Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111438863> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W3111438863 endingPage "S554" @default.
- W3111438863 startingPage "S554" @default.
- W3111438863 abstract "The prevalence of diagnosed chronic hepatitis C virus (HCV) infection among pregnant women in the Netherlands is 0.26%, yet many cases remain undiagnosed. HCV screening and treatment of pregnant HCV carriers could reduce the burden of disease and limit vertical transmission from mother to child. This study aims to assess the impact of HCV screening and subsequent treatment with new direct-acting antivirals among pregnant women in the Netherlands. An HCV natural history Markov transition state model was developed, to evaluate the cost-effectiveness of HCV screening and treatment. Besides all 179,000 pregnant women in the Netherlands (cohort 1), we modelled three further cohorts: all 79,000 first-time pregnant women (cohort 2), 33,000 pregnant migrant women (cohort 3) and 16,000 first-time pregnant migrant women (cohort 4). Each cohort was analyzed in various scenarios: (i) no intervention, i.e. the current practice, (ii) screen-and-treat, i.e. the most extensive approach involving treatment of all individuals found HCV-positive, and (iii) screen-and-treat/monitor, i.e. a strategy involving treatment of symptomatic patients and follow-up of asymptomatic HCV carriers with subsequent treatment only at progression. For all studied cohorts, comparison between scenarios (ii) and (i) resulted in ICERs varying between €8,343 and €9,182 per QALY gained, with a budget impact varying from €11,283,830 to €34,502,880. For all cohorts, comparison between scenarios (iii) and (i) resulted in ICERs between €1,566 and €2,518 per QALY gained with budget impact varying from €1,668,670 to €6,534,650. For all cohorts, the ICERs involved in potentially unnecessary treatment of asymptomatic HCV carriers varied between €52,432 and €53,641, well above the willingness-to-pay (WTP) threshold of €20,000 per QALY gained. Screening for HCV among all pregnant women in the Netherlands is cost-effective. However, for active screening and treatment, it would be most reasonable to consider smaller risk groups in view of the budget impact." @default.
- W3111438863 created "2020-12-21" @default.
- W3111438863 creator A5007660579 @default.
- W3111438863 creator A5014433950 @default.
- W3111438863 creator A5025153703 @default.
- W3111438863 creator A5035040485 @default.
- W3111438863 creator A5047921978 @default.
- W3111438863 creator A5060651441 @default.
- W3111438863 date "2020-12-01" @default.
- W3111438863 modified "2023-09-29" @default.
- W3111438863 title "PIN55 Cost-Effectiveness of Hepatitis C VIRUS Screening, and Subsequent Monitoring or Treatment Among Pregnant Women in the Netherlands" @default.
- W3111438863 doi "https://doi.org/10.1016/j.jval.2020.08.896" @default.
- W3111438863 hasPublicationYear "2020" @default.
- W3111438863 type Work @default.
- W3111438863 sameAs 3111438863 @default.
- W3111438863 citedByCount "0" @default.
- W3111438863 crossrefType "journal-article" @default.
- W3111438863 hasAuthorship W3111438863A5007660579 @default.
- W3111438863 hasAuthorship W3111438863A5014433950 @default.
- W3111438863 hasAuthorship W3111438863A5025153703 @default.
- W3111438863 hasAuthorship W3111438863A5035040485 @default.
- W3111438863 hasAuthorship W3111438863A5047921978 @default.
- W3111438863 hasAuthorship W3111438863A5060651441 @default.
- W3111438863 hasBestOaLocation W31114388631 @default.
- W3111438863 hasConcept C119599485 @default.
- W3111438863 hasConcept C126322002 @default.
- W3111438863 hasConcept C127413603 @default.
- W3111438863 hasConcept C131872663 @default.
- W3111438863 hasConcept C187212893 @default.
- W3111438863 hasConcept C201903717 @default.
- W3111438863 hasConcept C203014093 @default.
- W3111438863 hasConcept C2522874641 @default.
- W3111438863 hasConcept C2776408679 @default.
- W3111438863 hasConcept C2776455275 @default.
- W3111438863 hasConcept C2777910003 @default.
- W3111438863 hasConcept C2779234561 @default.
- W3111438863 hasConcept C54355233 @default.
- W3111438863 hasConcept C71924100 @default.
- W3111438863 hasConcept C72563966 @default.
- W3111438863 hasConcept C761482 @default.
- W3111438863 hasConcept C86803240 @default.
- W3111438863 hasConceptScore W3111438863C119599485 @default.
- W3111438863 hasConceptScore W3111438863C126322002 @default.
- W3111438863 hasConceptScore W3111438863C127413603 @default.
- W3111438863 hasConceptScore W3111438863C131872663 @default.
- W3111438863 hasConceptScore W3111438863C187212893 @default.
- W3111438863 hasConceptScore W3111438863C201903717 @default.
- W3111438863 hasConceptScore W3111438863C203014093 @default.
- W3111438863 hasConceptScore W3111438863C2522874641 @default.
- W3111438863 hasConceptScore W3111438863C2776408679 @default.
- W3111438863 hasConceptScore W3111438863C2776455275 @default.
- W3111438863 hasConceptScore W3111438863C2777910003 @default.
- W3111438863 hasConceptScore W3111438863C2779234561 @default.
- W3111438863 hasConceptScore W3111438863C54355233 @default.
- W3111438863 hasConceptScore W3111438863C71924100 @default.
- W3111438863 hasConceptScore W3111438863C72563966 @default.
- W3111438863 hasConceptScore W3111438863C761482 @default.
- W3111438863 hasConceptScore W3111438863C86803240 @default.
- W3111438863 hasLocation W31114388631 @default.
- W3111438863 hasOpenAccess W3111438863 @default.
- W3111438863 hasPrimaryLocation W31114388631 @default.
- W3111438863 hasRelatedWork W1977306685 @default.
- W3111438863 hasRelatedWork W2018450738 @default.
- W3111438863 hasRelatedWork W2021929421 @default.
- W3111438863 hasRelatedWork W2181663989 @default.
- W3111438863 hasRelatedWork W2418975291 @default.
- W3111438863 hasRelatedWork W2583295287 @default.
- W3111438863 hasRelatedWork W2965458857 @default.
- W3111438863 hasRelatedWork W3081332639 @default.
- W3111438863 hasRelatedWork W3208192759 @default.
- W3111438863 hasRelatedWork W4200271224 @default.
- W3111438863 hasVolume "23" @default.
- W3111438863 isParatext "false" @default.
- W3111438863 isRetracted "false" @default.
- W3111438863 magId "3111438863" @default.
- W3111438863 workType "article" @default.