FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111187263> ?p ?o ?g. }

• W3111187263 endingPage "104317" @default.
• W3111187263 startingPage "104317" @default.
• W3111187263 abstract "Breast cancer is a complex cancer which includes many different subtypes. Identifying prognostic modules, i.e., functionally related gene networks that play crucial roles in cancer development is essential in breast cancer study. Different subtypes of breast cancer correspond to different treatment methods. The purpose of this study is to use a new method to divide breast cancer into different prognostic modules, so as to provide scientific basis for improving clinical management. The method is based on comparing similarities between modules detected from different weighted gene co-expression networks. The method was applied on genomic data of breast cancer from The Cancer Genome Atlas database and was applied to select differential modules between two groups of patients with significant differences in survival times. It was compared with a previously proposed module selection method. The result shows that our method outperforms the previously proposed one. Moreover, within the identified two differential modules, the first one is highly enriched with genes involved in hormone responds, the second one is highly related with biological process engaged in M-phase. The two modules were further validated by log-rank test in the validation dataset GSE3494. Both of the two modules show significantly different with p-values less than 0.02. The identified two modules confirmed previous findings including importance of biological networks in breast cancer involved in hormone response and M-phase. Out of the top twenty hub genes in the two modules, fifteen genes were previously shown to be prognostic markers for breast cancer." @default.
• W3111187263 created "2020-12-21" @default.
• W3111187263 creator A5018031443 @default.
• W3111187263 creator A5038935592 @default.
• W3111187263 creator A5061152137 @default.
• W3111187263 creator A5071896176 @default.
• W3111187263 date "2021-01-01" @default.
• W3111187263 modified "2023-10-16" @default.
• W3111187263 title "Identification of breast cancer prognostic modules via differential module selection based on weighted gene Co-expression network analysis" @default.
• W3111187263 cites W1881717934 @default.
• W3111187263 cites W1906628387 @default.
• W3111187263 cites W1966327575 @default.
• W3111187263 cites W1969804788 @default.
• W3111187263 cites W1972010889 @default.
• W3111187263 cites W1974637770 @default.
• W3111187263 cites W2021597940 @default.
• W3111187263 cites W2049531974 @default.
• W3111187263 cites W2060705109 @default.
• W3111187263 cites W2087900638 @default.
• W3111187263 cites W2111758831 @default.
• W3111187263 cites W2122185352 @default.
• W3111187263 cites W2122394460 @default.
• W3111187263 cites W2122673439 @default.
• W3111187263 cites W2130779727 @default.
• W3111187263 cites W2133465414 @default.
• W3111187263 cites W2141393790 @default.
• W3111187263 cites W2145391392 @default.
• W3111187263 cites W2148291626 @default.
• W3111187263 cites W2149594317 @default.
• W3111187263 cites W2158217645 @default.
• W3111187263 cites W2159586731 @default.
• W3111187263 cites W2160772231 @default.
• W3111187263 cites W2179237675 @default.
• W3111187263 cites W2272984102 @default.
• W3111187263 cites W2402022701 @default.
• W3111187263 cites W2564788625 @default.
• W3111187263 cites W2604586440 @default.
• W3111187263 cites W2755069190 @default.
• W3111187263 cites W2759105832 @default.
• W3111187263 cites W2762334214 @default.
• W3111187263 cites W2776482217 @default.
• W3111187263 cites W2783523809 @default.
• W3111187263 cites W2800085010 @default.
• W3111187263 cites W2912731945 @default.
• W3111187263 cites W2912904880 @default.
• W3111187263 cites W2945814640 @default.
• W3111187263 cites W2952605821 @default.
• W3111187263 cites W2957422120 @default.
• W3111187263 cites W3147586197 @default.
• W3111187263 doi "https://doi.org/10.1016/j.biosystems.2020.104317" @default.
• W3111187263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33279569" @default.
• W3111187263 hasPublicationYear "2021" @default.
• W3111187263 type Work @default.
• W3111187263 sameAs 3111187263 @default.
• W3111187263 citedByCount "2" @default.
• W3111187263 countsByYear W31111872632021 @default.
• W3111187263 countsByYear W31111872632022 @default.
• W3111187263 crossrefType "journal-article" @default.
• W3111187263 hasAuthorship W3111187263A5018031443 @default.
• W3111187263 hasAuthorship W3111187263A5038935592 @default.
• W3111187263 hasAuthorship W3111187263A5061152137 @default.
• W3111187263 hasAuthorship W3111187263A5071896176 @default.
• W3111187263 hasConcept C104317684 @default.
• W3111187263 hasConcept C116834253 @default.
• W3111187263 hasConcept C119857082 @default.
• W3111187263 hasConcept C121608353 @default.
• W3111187263 hasConcept C143998085 @default.
• W3111187263 hasConcept C150194340 @default.
• W3111187263 hasConcept C2778022302 @default.
• W3111187263 hasConcept C2987395477 @default.
• W3111187263 hasConcept C41008148 @default.
• W3111187263 hasConcept C530470458 @default.
• W3111187263 hasConcept C54355233 @default.
• W3111187263 hasConcept C59822182 @default.
• W3111187263 hasConcept C70721500 @default.
• W3111187263 hasConcept C71924100 @default.
• W3111187263 hasConcept C81917197 @default.
• W3111187263 hasConcept C86803240 @default.
• W3111187263 hasConceptScore W3111187263C104317684 @default.
• W3111187263 hasConceptScore W3111187263C116834253 @default.
• W3111187263 hasConceptScore W3111187263C119857082 @default.
• W3111187263 hasConceptScore W3111187263C121608353 @default.
• W3111187263 hasConceptScore W3111187263C143998085 @default.
• W3111187263 hasConceptScore W3111187263C150194340 @default.
• W3111187263 hasConceptScore W3111187263C2778022302 @default.
• W3111187263 hasConceptScore W3111187263C2987395477 @default.
• W3111187263 hasConceptScore W3111187263C41008148 @default.
• W3111187263 hasConceptScore W3111187263C530470458 @default.
• W3111187263 hasConceptScore W3111187263C54355233 @default.
• W3111187263 hasConceptScore W3111187263C59822182 @default.
• W3111187263 hasConceptScore W3111187263C70721500 @default.
• W3111187263 hasConceptScore W3111187263C71924100 @default.
• W3111187263 hasConceptScore W3111187263C81917197 @default.
• W3111187263 hasConceptScore W3111187263C86803240 @default.
• W3111187263 hasFunder F4320333688 @default.
• W3111187263 hasFunder F4320335473 @default.
• W3111187263 hasLocation W31111872631 @default.
• W3111187263 hasOpenAccess W3111187263 @default.

• next