Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111346219> ?p ?o ?g. }
- W3111346219 abstract "Abstract Background Planarians reliably regenerate all body parts after injury, including a fully functional head and central nervous system. But until now, the expression dynamics and functional role of miRNAs and other small RNAs during the process of head regeneration are not well understood. Furthermore, little is known about the evolutionary conservation of the relevant small RNAs pathways, rendering it difficult to assess whether insights from planarians will apply to other taxa. Results In this study, we applied high throughput sequencing to identify miRNAs, tRNA fragments and piRNAs that are dynamically expressed during head regeneration in Dugesia japonica . We further show that knockdown of selected small RNAs, including three novel Dugesia-specific miRNAs, during head regeneration induces severe defects including abnormally small-sized eyes, cyclopia and complete absence of eyes. Conclusions Our findings suggest that a complex pool of small RNAs takes part in the process of head regeneration in Dugesia japonica and provide novel insights into global small RNA expression profiles and expression changes in response to head amputation. Our study reveals the evolutionary conserved role of miR-124 and brings further promising candidate small RNAs into play that might unveil new avenues for inducing restorative programs in non-regenerative organisms via small RNA mimics based therapies." @default.
- W3111346219 created "2020-12-21" @default.
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- W3111346219 date "2020-12-01" @default.
- W3111346219 modified "2023-10-09" @default.
- W3111346219 title "Different classes of small RNAs are essential for head regeneration in the planarian Dugesia japonica" @default.
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- W3111346219 doi "https://doi.org/10.1186/s12864-020-07234-1" @default.
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