FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111156556> ?p ?o ?g. }

• W3111156556 abstract "Abstract Background Approximately 5% of the 5.6 million (∼280,000) Americans with Alzheimer’s disease (AD) develop symptoms at age 65 or younger and are classified as having early‐onset AD (EOAD). Although EOAD and late‐onset AD (LOAD) share the same pathologic substrate, there are notable differences in their clinical and biological phenotypes. The Longitudinal Early‐onset AD study (LEADS) is a multi‐site, observational clinical and biomarker study of EOAD. In the present study we utilized the currently available LEADS imaging data to explore the spatial extent and magnitude of neurodegeneration EOAD Method 95 amyloid positive patients with EOAD, 37 amyloid negative cognitively impaired patients (EOnonAD) , and 55 cognitively unimpaired controls (CNs) were included in the analysis. The magnitude of cortical thinning in the EOAD and EOnonAD groups was estimated using whole‐brain GLMs compared to the CN group. In addition, w‐scores were derived for each EOAD patient for these ROIs: average cortical thickness, hippocampal volume, AD‐signature cortical thickness (typically used in LOAD), and precuneus cortical thickness controlling for age, sex, and acquisition site. The utility of each ROI to differentiate EOAD patients from CNs was assessed by calculating the percentage of patients falling below a W‐threshold of ‐1.5. Result In EOAD, a distributed pattern of cortical thinning was observed in lateral temporal, parietal, and frontal cortex (p<.01), and was most prominent in the precuneus (Cohen’s d’ = 1.5). In the EOnonAD group, cortical thinning was observed but was highly variable across individuals. The w‐score analysis in the EOAD group yielded the following results: Mean Cortical thickness: Mean = ‐3.34, SD = 2.97, Classification = 72%.; Hippocampal volume: Mean = ‐2.96, SD = 2.39, Classification = 74%; AD Signature: Mean = ‐4.63, SD = 3.07, Classification = 80%; Precuneus: Mean = ‐5.98, SD = 4.1, Classification = 90%. Conclusion Our results are consistent with previous findings demonstrating cortical thinning in lateral parietal, precuneus, and lateral temporal lobes in EOAD with relatively less involvement of the medial temporal lobes. Our results also suggest that the precuneus may be especially vulnerable to neurodegeneration in patients with EOAD and may serve as a useful biomarker for patient classification." @default.
• W3111156556 created "2020-12-21" @default.
• W3111156556 creator A5002183686 @default.
• W3111156556 creator A5003680013 @default.
• W3111156556 creator A5004744435 @default.
• W3111156556 creator A5005099850 @default.
• W3111156556 creator A5014949118 @default.
• W3111156556 creator A5016730229 @default.
• W3111156556 creator A5022778785 @default.
• W3111156556 creator A5023107114 @default.
• W3111156556 creator A5024419194 @default.
• W3111156556 creator A5025837253 @default.
• W3111156556 creator A5026257338 @default.
• W3111156556 creator A5027031712 @default.
• W3111156556 creator A5028700638 @default.
• W3111156556 creator A5033942521 @default.
• W3111156556 creator A5034225628 @default.
• W3111156556 creator A5041387594 @default.
• W3111156556 creator A5043921358 @default.
• W3111156556 creator A5046430509 @default.
• W3111156556 creator A5046803794 @default.
• W3111156556 creator A5048034644 @default.
• W3111156556 creator A5050848678 @default.
• W3111156556 creator A5052536571 @default.
• W3111156556 creator A5053994505 @default.
• W3111156556 creator A5059469170 @default.
• W3111156556 creator A5061904358 @default.
• W3111156556 creator A5063381985 @default.
• W3111156556 creator A5063489595 @default.
• W3111156556 creator A5074477451 @default.
• W3111156556 creator A5080419931 @default.
• W3111156556 creator A5080505451 @default.
• W3111156556 creator A5083886913 @default.
• W3111156556 creator A5087482235 @default.
• W3111156556 creator A5091046259 @default.
• W3111156556 date "2020-12-01" @default.
• W3111156556 modified "2023-09-29" @default.
• W3111156556 title "Neurodegeneration in the Longitudinal Evaluation of Early Onset Alzheimer’s Disease Study (LEADS) sample: Results from the MRI core" @default.
