Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111120246> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3111120246 abstract "Context Although postmenopausal hormone replacement (HRT) therapy is widely used, its risks and benefits are not well understood. Some observational data suggest that HRT may reduce the risk of cognitive decline and dementia but results have been conflicting. Objective To review and evaluate studies of HRT for preventing cognitive decline and dementia in healthy postmenopausal women. Data Sources Studies with English-language abstracts identified in MEDLINE (1966-December 2000), HealthSTAR (1975-December 2000), PsychINFO (1984-December 2000); Cochrane Library databases; and articles listed in reference lists of key articles. Study Selection Randomized controlled trials and cohort studies were reviewed for the effects of HRT on cognitive decline; cohort and case-control studies were reviewed for dementia risk. No randomized controlled trials regarding dementia risk were identified. Data Extraction Twenty-nine studies met inclusion criteria and were rated. Two reviewers rated study quality independently and 100% agreement was reached on Jadad scores and 80% agreement was reached on U.S. Preventive Services Task Force quality scores. A final score was reached through consensus if reviewers disagreed. Data Synthesis Studies of cognition were not combined quantitatively because of heterogeneous study design. Women symptomatic from menopause had improvements in verbal memory, vigilance, reasoning, and motor speed, but no enhancement of other cognitive functions. Generally, no benefits were observed in asymptomatic women. A Bayesian meta-analysis of 12 observational studies suggested that HRT was associated with a decreased risk of dementia (summary odds ratio, 0.66; 95% confidence interval, 0.53-0.82). However, possible biases and lack of control for potential confounders limit interpretation of these studies. Eight studies received a poor quality rating, 3 fair, and 1 good. Studies did not contain enough information to assess adequately the effects of progestin use, various estrogen preparations or doses, or duration of therapy. Conclusions In women with menopausal symptoms, HRT may have specific cognitive effects, and future studies should target these effects. The meta-analysis found a decreased risk of dementia in HRT users but most studies had important methodological limitations." @default.
- W3111120246 created "2020-12-21" @default.
- W3111120246 creator A5010408626 @default.
- W3111120246 creator A5010829414 @default.
- W3111120246 creator A5025557847 @default.
- W3111120246 date "2002-08-01" @default.
- W3111120246 modified "2023-09-27" @default.
- W3111120246 title "Hormone Replacement Therapy and Cognition [Internet]" @default.
- W3111120246 hasPublicationYear "2002" @default.
- W3111120246 type Work @default.
- W3111120246 sameAs 3111120246 @default.
- W3111120246 citedByCount "0" @default.
- W3111120246 crossrefType "journal-article" @default.
- W3111120246 hasAuthorship W3111120246A5010408626 @default.
- W3111120246 hasAuthorship W3111120246A5010829414 @default.
- W3111120246 hasAuthorship W3111120246A5025557847 @default.
- W3111120246 hasConcept C118552586 @default.
- W3111120246 hasConcept C126322002 @default.
- W3111120246 hasConcept C136524200 @default.
- W3111120246 hasConcept C151730666 @default.
- W3111120246 hasConcept C156957248 @default.
- W3111120246 hasConcept C168563851 @default.
- W3111120246 hasConcept C169900460 @default.
- W3111120246 hasConcept C201903717 @default.
- W3111120246 hasConcept C23131810 @default.
- W3111120246 hasConcept C2776478404 @default.
- W3111120246 hasConcept C2779134260 @default.
- W3111120246 hasConcept C2779343474 @default.
- W3111120246 hasConcept C2779483572 @default.
- W3111120246 hasConcept C71924100 @default.
- W3111120246 hasConcept C86803240 @default.
- W3111120246 hasConceptScore W3111120246C118552586 @default.
- W3111120246 hasConceptScore W3111120246C126322002 @default.
- W3111120246 hasConceptScore W3111120246C136524200 @default.
- W3111120246 hasConceptScore W3111120246C151730666 @default.
- W3111120246 hasConceptScore W3111120246C156957248 @default.
- W3111120246 hasConceptScore W3111120246C168563851 @default.
- W3111120246 hasConceptScore W3111120246C169900460 @default.
- W3111120246 hasConceptScore W3111120246C201903717 @default.
- W3111120246 hasConceptScore W3111120246C23131810 @default.
- W3111120246 hasConceptScore W3111120246C2776478404 @default.
- W3111120246 hasConceptScore W3111120246C2779134260 @default.
- W3111120246 hasConceptScore W3111120246C2779343474 @default.
- W3111120246 hasConceptScore W3111120246C2779483572 @default.
- W3111120246 hasConceptScore W3111120246C71924100 @default.
- W3111120246 hasConceptScore W3111120246C86803240 @default.
- W3111120246 hasLocation W31111202461 @default.
- W3111120246 hasOpenAccess W3111120246 @default.
- W3111120246 hasPrimaryLocation W31111202461 @default.
- W3111120246 hasRelatedWork W1934838668 @default.
- W3111120246 hasRelatedWork W2124406235 @default.
- W3111120246 hasRelatedWork W2281695020 @default.
- W3111120246 hasRelatedWork W2319359797 @default.
- W3111120246 hasRelatedWork W2611848487 @default.
- W3111120246 hasRelatedWork W2761304085 @default.
- W3111120246 hasRelatedWork W2815156057 @default.
- W3111120246 hasRelatedWork W2955240946 @default.
- W3111120246 hasRelatedWork W2996692586 @default.
- W3111120246 hasRelatedWork W2998654822 @default.
- W3111120246 hasRelatedWork W3003183569 @default.
- W3111120246 hasRelatedWork W3024218830 @default.
- W3111120246 hasRelatedWork W3091954907 @default.
- W3111120246 hasRelatedWork W3115818154 @default.
- W3111120246 hasRelatedWork W3126199390 @default.
- W3111120246 hasRelatedWork W3126593178 @default.
- W3111120246 hasRelatedWork W3159640056 @default.
- W3111120246 hasRelatedWork W3165098197 @default.
- W3111120246 hasRelatedWork W3192530077 @default.
- W3111120246 hasRelatedWork W3203713175 @default.
- W3111120246 isParatext "false" @default.
- W3111120246 isRetracted "false" @default.
- W3111120246 magId "3111120246" @default.
- W3111120246 workType "article" @default.