Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111020808> ?p ?o ?g. }
- W3111020808 endingPage "121.e5" @default.
- W3111020808 startingPage "109" @default.
- W3111020808 abstract "Tumors with defective mismatch repair (dMMR) are responsive to immunotherapy because of dMMR-induced neoantigens and activation of the cGAS-STING pathway. While neoantigens result from the hypermutable nature of dMMR, it is unknown how dMMR activates the cGAS-STING pathway. We show here that loss of the MutLα subunit MLH1, whose defect is responsible for ~50% of dMMR cancers, results in loss of MutLα-specific regulation of exonuclease 1 (Exo1) during DNA repair. This leads to unrestrained DNA excision by Exo1, which causes increased single-strand DNA formation, RPA exhaustion, DNA breaks, and aberrant DNA repair intermediates. Ultimately, this generates chromosomal abnormalities and the release of nuclear DNA into the cytoplasm, activating the cGAS-STING pathway. In this study, we discovered a hitherto unknown MMR mechanism that modulates genome stability and has implications for cancer therapy." @default.
- W3111020808 created "2020-12-21" @default.
- W3111020808 creator A5000591490 @default.
- W3111020808 creator A5018203024 @default.
- W3111020808 creator A5023086146 @default.
- W3111020808 creator A5026551920 @default.
- W3111020808 creator A5034512017 @default.
- W3111020808 creator A5039519985 @default.
- W3111020808 creator A5064030220 @default.
- W3111020808 creator A5065356075 @default.
- W3111020808 creator A5071912533 @default.
- W3111020808 creator A5074230402 @default.
- W3111020808 creator A5076149826 @default.
- W3111020808 creator A5076375239 @default.
- W3111020808 creator A5076809584 @default.
- W3111020808 creator A5079900226 @default.
- W3111020808 creator A5081012778 @default.
- W3111020808 creator A5083659054 @default.
- W3111020808 creator A5091408513 @default.
- W3111020808 date "2021-01-01" @default.
- W3111020808 modified "2023-10-14" @default.
- W3111020808 title "MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway" @default.
- W3111020808 cites W1931797416 @default.
- W3111020808 cites W1940241680 @default.
- W3111020808 cites W1963774361 @default.
- W3111020808 cites W1973260880 @default.
- W3111020808 cites W1975152594 @default.
- W3111020808 cites W1984895636 @default.
- W3111020808 cites W2004448876 @default.
- W3111020808 cites W2010898393 @default.
- W3111020808 cites W2019394964 @default.
- W3111020808 cites W2031211461 @default.
- W3111020808 cites W2031226720 @default.
- W3111020808 cites W2035129204 @default.
- W3111020808 cites W2037095827 @default.
- W3111020808 cites W2040681936 @default.
- W3111020808 cites W2041656651 @default.
- W3111020808 cites W2050164609 @default.
- W3111020808 cites W2052522374 @default.
- W3111020808 cites W2063847889 @default.
- W3111020808 cites W2067818712 @default.
- W3111020808 cites W2084797613 @default.
- W3111020808 cites W2096731080 @default.
- W3111020808 cites W2101231990 @default.
- W3111020808 cites W2104128454 @default.
- W3111020808 cites W2110912468 @default.
- W3111020808 cites W2119005391 @default.
- W3111020808 cites W2125792957 @default.
- W3111020808 cites W2126547130 @default.
- W3111020808 cites W2138076097 @default.
- W3111020808 cites W2140384792 @default.
- W3111020808 cites W2141798197 @default.
- W3111020808 cites W2158602985 @default.
- W3111020808 cites W2163377650 @default.
- W3111020808 cites W2181192066 @default.
- W3111020808 cites W2403685725 @default.
- W3111020808 cites W2464252485 @default.
- W3111020808 cites W2557336488 @default.
- W3111020808 cites W2580868078 @default.
- W3111020808 cites W2588778011 @default.
- W3111020808 cites W2622499649 @default.
- W3111020808 cites W2733154631 @default.
- W3111020808 cites W2738136165 @default.
- W3111020808 cites W2767524017 @default.
- W3111020808 cites W2795875233 @default.
- W3111020808 cites W2803857309 @default.
- W3111020808 cites W2884397450 @default.
- W3111020808 cites W2891901428 @default.
- W3111020808 cites W2897815318 @default.
- W3111020808 cites W2919692138 @default.
- W3111020808 cites W2921875691 @default.
- W3111020808 cites W2943500419 @default.
- W3111020808 cites W2946550609 @default.
- W3111020808 cites W2969094590 @default.
- W3111020808 cites W2971878785 @default.
- W3111020808 cites W3000527497 @default.
- W3111020808 cites W3006567221 @default.
- W3111020808 doi "https://doi.org/10.1016/j.ccell.2020.11.004" @default.
- W3111020808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33338427" @default.
- W3111020808 hasPublicationYear "2021" @default.
- W3111020808 type Work @default.
- W3111020808 sameAs 3111020808 @default.
- W3111020808 citedByCount "92" @default.
- W3111020808 countsByYear W31110208082021 @default.
- W3111020808 countsByYear W31110208082022 @default.
- W3111020808 countsByYear W31110208082023 @default.
- W3111020808 crossrefType "journal-article" @default.
- W3111020808 hasAuthorship W3111020808A5000591490 @default.
- W3111020808 hasAuthorship W3111020808A5018203024 @default.
- W3111020808 hasAuthorship W3111020808A5023086146 @default.
- W3111020808 hasAuthorship W3111020808A5026551920 @default.
- W3111020808 hasAuthorship W3111020808A5034512017 @default.
- W3111020808 hasAuthorship W3111020808A5039519985 @default.
- W3111020808 hasAuthorship W3111020808A5064030220 @default.
- W3111020808 hasAuthorship W3111020808A5065356075 @default.
- W3111020808 hasAuthorship W3111020808A5071912533 @default.
- W3111020808 hasAuthorship W3111020808A5074230402 @default.
- W3111020808 hasAuthorship W3111020808A5076149826 @default.