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• W3111410269 endingPage "1062" @default.
• W3111410269 startingPage "1062" @default.
• W3111410269 abstract "Helicobacter pylori is a bacterium that is capable of colonizing a host for many years, often for a lifetime. The survival in the gastric environment is enabled by the production of numerous virulence factors conditioning adhesion to the mucosa surface, acquisition of nutrients, and neutralization of the immune system activity. It is increasingly recognized, however, that the adaptive mechanisms of H. pylori in the stomach may also be linked to the ability of this pathogen to form biofilms. Initially, biofilms produced by H. pylori were strongly associated by scientists with water distribution systems and considered as a survival mechanism outside the host and a source of fecal-oral infections. In the course of the last 20 years, however, this trend has changed and now the most attention is focused on the biomedical aspect of this structure and its potential contribution to the therapeutic difficulties of H. pylori. Taking into account this fact, the aim of the current review is to discuss the phenomenon of H. pylori biofilm formation and present this mechanism as a resultant of the virulence and adaptive responses of H. pylori, including morphological transformation, membrane vesicles secretion, matrix production, efflux pump activity, and intermicrobial communication. These mechanisms will be considered in the context of transcriptomic and proteomic changes in H. pylori biofilms and their modulating effect on the development of this complex structure." @default.
• W3111410269 created "2020-12-21" @default.
• W3111410269 creator A5034613960 @default.
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• W3111410269 creator A5062493397 @default.
• W3111410269 creator A5083952332 @default.
• W3111410269 date "2020-12-18" @default.
• W3111410269 modified "2023-10-03" @default.
• W3111410269 title "Biofilm Formation as a Complex Result of Virulence and Adaptive Responses of Helicobacter pylori" @default.
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