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• W3111366633 abstract "Abstract Background Growing primary breast cancers (PT) can initiate local (LR), regional (pLN), and distant metastases (MET). Characteristics of these progressions such as initiation, frequency, growth duration and treatment success describe principles of these processes. They are bottlenecks through which scientific and molecular biological concepts and hypotheses must fit. Methods Population-based data from the Munich Cancer Registry over 4 time periods since 1978 with the most important prognostic factors and an up to date follow-up are analyzed. With 66.818 patients, reliable data are obtained on initiation on METs, growth time und survival even in small subgroups. Together with results of clinical trials on prevention and adjuvant treatment (AT) principles for tumor growth, MET process and AT are derived. Results The median growth periods for PT/ MET/LR/pLN result in 12.5/8.8/5/3.5 years. Even if 30% of METs only appear after 10 years of MET-free time, a delayed initiation or cascade like initiation of METs, e.g. from pLNs cannot be derived from the data. That is an immediate MET initiation principle by PT. The growth rate of the PT can vary by a factor of 10 or more and can be transferred to the MET. Nevertheless, the relation of the growth times PT/MET results in a less varying value of 1.4. Principles of AT are the 50% eradication of 1st and 2ndPTs, the selective and partial eradication of bone and lung METs with successful ATs, which cannot be improved by extending the duration of ATs. These principles reveal, among other things, that there is no rationale for the accepted for long-term endocrine ATs, breast cancer risk by hormone replacement therapies, or cascading initiation of METs. Conclusion A paradigm with ten principles for the MET process and ATs can be derived from real world data and clinical trials. The principles show limits and opportunities for innovation also through alternative interpretations of well-known studies. The outlined MET process should be generalizable to all solid tumors." @default.
• W3111366633 created "2020-12-21" @default.
• W3111366633 creator A5002953983 @default.
• W3111366633 creator A5006720645 @default.
• W3111366633 creator A5015706809 @default.
• W3111366633 creator A5037501879 @default.
• W3111366633 creator A5038858206 @default.
• W3111366633 creator A5050316905 @default.
• W3111366633 date "2020-12-08" @default.
• W3111366633 modified "2023-10-18" @default.
• W3111366633 title "Breast cancer: Emerging principles of metastasis, adjuvant and neoadjuvant treatment from cancer registry data" @default.
• W3111366633 cites W1562190372 @default.
• W3111366633 cites W1701849548 @default.
• W3111366633 cites W1964427281 @default.
• W3111366633 cites W1972049961 @default.
• W3111366633 cites W1972999647 @default.
• W3111366633 cites W1987483992 @default.
• W3111366633 cites W1997378943 @default.
• W3111366633 cites W2007394221 @default.
• W3111366633 cites W2009224696 @default.
• W3111366633 cites W2013956549 @default.
• W3111366633 cites W2027188617 @default.
• W3111366633 cites W2029607498 @default.
• W3111366633 cites W2030451543 @default.
• W3111366633 cites W2037013151 @default.
• W3111366633 cites W2037327192 @default.
• W3111366633 cites W2042619042 @default.
• W3111366633 cites W2050146329 @default.
• W3111366633 cites W2051899593 @default.
• W3111366633 cites W2052467200 @default.
• W3111366633 cites W2055235037 @default.
• W3111366633 cites W2057151160 @default.
• W3111366633 cites W2062978409 @default.
• W3111366633 cites W2067420088 @default.
• W3111366633 cites W2072593460 @default.
• W3111366633 cites W2075894019 @default.
• W3111366633 cites W2078348833 @default.
• W3111366633 cites W2079142824 @default.
• W3111366633 cites W2087268435 @default.
• W3111366633 cites W2089022967 @default.
• W3111366633 cites W2092868756 @default.
• W3111366633 cites W2099067294 @default.
• W3111366633 cites W2100025800 @default.
• W3111366633 cites W2108296770 @default.
• W3111366633 cites W2109278571 @default.
• W3111366633 cites W2111826361 @default.
• W3111366633 cites W2111976640 @default.
• W3111366633 cites W2116910749 @default.
• W3111366633 cites W2117692326 @default.
• W3111366633 cites W2118728607 @default.
• W3111366633 cites W2129353515 @default.
• W3111366633 cites W2133347950 @default.
• W3111366633 cites W2134310407 @default.
• W3111366633 cites W2146006182 @default.
• W3111366633 cites W2147415463 @default.
• W3111366633 cites W2152393981 @default.
• W3111366633 cites W2155090854 @default.
• W3111366633 cites W2158615473 @default.
• W3111366633 cites W2159612972 @default.
• W3111366633 cites W2160216944 @default.
• W3111366633 cites W2161387798 @default.
• W3111366633 cites W2161977537 @default.
• W3111366633 cites W2165200432 @default.
• W3111366633 cites W2165664908 @default.
• W3111366633 cites W2166969772 @default.
• W3111366633 cites W2167378116 @default.
• W3111366633 cites W2169895148 @default.
• W3111366633 cites W2171298396 @default.
• W3111366633 cites W2171538830 @default.
• W3111366633 cites W2179429273 @default.
• W3111366633 cites W2279220517 @default.
• W3111366633 cites W2315243978 @default.
• W3111366633 cites W2467606258 @default.
• W3111366633 cites W2529908594 @default.
• W3111366633 cites W2553863256 @default.
• W3111366633 cites W2574190322 @default.
• W3111366633 cites W2586144993 @default.
• W3111366633 cites W2586407709 @default.
• W3111366633 cites W2588881638 @default.
• W3111366633 cites W2596133050 @default.
• W3111366633 cites W2604957907 @default.
• W3111366633 cites W2606386320 @default.
• W3111366633 cites W2606455449 @default.
• W3111366633 cites W2624443052 @default.
• W3111366633 cites W2731406160 @default.
• W3111366633 cites W2738216606 @default.
• W3111366633 cites W2742282063 @default.
• W3111366633 cites W2742778815 @default.
• W3111366633 cites W2746672093 @default.
• W3111366633 cites W2747520866 @default.
• W3111366633 cites W2754855139 @default.
• W3111366633 cites W2767600184 @default.
• W3111366633 cites W2785301351 @default.
• W3111366633 cites W2785396603 @default.
• W3111366633 cites W2788884935 @default.
• W3111366633 cites W2789838322 @default.
• W3111366633 cites W2891700678 @default.
• W3111366633 cites W2904991649 @default.
• W3111366633 cites W2946317931 @default.
• W3111366633 cites W2965408810 @default.

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