FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111272188> ?p ?o ?g. }

• W3111272188 endingPage "68" @default.
• W3111272188 startingPage "57" @default.
• W3111272188 abstract "The kinetics of passive transport of ketoprofen and metformin, as model substances for high and low permeability, respectively, across the artificial membrane under the influence of the pH of donor solution was investigated. There was an upward trend in the apparent permeation coefficient (Papp) of ketoprofen with the decrease in pH to a value close to pKa. At the pH value below pKa the permeation coefficient had lower value, due to the higher retention of ketoprofen in the artificial membrane. Metformin is a low permeable compound, and the highest permeation values were recorded at pH 7.4. Two dissociation constants determine that metformin at physiological pH exists as a hydrophilic cationic molecule, i.e. predominantly in ionized form. At pH values below 2.8, metformin mainly exists in diprotonated form, and it was, thus, very poorly permeable. The highest retention, i.e. affinity of both ketoprofen and metformin to the membrane, was at the lowest pH values, which is explained by different mechanisms. At higher pH values of donor compartment the substances showed significantly less affinity to the membrane. The obtained values of apparent permeation coefficients at studied pH values showed good correlation with the obtained experimental values by other in vitro methods." @default.
• W3111272188 created "2020-12-21" @default.
• W3111272188 creator A5007183810 @default.
• W3111272188 creator A5009300079 @default.
• W3111272188 creator A5010486797 @default.
• W3111272188 creator A5018881418 @default.
• W3111272188 creator A5031162622 @default.
• W3111272188 creator A5046605119 @default.
• W3111272188 creator A5066724259 @default.
• W3111272188 creator A5081516485 @default.
• W3111272188 date "2020-12-08" @default.
• W3111272188 modified "2023-09-25" @default.
• W3111272188 title "In vitro pH dependent passive transport of ketoprofen and metformin" @default.
• W3111272188 cites W115516873 @default.
• W3111272188 cites W1498305210 @default.
• W3111272188 cites W2007052092 @default.
• W3111272188 cites W2019017315 @default.
• W3111272188 cites W2020474316 @default.
• W3111272188 cites W2041427844 @default.
• W3111272188 cites W2060638043 @default.
• W3111272188 cites W2077716285 @default.
• W3111272188 cites W2113381553 @default.
• W3111272188 cites W2117277757 @default.
• W3111272188 cites W2118222538 @default.
• W3111272188 cites W2126079216 @default.
• W3111272188 cites W2154877058 @default.
• W3111272188 cites W2169443538 @default.
• W3111272188 cites W2190902801 @default.
• W3111272188 cites W2471591838 @default.
• W3111272188 cites W2755491718 @default.
• W3111272188 cites W2797612297 @default.
• W3111272188 cites W2924431860 @default.
• W3111272188 cites W4243773020 @default.
• W3111272188 cites W5737657 @default.
• W3111272188 doi "https://doi.org/10.5599/admet.916" @default.
• W3111272188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35299877" @default.
• W3111272188 hasPublicationYear "2020" @default.
• W3111272188 type Work @default.
• W3111272188 sameAs 3111272188 @default.
• W3111272188 citedByCount "1" @default.
• W3111272188 countsByYear W31112721882023 @default.
• W3111272188 crossrefType "journal-article" @default.
• W3111272188 hasAuthorship W3111272188A5007183810 @default.
• W3111272188 hasAuthorship W3111272188A5009300079 @default.
• W3111272188 hasAuthorship W3111272188A5010486797 @default.
• W3111272188 hasAuthorship W3111272188A5018881418 @default.
• W3111272188 hasAuthorship W3111272188A5031162622 @default.
• W3111272188 hasAuthorship W3111272188A5046605119 @default.
• W3111272188 hasAuthorship W3111272188A5066724259 @default.
• W3111272188 hasAuthorship W3111272188A5081516485 @default.
• W3111272188 hasBestOaLocation W31112721883 @default.
• W3111272188 hasConcept C102931765 @default.
• W3111272188 hasConcept C113196181 @default.
• W3111272188 hasConcept C120882062 @default.
• W3111272188 hasConcept C121332964 @default.
• W3111272188 hasConcept C134018914 @default.
• W3111272188 hasConcept C148898269 @default.
• W3111272188 hasConcept C155515750 @default.
• W3111272188 hasConcept C170493617 @default.
• W3111272188 hasConcept C178790620 @default.
• W3111272188 hasConcept C185592680 @default.
• W3111272188 hasConcept C192552737 @default.
• W3111272188 hasConcept C2779306644 @default.
• W3111272188 hasConcept C2780323712 @default.
• W3111272188 hasConcept C2780744026 @default.
• W3111272188 hasConcept C2992270614 @default.
• W3111272188 hasConcept C41625074 @default.
• W3111272188 hasConcept C43617362 @default.
• W3111272188 hasConcept C50670333 @default.
• W3111272188 hasConcept C55493867 @default.
• W3111272188 hasConcept C62520636 @default.
• W3111272188 hasConcept C71924100 @default.
• W3111272188 hasConcept C74998103 @default.
• W3111272188 hasConceptScore W3111272188C102931765 @default.
• W3111272188 hasConceptScore W3111272188C113196181 @default.
• W3111272188 hasConceptScore W3111272188C120882062 @default.
• W3111272188 hasConceptScore W3111272188C121332964 @default.
• W3111272188 hasConceptScore W3111272188C134018914 @default.
• W3111272188 hasConceptScore W3111272188C148898269 @default.
• W3111272188 hasConceptScore W3111272188C155515750 @default.
• W3111272188 hasConceptScore W3111272188C170493617 @default.
• W3111272188 hasConceptScore W3111272188C178790620 @default.
• W3111272188 hasConceptScore W3111272188C185592680 @default.
• W3111272188 hasConceptScore W3111272188C192552737 @default.
• W3111272188 hasConceptScore W3111272188C2779306644 @default.
• W3111272188 hasConceptScore W3111272188C2780323712 @default.
• W3111272188 hasConceptScore W3111272188C2780744026 @default.
• W3111272188 hasConceptScore W3111272188C2992270614 @default.
• W3111272188 hasConceptScore W3111272188C41625074 @default.
• W3111272188 hasConceptScore W3111272188C43617362 @default.
• W3111272188 hasConceptScore W3111272188C50670333 @default.
• W3111272188 hasConceptScore W3111272188C55493867 @default.
• W3111272188 hasConceptScore W3111272188C62520636 @default.
• W3111272188 hasConceptScore W3111272188C71924100 @default.
• W3111272188 hasConceptScore W3111272188C74998103 @default.
• W3111272188 hasIssue "1" @default.
• W3111272188 hasLocation W31112721881 @default.
• W3111272188 hasLocation W31112721882 @default.

• next