FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111036614> ?p ?o ?g. }

• W3111036614 endingPage "760" @default.
• W3111036614 startingPage "746" @default.
• W3111036614 abstract "Major depression is a prevalent illness that increases the risk of several neurological conditions. These include stroke, cardiovascular disease, and dementia including Alzheimer's disease. In this review we ask whether certain types of depression and associated loneliness may be a harbinger of cognitive decline and possibly even dementia. We propose that chronic stress and inflammation combine to compromise vascular and brain function. The resulting increases in proinflammatory cytokines and microglial activation drive brain pathology leading to depression and mild cognitive impairment, which may progress to dementia. We present evidence that by treating the inflammatory changes, depression can be reversed in many cases. Importantly, there is evidence that anti-inflammatory and antidepressant treatments may reduce or prevent dementia in people with depression. Thus, we propose a model in which chronic stress and inflammation combine to increase brain permeability and cytokine production. This leads to microglial activation, white matter damage, neuronal and glial cell loss. This is first manifest as depression and mild cognitive impairment, but can eventually evolve into dementia. Further research may identify clinical subgroups with inflammatory depression at risk for dementia. It would then be possible to address in clinical trials whether effective treatment of the depression can delay the onset of dementia." @default.
• W3111036614 created "2020-12-21" @default.
• W3111036614 creator A5002795098 @default.
• W3111036614 creator A5051436662 @default.
• W3111036614 creator A5060205460 @default.
• W3111036614 date "2020-12-05" @default.
• W3111036614 modified "2023-10-11" @default.
• W3111036614 title "Depression, dementia and immune dysregulation" @default.
• W3111036614 cites W1482765914 @default.
• W3111036614 cites W1551347368 @default.
• W3111036614 cites W1558869300 @default.
• W3111036614 cites W1570428653 @default.
• W3111036614 cites W1588685142 @default.
• W3111036614 cites W17212509 @default.
• W3111036614 cites W1758604915 @default.
• W3111036614 cites W1934145944 @default.
• W3111036614 cites W1955944566 @default.
• W3111036614 cites W1962010571 @default.
• W3111036614 cites W1968484436 @default.
• W3111036614 cites W1968764187 @default.
• W3111036614 cites W1977585036 @default.
• W3111036614 cites W1978830885 @default.
• W3111036614 cites W1982108488 @default.
• W3111036614 cites W1984202178 @default.
• W3111036614 cites W1984760175 @default.
• W3111036614 cites W1985438873 @default.
• W3111036614 cites W1987727508 @default.
• W3111036614 cites W1989257393 @default.
• W3111036614 cites W1989369404 @default.
• W3111036614 cites W1989580462 @default.
• W3111036614 cites W1990487655 @default.
• W3111036614 cites W1992600058 @default.
• W3111036614 cites W1994257697 @default.
• W3111036614 cites W1994367842 @default.
• W3111036614 cites W1996024251 @default.
• W3111036614 cites W1997086296 @default.
• W3111036614 cites W1999709108 @default.
• W3111036614 cites W2003742995 @default.
• W3111036614 cites W2003982930 @default.
• W3111036614 cites W2004068229 @default.
• W3111036614 cites W2006940628 @default.
• W3111036614 cites W2014060223 @default.
• W3111036614 cites W2014398064 @default.
• W3111036614 cites W2014554123 @default.
• W3111036614 cites W2015135718 @default.
• W3111036614 cites W2016575029 @default.
• W3111036614 cites W2016606472 @default.
• W3111036614 cites W2017387370 @default.
• W3111036614 cites W2017495857 @default.
• W3111036614 cites W2027467386 @default.
• W3111036614 cites W2033028677 @default.
• W3111036614 cites W2033811826 @default.
• W3111036614 cites W2034275438 @default.
• W3111036614 cites W2034868284 @default.
• W3111036614 cites W2036167046 @default.
• W3111036614 cites W2039047987 @default.
• W3111036614 cites W2040046096 @default.
• W3111036614 cites W2040472175 @default.
• W3111036614 cites W2042799870 @default.
• W3111036614 cites W2043943546 @default.
• W3111036614 cites W2044404835 @default.
• W3111036614 cites W2044730465 @default.
• W3111036614 cites W2049395285 @default.
• W3111036614 cites W2050508296 @default.
• W3111036614 cites W2050961629 @default.
• W3111036614 cites W2052445727 @default.
• W3111036614 cites W2053239117 @default.
• W3111036614 cites W2053607004 @default.
• W3111036614 cites W2054219549 @default.
• W3111036614 cites W2055527753 @default.
• W3111036614 cites W2059150405 @default.
• W3111036614 cites W2059918917 @default.
• W3111036614 cites W2061360383 @default.
• W3111036614 cites W2063047220 @default.
• W3111036614 cites W2066595212 @default.
• W3111036614 cites W2066870378 @default.
• W3111036614 cites W2068747215 @default.
• W3111036614 cites W2070757879 @default.
• W3111036614 cites W2070949918 @default.
• W3111036614 cites W2075368428 @default.
• W3111036614 cites W2083739539 @default.
• W3111036614 cites W2086398583 @default.
• W3111036614 cites W2086697336 @default.
• W3111036614 cites W2087973865 @default.
• W3111036614 cites W2089535608 @default.
• W3111036614 cites W2091259554 @default.
• W3111036614 cites W2093484024 @default.
• W3111036614 cites W2094761688 @default.
• W3111036614 cites W2097594692 @default.
• W3111036614 cites W2098345971 @default.
• W3111036614 cites W2098731039 @default.
• W3111036614 cites W2099516158 @default.
• W3111036614 cites W2102197505 @default.
• W3111036614 cites W2104205224 @default.
• W3111036614 cites W2106159603 @default.
• W3111036614 cites W2109172889 @default.
• W3111036614 cites W2114149118 @default.
• W3111036614 cites W2120032880 @default.

• next