Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111249725> ?p ?o ?g. }
- W3111249725 endingPage "2627" @default.
- W3111249725 startingPage "2627" @default.
- W3111249725 abstract "B lymphocytes are crucial mediators of systemic immune responses and are known to be substantial in the pathogenesis of autoimmune diseases with cutaneous manifestations. Amongst them are lupus erythematosus, dermatomyositis, systemic sclerosis and psoriasis, and particularly those driven by autoantibodies such as pemphigus and pemphigoid. However, the concept of autoreactive skin-associated B cells, which may reside in the skin and locally contribute to chronic inflammation, is gradually evolving. These cells are believed to differ from B cells of primary and secondary lymphoid organs and may provide additional features besides autoantibody production, including cytokine expression and crosstalk to autoreactive T cells in an antigen-presenting manner. In chronically inflamed skin, B cells may appear in tertiary lymphoid structures. Those abnormal lymph node-like structures comprise a network of immune and stromal cells possibly enriched by vascular structures and thus constitute an ideal niche for local autoimmune responses. In this review, we describe current considerations of different B cell subsets and their assumed role in skin autoimmunity. Moreover, we discuss traditional and B cell-associated approaches for the treatment of autoimmune skin diseases, including drugs targeting B cells (e.g., CD19- and CD20-antibodies), plasma cells (e.g., proteasome inhibitors, CXCR4 antagonists), activated pathways (such as BTK- and PI3K-inhibitors) and associated activator molecules (BLyS, APRIL)." @default.
- W3111249725 created "2020-12-21" @default.
- W3111249725 creator A5018615558 @default.
- W3111249725 creator A5066833785 @default.
- W3111249725 creator A5077775755 @default.
- W3111249725 creator A5089846663 @default.
- W3111249725 date "2020-12-07" @default.
- W3111249725 modified "2023-09-26" @default.
- W3111249725 title "Skin-Associated B Cells in the Pathogenesis of Cutaneous Autoimmune Diseases—Implications for Therapeutic Approaches" @default.
- W3111249725 cites W1488642813 @default.
- W3111249725 cites W1493876987 @default.
- W3111249725 cites W1503420941 @default.
- W3111249725 cites W1508360975 @default.
- W3111249725 cites W1509863491 @default.
- W3111249725 cites W1521119381 @default.
- W3111249725 cites W1521425219 @default.
- W3111249725 cites W1526240011 @default.
- W3111249725 cites W1551963675 @default.
- W3111249725 cites W1561311381 @default.
- W3111249725 cites W1611185316 @default.
- W3111249725 cites W163503699 @default.
- W3111249725 cites W1641790357 @default.
- W3111249725 cites W1696546567 @default.
- W3111249725 cites W1725503312 @default.
- W3111249725 cites W1806127905 @default.
- W3111249725 cites W1869200070 @default.
- W3111249725 cites W1897379845 @default.
- W3111249725 cites W1899066263 @default.
- W3111249725 cites W1925989912 @default.
- W3111249725 cites W1926541123 @default.
- W3111249725 cites W1936038771 @default.
- W3111249725 cites W1936873564 @default.
- W3111249725 cites W1964267502 @default.
- W3111249725 cites W1971473212 @default.
- W3111249725 cites W1972926811 @default.
- W3111249725 cites W1973380251 @default.
- W3111249725 cites W1973731651 @default.
- W3111249725 cites W1975772698 @default.
- W3111249725 cites W1976302032 @default.
- W3111249725 cites W1976534411 @default.
- W3111249725 cites W1977070803 @default.
- W3111249725 cites W1977271544 @default.
- W3111249725 cites W1978790143 @default.
- W3111249725 cites W1979602138 @default.
- W3111249725 cites W1980863018 @default.
- W3111249725 cites W1981003679 @default.
- W3111249725 cites W1982411778 @default.
- W3111249725 cites W1983339176 @default.
- W3111249725 cites W1984518402 @default.
- W3111249725 cites W1987076250 @default.
- W3111249725 cites W1987218173 @default.
- W3111249725 cites W1988411489 @default.
- W3111249725 cites W1988476615 @default.
- W3111249725 cites W1988928788 @default.
- W3111249725 cites W1991869743 @default.
- W3111249725 cites W1995703209 @default.
- W3111249725 cites W1999188722 @default.
- W3111249725 cites W1999213889 @default.
- W3111249725 cites W2001313261 @default.
- W3111249725 cites W2002035122 @default.
- W3111249725 cites W2003955825 @default.
- W3111249725 cites W2004804582 @default.
- W3111249725 cites W2006019631 @default.
- W3111249725 cites W2006945670 @default.
- W3111249725 cites W2007886976 @default.
- W3111249725 cites W2008891564 @default.
- W3111249725 cites W2009686145 @default.
- W3111249725 cites W2011444435 @default.
- W3111249725 cites W2012174763 @default.
- W3111249725 cites W2012228539 @default.
- W3111249725 cites W2016054852 @default.
- W3111249725 cites W2016273346 @default.
- W3111249725 cites W2017744684 @default.
- W3111249725 cites W2019808150 @default.
- W3111249725 cites W2020806642 @default.
- W3111249725 cites W2021257197 @default.
- W3111249725 cites W2024263224 @default.
- W3111249725 cites W2027226325 @default.
- W3111249725 cites W2028514870 @default.
- W3111249725 cites W2029546562 @default.
- W3111249725 cites W2032300322 @default.
- W3111249725 cites W2034293576 @default.
- W3111249725 cites W2038057062 @default.
- W3111249725 cites W2040088422 @default.
- W3111249725 cites W2040876247 @default.
- W3111249725 cites W2041905689 @default.
- W3111249725 cites W2043454321 @default.
- W3111249725 cites W2046517086 @default.
- W3111249725 cites W2046603954 @default.
- W3111249725 cites W2046942029 @default.
- W3111249725 cites W2047873206 @default.
- W3111249725 cites W2048706422 @default.
- W3111249725 cites W2049222887 @default.
- W3111249725 cites W2050064417 @default.
- W3111249725 cites W2050492409 @default.
- W3111249725 cites W2051058933 @default.
- W3111249725 cites W2051549641 @default.
- W3111249725 cites W2052599602 @default.