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• W3111330916 endingPage "120183" @default.
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• W3111330916 abstract "Lymph node metastases in cancer patients are associated with high aggressiveness, poor prognosis, and short survival time. The chemokine receptor 4 (CXCR4)/stroma derived factor 1α (CXCL12) biological axis plays a critical role in the spread of cancer cells. Designing effective delivery systems that can successfully deliver CXCR4 antagonists to lymph nodes, which are rich in CXCR4-overexpressing cancer cells, for controlling cancer metastasis remain challenging. In this study, we demonstrated that such a challenge may be alleviated by developing nanometer-sized polyethylene glycol-phosphatidylethanolamine (PEG-PE) micelles for the co-delivery of the CXCR4 antagonistic peptide E5 and doxorubicin (M-E5-Dox). This nanomicelle platform enables the preferential accumulation of cargos into lymph nodes and thus can better inhibit cancer metastasis and enhance antitumor efficacy than either free drugs or single drug-loaded micelles in breast cancer-bearing mouse models. Hence, M-E5-Dox is expected to be a potential therapeutic agent that would improve the clinical benefits of breast cancer therapy and treatment of various CXCR4-overexpressing malignancies." @default.
• W3111330916 created "2020-12-21" @default.
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• W3111330916 date "2021-02-01" @default.
• W3111330916 modified "2023-10-16" @default.
• W3111330916 title "Enhanced lymphatic delivery of nanomicelles encapsulating CXCR4-recognizing peptide and doxorubicin for the treatment of breast cancer" @default.
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• W3111330916 doi "https://doi.org/10.1016/j.ijpharm.2020.120183" @default.
• W3111330916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33340596" @default.
• W3111330916 hasPublicationYear "2021" @default.
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