FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111176459> ?p ?o ?g. }

• W3111176459 abstract "Abstract Mixtures of biological macromolecules are inherently difficult to study using structural methods, as increasing complexity presents new challenges for data analysis. Recently, there has been growing interest in studying evolving mixtures using small-angle X-ray scattering (SAXS) in conjunction with time-resolved, high-throughput, or chromatography-coupled setups. Deconvolution and interpretation of the resulting datasets, however, are nontrivial when neither the scattering components nor the way in which they evolve are known a priori. To address this issue, we introduce the REGALS method (REGularized Alternating Least Squares), which incorporates simple expectations about the data as prior knowledge and utilizes parameterization and regularization to provide robust deconvolution solutions. The restraints used by REGALS are general properties such as smoothness of profiles and maximum dimensions of species, which makes it well-suited for exploring datasets with unknown species. Here we apply REGALS to analyze experimental data from four types of SAXS experiment: anion-exchange (AEX) coupled SAXS, ligand titration, time-resolved mixing, and time-resolved temperature jump. Based on its performance with these challenging datasets, we anticipate that REGALS will be a valuable addition to the SAXS analysis toolkit and enable new experiments. The software is implemented in both MATLAB and python and is available freely as an open-source software package." @default.
• W3111176459 created "2020-12-21" @default.
• W3111176459 creator A5019528030 @default.
• W3111176459 creator A5025675621 @default.
• W3111176459 creator A5045818589 @default.
• W3111176459 date "2020-12-07" @default.
• W3111176459 modified "2023-09-23" @default.
• W3111176459 title "REGALS: a general method to deconvolve X-ray scattering data from evolving mixtures" @default.
• W3111176459 cites W1591346633 @default.
• W3111176459 cites W1964352165 @default.
• W3111176459 cites W1975361133 @default.
• W3111176459 cites W1982126789 @default.
• W3111176459 cites W1983670463 @default.
• W3111176459 cites W1988500449 @default.
• W3111176459 cites W1996122875 @default.
• W3111176459 cites W1999602967 @default.
• W3111176459 cites W2000141885 @default.
• W3111176459 cites W2001492509 @default.
• W3111176459 cites W2001926601 @default.
• W3111176459 cites W2012233421 @default.
• W3111176459 cites W2017188882 @default.
• W3111176459 cites W2019820636 @default.
• W3111176459 cites W2030405813 @default.
• W3111176459 cites W2048955200 @default.
• W3111176459 cites W2049740050 @default.
• W3111176459 cites W204991446 @default.
• W3111176459 cites W2056440784 @default.
• W3111176459 cites W2066034539 @default.
• W3111176459 cites W2081826205 @default.
• W3111176459 cites W2082505332 @default.
• W3111176459 cites W2097143471 @default.
• W3111176459 cites W2099373664 @default.
• W3111176459 cites W2106771705 @default.
• W3111176459 cites W2113227718 @default.
• W3111176459 cites W2142654956 @default.
• W3111176459 cites W2345449302 @default.
• W3111176459 cites W2521032208 @default.
• W3111176459 cites W2555287254 @default.
• W3111176459 cites W2620265724 @default.
• W3111176459 cites W2753348948 @default.
• W3111176459 cites W2802102766 @default.
• W3111176459 cites W2911546748 @default.
• W3111176459 cites W2950020601 @default.
• W3111176459 cites W2973781617 @default.
• W3111176459 cites W2997012586 @default.
• W3111176459 doi "https://doi.org/10.1101/2020.12.06.413997" @default.
• W3111176459 hasPublicationYear "2020" @default.
• W3111176459 type Work @default.
• W3111176459 sameAs 3111176459 @default.
• W3111176459 citedByCount "0" @default.
• W3111176459 crossrefType "posted-content" @default.
• W3111176459 hasAuthorship W3111176459A5019528030 @default.
• W3111176459 hasAuthorship W3111176459A5025675621 @default.
• W3111176459 hasAuthorship W3111176459A5045818589 @default.
• W3111176459 hasBestOaLocation W31111764591 @default.
• W3111176459 hasConcept C111472728 @default.
• W3111176459 hasConcept C111919701 @default.
• W3111176459 hasConcept C11413529 @default.
• W3111176459 hasConcept C120665830 @default.
• W3111176459 hasConcept C121332964 @default.
• W3111176459 hasConcept C124101348 @default.
• W3111176459 hasConcept C131888329 @default.
• W3111176459 hasConcept C138885662 @default.
• W3111176459 hasConcept C174576160 @default.
• W3111176459 hasConcept C186060115 @default.
• W3111176459 hasConcept C191486275 @default.
• W3111176459 hasConcept C199360897 @default.
• W3111176459 hasConcept C2777904410 @default.
• W3111176459 hasConcept C2780365114 @default.
• W3111176459 hasConcept C41008148 @default.
• W3111176459 hasConcept C459310 @default.
• W3111176459 hasConcept C519991488 @default.
• W3111176459 hasConcept C75553542 @default.
• W3111176459 hasConcept C86803240 @default.
• W3111176459 hasConceptScore W3111176459C111472728 @default.
• W3111176459 hasConceptScore W3111176459C111919701 @default.
• W3111176459 hasConceptScore W3111176459C11413529 @default.
• W3111176459 hasConceptScore W3111176459C120665830 @default.
• W3111176459 hasConceptScore W3111176459C121332964 @default.
• W3111176459 hasConceptScore W3111176459C124101348 @default.
• W3111176459 hasConceptScore W3111176459C131888329 @default.
• W3111176459 hasConceptScore W3111176459C138885662 @default.
• W3111176459 hasConceptScore W3111176459C174576160 @default.
• W3111176459 hasConceptScore W3111176459C186060115 @default.
• W3111176459 hasConceptScore W3111176459C191486275 @default.
• W3111176459 hasConceptScore W3111176459C199360897 @default.
• W3111176459 hasConceptScore W3111176459C2777904410 @default.
• W3111176459 hasConceptScore W3111176459C2780365114 @default.
• W3111176459 hasConceptScore W3111176459C41008148 @default.
• W3111176459 hasConceptScore W3111176459C459310 @default.
• W3111176459 hasConceptScore W3111176459C519991488 @default.
• W3111176459 hasConceptScore W3111176459C75553542 @default.
• W3111176459 hasConceptScore W3111176459C86803240 @default.
• W3111176459 hasLocation W31111764591 @default.
• W3111176459 hasLocation W31111764592 @default.
• W3111176459 hasOpenAccess W3111176459 @default.
• W3111176459 hasPrimaryLocation W31111764591 @default.
• W3111176459 hasRelatedWork W1086594 @default.
• W3111176459 hasRelatedWork W11255425 @default.
• W3111176459 hasRelatedWork W11335181 @default.

• next