• W3111156556 doi "https://doi.org/10.1002/alz.046338" @default.
• W3111156556 hasPublicationYear "2020" @default.
• W3111156556 type Work @default.
• W3111156556 sameAs 3111156556 @default.
• W3111156556 citedByCount "0" @default.
• W3111156556 crossrefType "journal-article" @default.
• W3111156556 hasAuthorship W3111156556A5002183686 @default.
• W3111156556 hasAuthorship W3111156556A5003680013 @default.
• W3111156556 hasAuthorship W3111156556A5004744435 @default.
• W3111156556 hasAuthorship W3111156556A5005099850 @default.
• W3111156556 hasAuthorship W3111156556A5014949118 @default.
• W3111156556 hasAuthorship W3111156556A5016730229 @default.
• W3111156556 hasAuthorship W3111156556A5022778785 @default.
• W3111156556 hasAuthorship W3111156556A5023107114 @default.
• W3111156556 hasAuthorship W3111156556A5024419194 @default.
• W3111156556 hasAuthorship W3111156556A5025837253 @default.
• W3111156556 hasAuthorship W3111156556A5026257338 @default.
• W3111156556 hasAuthorship W3111156556A5027031712 @default.
• W3111156556 hasAuthorship W3111156556A5028700638 @default.
• W3111156556 hasAuthorship W3111156556A5033942521 @default.
• W3111156556 hasAuthorship W3111156556A5034225628 @default.
• W3111156556 hasAuthorship W3111156556A5041387594 @default.
• W3111156556 hasAuthorship W3111156556A5043921358 @default.
• W3111156556 hasAuthorship W3111156556A5046430509 @default.
• W3111156556 hasAuthorship W3111156556A5046803794 @default.
• W3111156556 hasAuthorship W3111156556A5048034644 @default.
• W3111156556 hasAuthorship W3111156556A5050848678 @default.
• W3111156556 hasAuthorship W3111156556A5052536571 @default.
• W3111156556 hasAuthorship W3111156556A5053994505 @default.
• W3111156556 hasAuthorship W3111156556A5059469170 @default.
• W3111156556 hasAuthorship W3111156556A5061904358 @default.
• W3111156556 hasAuthorship W3111156556A5063381985 @default.
• W3111156556 hasAuthorship W3111156556A5063489595 @default.
• W3111156556 hasAuthorship W3111156556A5074477451 @default.
• W3111156556 hasAuthorship W3111156556A5080419931 @default.
• W3111156556 hasAuthorship W3111156556A5080505451 @default.
• W3111156556 hasAuthorship W3111156556A5083886913 @default.
• W3111156556 hasAuthorship W3111156556A5087482235 @default.
• W3111156556 hasAuthorship W3111156556A5091046259 @default.
• W3111156556 hasBestOaLocation W31111565561 @default.
• W3111156556 hasConcept C126322002 @default.
• W3111156556 hasConcept C15744967 @default.
• W3111156556 hasConcept C169760540 @default.
• W3111156556 hasConcept C169900460 @default.
• W3111156556 hasConcept C2776925932 @default.
• W3111156556 hasConcept C2779134260 @default.
• W3111156556 hasConcept C2779483572 @default.
• W3111156556 hasConcept C2781340033 @default.
• W3111156556 hasConcept C2781441883 @default.
• W3111156556 hasConcept C502032728 @default.
• W3111156556 hasConcept C71924100 @default.
• W3111156556 hasConceptScore W3111156556C126322002 @default.
• W3111156556 hasConceptScore W3111156556C15744967 @default.
• W3111156556 hasConceptScore W3111156556C169760540 @default.
• W3111156556 hasConceptScore W3111156556C169900460 @default.
• W3111156556 hasConceptScore W3111156556C2776925932 @default.
• W3111156556 hasConceptScore W3111156556C2779134260 @default.
• W3111156556 hasConceptScore W3111156556C2779483572 @default.
• W3111156556 hasConceptScore W3111156556C2781340033 @default.
• W3111156556 hasConceptScore W3111156556C2781441883 @default.
• W3111156556 hasConceptScore W3111156556C502032728 @default.
• W3111156556 hasConceptScore W3111156556C71924100 @default.

• next