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- W3111160319 endingPage "672" @default.
- W3111160319 startingPage "655" @default.
- W3111160319 abstract "Introduction: The main role of preservatives in eyedrops is to ensure sterility and microbiological integrity of the drug, and to facilitate the penetration of active compounds into the eye. However, several studies documented significant toxic effects induced by preservatives, especially on the ocular surface. Consequently, most of the ophthalmic medications became progressively available in preservative-free (PF) formulations.Areas covered: We analyzed pre-clinical and clinical studies on PF eyedrops with particular attention to common chronic diseases such as dry eye and glaucoma. We discussed about the pros and cons of using PF eyedrops, in terms of efficacy, safety, and social-economic aspects.Expert opinion: There are still unresolved issues that make hard for PF medications to definitively conquer the drug market. Despite robust pre-clinical evidences of less toxicity, the low number of randomized clinical trials does not permit to state that PF eyedrops have, in clinical practice, a similar efficacy or a higher safety compared to preserved forms. These aspects limit their use to chronic diseases requiring long-term therapies with multiple daily instillations, especially in the presence of concomitant ophthalmic diseases that expose to a risk of ocular surface worsening." @default.
- W3111160319 created "2020-12-21" @default.
- W3111160319 creator A5010294522 @default.
- W3111160319 creator A5010737107 @default.
- W3111160319 creator A5043526873 @default.
- W3111160319 creator A5053492340 @default.
- W3111160319 creator A5060870428 @default.
- W3111160319 creator A5069030239 @default.
- W3111160319 creator A5085804289 @default.
- W3111160319 date "2020-12-16" @default.
- W3111160319 modified "2023-09-29" @default.
- W3111160319 title "Topical preservative-free ophthalmic treatments: an unmet clinical need" @default.
- W3111160319 cites W108592806 @default.
- W3111160319 cites W1452528154 @default.
- W3111160319 cites W1506011729 @default.
- W3111160319 cites W1855379264 @default.
- W3111160319 cites W1876746183 @default.
- W3111160319 cites W1964891082 @default.
- W3111160319 cites W1966579626 @default.
- W3111160319 cites W1966999230 @default.
- W3111160319 cites W1967031111 @default.
- W3111160319 cites W1968790499 @default.
- W3111160319 cites W1969453607 @default.
- W3111160319 cites W1972250185 @default.
- W3111160319 cites W1972517249 @default.
- W3111160319 cites W1972568474 @default.
- W3111160319 cites W1973633538 @default.
- W3111160319 cites W1974991464 @default.
- W3111160319 cites W1975142415 @default.
- W3111160319 cites W1976625008 @default.
- W3111160319 cites W1980538489 @default.
- W3111160319 cites W1982396479 @default.
- W3111160319 cites W1982535410 @default.
- W3111160319 cites W1987172167 @default.
- W3111160319 cites W1987281669 @default.
- W3111160319 cites W1988436988 @default.
- W3111160319 cites W1988519672 @default.
- W3111160319 cites W1989336709 @default.
- W3111160319 cites W1989462542 @default.
- W3111160319 cites W1992445198 @default.
- W3111160319 cites W1993350635 @default.
- W3111160319 cites W1997494713 @default.
- W3111160319 cites W2001963731 @default.
- W3111160319 cites W2003117135 @default.
- W3111160319 cites W2003892344 @default.
- W3111160319 cites W2009259670 @default.
- W3111160319 cites W2011177839 @default.
- W3111160319 cites W2013270615 @default.
- W3111160319 cites W2014974068 @default.
- W3111160319 cites W2015769584 @default.
- W3111160319 cites W2019431885 @default.
- W3111160319 cites W2019874252 @default.
- W3111160319 cites W2019981047 @default.
- W3111160319 cites W2021625340 @default.
- W3111160319 cites W2022635325 @default.
- W3111160319 cites W2022829262 @default.
- W3111160319 cites W2023505429 @default.
- W3111160319 cites W2025742823 @default.
- W3111160319 cites W2027356236 @default.
- W3111160319 cites W2027991725 @default.
- W3111160319 cites W2030694257 @default.
- W3111160319 cites W2033650789 @default.
- W3111160319 cites W2035689780 @default.
- W3111160319 cites W2036341177 @default.
- W3111160319 cites W2040006290 @default.
- W3111160319 cites W2041930305 @default.
- W3111160319 cites W2045141901 @default.
- W3111160319 cites W2045385884 @default.
- W3111160319 cites W2047745647 @default.
- W3111160319 cites W2048991035 @default.
- W3111160319 cites W2050127291 @default.
- W3111160319 cites W2050551788 @default.
- W3111160319 cites W2054278111 @default.
- W3111160319 cites W2058036002 @default.
- W3111160319 cites W2059492321 @default.
- W3111160319 cites W2059897265 @default.
- W3111160319 cites W2060454631 @default.
- W3111160319 cites W2064280255 @default.
- W3111160319 cites W2066361200 @default.
- W3111160319 cites W2067609364 @default.
- W3111160319 cites W2067611847 @default.
- W3111160319 cites W2067834740 @default.
- W3111160319 cites W2068119665 @default.
- W3111160319 cites W2069425903 @default.
- W3111160319 cites W2072021875 @default.
- W3111160319 cites W2072870676 @default.
- W3111160319 cites W2076430752 @default.
- W3111160319 cites W2076545982 @default.
- W3111160319 cites W2077751824 @default.
- W3111160319 cites W2078429928 @default.
- W3111160319 cites W2081524379 @default.
- W3111160319 cites W2082160708 @default.
- W3111160319 cites W2087162058 @default.
- W3111160319 cites W2088887129 @default.
- W3111160319 cites W2091630088 @default.
- W3111160319 cites W2094354059 @default.
- W3111160319 cites W2108069709 @default.
- W3111160319 cites W2116581063 @default.