3111007684 cites W2039916661 @default.
- W3111007684 cites W2041440766 @default.
- W3111007684 cites W2042871287 @default.
- W3111007684 cites W2044386584 @default.
- W3111007684 cites W2044413378 @default.
- W3111007684 cites W2046766666 @default.
- W3111007684 cites W2048613921 @default.
- W3111007684 cites W2051025382 @default.
- W3111007684 cites W2051888282 @default.
- W3111007684 cites W2052744416 @default.