FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111132503> ?p ?o ?g. }

• W3111132503 abstract "Abstract Background Extracellular adenosine 5'-triphosphate (ATP) has been suggested to cause neuroinflammation and motor neuron degeneration by activating microglia and astrocytes in amyotrophic lateral sclerosis (ALS). Since we have developed a highly sensitive ATP assay system, we examined cerebrospinal fluid (CSF) ATP levels in patients with ALS whether it can be a useful biomarker in ALS. Methods Forty-eight CSF samples from 44 patients with ALS were assayed for ATP with a newly established, highly sensitive assay system using luciferase luminous reaction. CSF samples from patients with idiopathic normal pressure hydrocephalus (iNPH) were assayed as a control. Patients were divided into two groups depending on their disease severity, as evaluated using the Medical Research Council (MRC) sum score. Correlations between the CSF ATP levels and other factors, including clinical data and serum creatinine levels, were evaluated. Results CSF ATP levels were significantly higher in patients with ALS than in the iNPH (716 ± 411 vs. 3635 ± 5465 pmol/L, p < 0.01). CSF ATP levels were significantly higher in the more severe group than in the iNPH group (6860 ± 8312 vs. 716 ± 411 pmol/L, p < 0.05) and mild group (6860 ± 8312 vs. 2676 ± 3959 pmol/L, p < 0.05) respectively. ALS functional rating scale-revised (ALSFRS-R) (37.9 ± 5.7 vs. 42.4 ± 2.8, p < 0.01) and serum creatinine levels (0.51 ± 0.13 vs. 0.68 ± 0.23 mg/dL, p < 0.05) were significantly lower in the severe group than in the mild group respectively. A negative correlation of CSF ATP levels with MRC sum score was demonstrated in the correlation analysis adjusted for age and sex (r = -0.3, p = 0.08). Conclusions Extracellular ATP is particularly increased in the CSF of patients with advanced ALS. CSF ATP levels may be a useful biomarker for evaluating disease severity in patients with ALS." @default.
• W3111132503 created "2020-12-21" @default.
• W3111132503 creator A5000297625 @default.
• W3111132503 creator A5002180831 @default.
• W3111132503 creator A5009047627 @default.
• W3111132503 creator A5017989247 @default.
• W3111132503 creator A5033446220 @default.
• W3111132503 creator A5035992163 @default.
• W3111132503 creator A5038773672 @default.
• W3111132503 creator A5043376628 @default.
• W3111132503 creator A5049463019 @default.
• W3111132503 creator A5071376142 @default.
• W3111132503 creator A5078365883 @default.
• W3111132503 creator A5083908292 @default.
• W3111132503 date "2021-06-30" @default.
• W3111132503 modified "2023-10-10" @default.
• W3111132503 title "Increased cerebrospinal fluid adenosine 5'-triphosphate in patients with amyotrophic lateral sclerosis" @default.
• W3111132503 cites W1485797978 @default.
• W3111132503 cites W1569713122 @default.
• W3111132503 cites W1914037022 @default.
• W3111132503 cites W1983741516 @default.
• W3111132503 cites W2003618511 @default.
• W3111132503 cites W2007664874 @default.
• W3111132503 cites W2019702139 @default.
• W3111132503 cites W2020372793 @default.
• W3111132503 cites W2041034105 @default.
• W3111132503 cites W2051035876 @default.
• W3111132503 cites W2053410363 @default.
• W3111132503 cites W2077612318 @default.
• W3111132503 cites W2079823127 @default.
• W3111132503 cites W2093791199 @default.
• W3111132503 cites W2094021064 @default.
• W3111132503 cites W2098109360 @default.
• W3111132503 cites W2106315408 @default.
• W3111132503 cites W2130139478 @default.
• W3111132503 cites W2142064395 @default.
• W3111132503 cites W2143194752 @default.
• W3111132503 cites W2153955573 @default.
• W3111132503 cites W2157724221 @default.
• W3111132503 cites W2510418724 @default.
• W3111132503 cites W2565364815 @default.
• W3111132503 cites W2725805506 @default.
• W3111132503 cites W2766294912 @default.
• W3111132503 cites W2807994038 @default.
• W3111132503 cites W2901284038 @default.
• W3111132503 cites W2949014264 @default.
• W3111132503 cites W2950589943 @default.
• W3111132503 cites W2989641740 @default.
• W3111132503 cites W2991542595 @default.
• W3111132503 cites W3015325769 @default.
• W3111132503 cites W3034461038 @default.
• W3111132503 cites W4252979096 @default.
• W3111132503 cites W818915126 @default.
• W3111132503 doi "https://doi.org/10.1186/s12883-021-02288-4" @default.
• W3111132503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8243489" @default.
• W3111132503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34193068" @default.
• W3111132503 hasPublicationYear "2021" @default.
• W3111132503 type Work @default.
• W3111132503 sameAs 3111132503 @default.
• W3111132503 citedByCount "2" @default.
• W3111132503 countsByYear W31111325032022 @default.
• W3111132503 crossrefType "journal-article" @default.
• W3111132503 hasAuthorship W3111132503A5000297625 @default.
• W3111132503 hasAuthorship W3111132503A5002180831 @default.
• W3111132503 hasAuthorship W3111132503A5009047627 @default.
• W3111132503 hasAuthorship W3111132503A5017989247 @default.
• W3111132503 hasAuthorship W3111132503A5033446220 @default.
• W3111132503 hasAuthorship W3111132503A5035992163 @default.
• W3111132503 hasAuthorship W3111132503A5038773672 @default.
• W3111132503 hasAuthorship W3111132503A5043376628 @default.
• W3111132503 hasAuthorship W3111132503A5049463019 @default.
• W3111132503 hasAuthorship W3111132503A5071376142 @default.
• W3111132503 hasAuthorship W3111132503A5078365883 @default.
• W3111132503 hasAuthorship W3111132503A5083908292 @default.
• W3111132503 hasBestOaLocation W31111325031 @default.
• W3111132503 hasConcept C118552586 @default.
• W3111132503 hasConcept C126322002 @default.
• W3111132503 hasConcept C134018914 @default.
• W3111132503 hasConcept C142724271 @default.
• W3111132503 hasConcept C16568411 @default.
• W3111132503 hasConcept C185592680 @default.
• W3111132503 hasConcept C2779134260 @default.
• W3111132503 hasConcept C2779564974 @default.
• W3111132503 hasConcept C2779651940 @default.
• W3111132503 hasConcept C2780306776 @default.
• W3111132503 hasConcept C2780596555 @default.
• W3111132503 hasConcept C2781197716 @default.
• W3111132503 hasConcept C55493867 @default.
• W3111132503 hasConcept C71924100 @default.
• W3111132503 hasConcept C87753298 @default.
• W3111132503 hasConcept C90924648 @default.
• W3111132503 hasConceptScore W3111132503C118552586 @default.
• W3111132503 hasConceptScore W3111132503C126322002 @default.
• W3111132503 hasConceptScore W3111132503C134018914 @default.
• W3111132503 hasConceptScore W3111132503C142724271 @default.
• W3111132503 hasConceptScore W3111132503C16568411 @default.
• W3111132503 hasConceptScore W3111132503C185592680 @default.
• W3111132503 hasConceptScore W3111132503C2779134260 @default.
• W3111132503 hasConceptScore W3111132503C2779564974 @default.
• W3111132503 hasConceptScore W3111132503C2779651940 @default.

• next