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- W3111034899 abstract "<p><a>Boronic acids have attracted the attention of synthetic and medicinal chemists due to boron’s ability to modulate enzyme function. </a>Recently, we demonstrated that boron-containing amphoteric building blocks facilitate the discovery of bioactive aminoboronic acids. Herein, we have augmented this capability with a <i>de novo</i> library design and virtural screening platform modified for covalent ligands. This technique has allowed us to rapidly design and identify a series of α-aminoboronic acids as the first inhibitors of human ClpXP, which is responsible for the degradation of misfolded proteins.</p>" @default.
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- W3111034899 date "2018-12-03" @default.
- W3111034899 modified "2023-09-23" @default.
- W3111034899 title "Design of Boron-Based Peptidomimetics Leads to Potent Inhibitors of Human ClpP and ClpXP" @default.
- W3111034899 doi "https://doi.org/10.26434/chemrxiv.7408565.v1" @default.
- W3111034899 hasPublicationYear "2018" @default.
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