FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111111518> ?p ?o ?g. }

• W3111111518 endingPage "e23840" @default.
• W3111111518 startingPage "e23840" @default.
• W3111111518 abstract "Tumor-associated macrophages (TAMs) play a crucial role in the immune response to many malignancies, but the signaling pathways by which the glioma microenvironment cross-talk with TAMs are poorly understood. The aim of this study was to uncover the potential signaling pathways of the regulation of TAMs and identify candidate targets for therapeutic intervention of glioma through bioinformatics analysis.Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) datasets were used to download RNA-Seq data and microarray data of human glioma specimen. Differentially expressed genes (DEGs) between CD68-high samples and CD68-low samples were sorted. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the DEGs was conducted. Protein-protein interaction (PPI) network were formed to identify the hub genes.The prognostic value of TAMs in glioma patients was confirmed. A total of 477 specific DEGs were sorted. The signaling pathway was identified in pathway enrichment and the DEGs showed prominent representations of immune response networks in glioma. The hub genes including C3, IL6, ITGB2, PTAFR, TIMP1 and VAMP8 were identified form the PPI network and they were all correlated positively with the expression of CD68 and showed the excellent prognostic value in glioma patients.TAMs can be used as a good prognostic indicator in glioma patients. By analyzing comprehensive bioinformatics data, we uncovered the underlying signaling pathway of the DEGs between glioma patients with high and low expression level of CD68. Furthermore, the 6 hub genes identified were closely associated with TAMs in glioma microenvironment and need further investigation." @default.
• W3111111518 created "2020-12-21" @default.
• W3111111518 creator A5008372795 @default.
• W3111111518 creator A5010417454 @default.
• W3111111518 creator A5019286475 @default.
• W3111111518 creator A5049464184 @default.
• W3111111518 creator A5067651606 @default.
• W3111111518 creator A5089567785 @default.
• W3111111518 date "2020-12-18" @default.
• W3111111518 modified "2023-09-27" @default.
• W3111111518 title "Tumor-associated macrophages based signaling pathway analysis and hub genes identification in glioma" @default.
• W3111111518 cites W1980485314 @default.
• W3111111518 cites W1992144732 @default.
• W3111111518 cites W1993762420 @default.
• W3111111518 cites W2009507529 @default.
• W3111111518 cites W2078792062 @default.
• W3111111518 cites W2109565161 @default.
• W3111111518 cites W2135404870 @default.
• W3111111518 cites W2140237552 @default.
• W3111111518 cites W2157207462 @default.
• W3111111518 cites W2167898988 @default.
• W3111111518 cites W2220215167 @default.
• W3111111518 cites W2308813426 @default.
• W3111111518 cites W2320620617 @default.
• W3111111518 cites W2359518746 @default.
• W3111111518 cites W2401143451 @default.
• W3111111518 cites W2404447925 @default.
• W3111111518 cites W2497241389 @default.
• W3111111518 cites W2512602895 @default.
• W3111111518 cites W2582686270 @default.
• W3111111518 cites W2605483677 @default.
• W3111111518 cites W2699091512 @default.
• W3111111518 cites W2748217844 @default.
• W3111111518 cites W2749747068 @default.
• W3111111518 cites W2767198352 @default.
• W3111111518 cites W2777206318 @default.
• W3111111518 cites W2782503894 @default.
• W3111111518 cites W2802299363 @default.
• W3111111518 cites W2808522237 @default.
• W3111111518 cites W2884876534 @default.
• W3111111518 cites W2889646458 @default.
• W3111111518 cites W2895926103 @default.
• W3111111518 cites W2896996016 @default.
• W3111111518 cites W2897261722 @default.
• W3111111518 cites W2898415660 @default.
• W3111111518 cites W2911746882 @default.
• W3111111518 cites W2911871569 @default.
• W3111111518 cites W2912342382 @default.
• W3111111518 cites W2917780715 @default.
• W3111111518 cites W2924849767 @default.
• W3111111518 cites W2930154557 @default.
• W3111111518 cites W2942894742 @default.
• W3111111518 cites W2951880440 @default.
• W3111111518 cites W2956024695 @default.
• W3111111518 cites W2959497269 @default.
• W3111111518 cites W2965482317 @default.
• W3111111518 cites W2982426375 @default.
• W3111111518 cites W3005107936 @default.
• W3111111518 cites W4250899941 @default.
• W3111111518 doi "https://doi.org/10.1097/md.0000000000023840" @default.
• W3111111518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7748342" @default.
• W3111111518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33371165" @default.
• W3111111518 hasPublicationYear "2020" @default.
• W3111111518 type Work @default.
• W3111111518 sameAs 3111111518 @default.
• W3111111518 citedByCount "3" @default.
• W3111111518 countsByYear W31111115182021 @default.
• W3111111518 countsByYear W31111115182022 @default.
• W3111111518 countsByYear W31111115182023 @default.
• W3111111518 crossrefType "journal-article" @default.
• W3111111518 hasAuthorship W3111111518A5008372795 @default.
• W3111111518 hasAuthorship W3111111518A5010417454 @default.
• W3111111518 hasAuthorship W3111111518A5019286475 @default.
• W3111111518 hasAuthorship W3111111518A5049464184 @default.
• W3111111518 hasAuthorship W3111111518A5067651606 @default.
• W3111111518 hasAuthorship W3111111518A5089567785 @default.
• W3111111518 hasBestOaLocation W31111115181 @default.
• W3111111518 hasConcept C104317684 @default.
• W3111111518 hasConcept C150194340 @default.
• W3111111518 hasConcept C152724338 @default.
• W3111111518 hasConcept C162317418 @default.
• W3111111518 hasConcept C2778227246 @default.
• W3111111518 hasConcept C502942594 @default.
• W3111111518 hasConcept C54355233 @default.
• W3111111518 hasConcept C62478195 @default.
• W3111111518 hasConcept C70721500 @default.
• W3111111518 hasConcept C71924100 @default.
• W3111111518 hasConcept C8415881 @default.
• W3111111518 hasConcept C86803240 @default.
• W3111111518 hasConceptScore W3111111518C104317684 @default.
• W3111111518 hasConceptScore W3111111518C150194340 @default.
• W3111111518 hasConceptScore W3111111518C152724338 @default.
• W3111111518 hasConceptScore W3111111518C162317418 @default.
• W3111111518 hasConceptScore W3111111518C2778227246 @default.
• W3111111518 hasConceptScore W3111111518C502942594 @default.
• W3111111518 hasConceptScore W3111111518C54355233 @default.
• W3111111518 hasConceptScore W3111111518C62478195 @default.
• W3111111518 hasConceptScore W3111111518C70721500 @default.

• next