Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111454367> ?p ?o ?g. }
- W3111454367 endingPage "16996" @default.
- W3111454367 startingPage "16984" @default.
- W3111454367 abstract "Excessive oxidative stress in cancer cells can induce cancer cell death. Anticancer activity and drug resistance of chemotherapy are closely related to the redox state of tumor cells. Herein, five lipophilic Pt(IV) prodrugs were synthesized on the basis of the most widely used anticancer drug cisplatin, whose anticancer efficacy and drug resistance are closely related to the intracellular redox state. Subsequently, a series of cisplatin-sensitive and drug-resistant cell lines as well as three patient-derived primary ovarian cancer cells have been selected to screen those prodrugs. To verify if the disruption of redox balance can be combined with these Pt(IV) prodrugs, we then synthesized a polymer with a diselenium bond in the main chain for encapsulating the most effective prodrug to form nanoparticles (NP(Se)s). NP(Se)s can efficiently break the redox balance via simultaneously depleting GSH and augmenting ROS, thereby achieving a synergistic effect with cisplatin. In addition, genome-wide analysis via RNA-seq was employed to provide a comprehensive understanding of the changes in transcriptome and the alterations in redox-related pathways in cells treated with NP(Se)s and cisplatin. Thereafter, patient-derived xenograft models of hepatic carcinoma (PDXHCC) and multidrug-resistant lung cancer (PDXMDR) were established to evaluate the therapeutic effect of NP(Se)s, and a significant antitumor effect was achieved on both models with NP(Se)s. Overall, this study provides a promising strategy to break the redox balance for maximizing the efficacy of platinum-based cancer therapy." @default.
- W3111454367 created "2020-12-21" @default.
- W3111454367 creator A5002608004 @default.
- W3111454367 creator A5011411920 @default.
- W3111454367 creator A5014125253 @default.
- W3111454367 creator A5021528065 @default.
- W3111454367 creator A5035969953 @default.
- W3111454367 creator A5039708803 @default.
- W3111454367 creator A5043389551 @default.
- W3111454367 creator A5049166738 @default.
- W3111454367 creator A5050237707 @default.
- W3111454367 creator A5056148571 @default.
- W3111454367 creator A5057416382 @default.
- W3111454367 creator A5057717921 @default.
- W3111454367 creator A5060695809 @default.
- W3111454367 creator A5072480947 @default.
- W3111454367 creator A5078081721 @default.
- W3111454367 creator A5082887195 @default.
- W3111454367 creator A5083189092 @default.
- W3111454367 creator A5086697134 @default.
- W3111454367 creator A5089416136 @default.
- W3111454367 date "2020-12-07" @default.
- W3111454367 modified "2023-10-16" @default.
- W3111454367 title "Breaking the Intracellular Redox Balance with Diselenium Nanoparticles for Maximizing Chemotherapy Efficacy on Patient-Derived Xenograft Models" @default.
- W3111454367 cites W1969101934 @default.
- W3111454367 cites W1969524738 @default.
- W3111454367 cites W1972779889 @default.
- W3111454367 cites W1987604182 @default.
- W3111454367 cites W1999120747 @default.
- W3111454367 cites W1999671588 @default.
- W3111454367 cites W2003110090 @default.
- W3111454367 cites W2008294808 @default.
- W3111454367 cites W2017936372 @default.
- W3111454367 cites W2035134488 @default.
- W3111454367 cites W2054129051 @default.
- W3111454367 cites W2055385681 @default.
- W3111454367 cites W2066864190 @default.
- W3111454367 cites W2101579411 @default.
- W3111454367 cites W2118952409 @default.
- W3111454367 cites W2124141272 @default.
- W3111454367 cites W2138707441 @default.
- W3111454367 cites W2139132031 @default.
- W3111454367 cites W2159515687 @default.
- W3111454367 cites W2162957160 @default.
- W3111454367 cites W2203908584 @default.
- W3111454367 cites W2276371085 @default.
- W3111454367 cites W2277148392 @default.
- W3111454367 cites W2329599594 @default.
- W3111454367 cites W2333282498 @default.
- W3111454367 cites W2417676241 @default.
- W3111454367 cites W2468499096 @default.
- W3111454367 cites W2583207915 @default.
- W3111454367 cites W2783392188 @default.
- W3111454367 cites W2791564057 @default.
- W3111454367 cites W2799938265 @default.
- W3111454367 cites W2808212266 @default.
- W3111454367 cites W2808350668 @default.
- W3111454367 cites W2896262959 @default.
- W3111454367 cites W2898568606 @default.
- W3111454367 cites W2902946041 @default.
- W3111454367 cites W2912335852 @default.
- W3111454367 cites W2912665154 @default.
- W3111454367 cites W2919504086 @default.
- W3111454367 cites W2925016309 @default.
- W3111454367 cites W2937511191 @default.
- W3111454367 cites W2943822791 @default.
- W3111454367 cites W2966094674 @default.
- W3111454367 cites W2969374678 @default.
- W3111454367 cites W2972936715 @default.
- W3111454367 cites W2994679067 @default.
- W3111454367 cites W2995162523 @default.
- W3111454367 cites W3014587976 @default.
- W3111454367 cites W3032914086 @default.
- W3111454367 cites W3085879689 @default.
- W3111454367 cites W4211160926 @default.
- W3111454367 cites W4239546129 @default.
- W3111454367 doi "https://doi.org/10.1021/acsnano.0c06190" @default.
- W3111454367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33283501" @default.
- W3111454367 hasPublicationYear "2020" @default.
- W3111454367 type Work @default.
- W3111454367 sameAs 3111454367 @default.
- W3111454367 citedByCount "84" @default.
- W3111454367 countsByYear W31114543672021 @default.
- W3111454367 countsByYear W31114543672022 @default.
- W3111454367 countsByYear W31114543672023 @default.
- W3111454367 crossrefType "journal-article" @default.
- W3111454367 hasAuthorship W3111454367A5002608004 @default.
- W3111454367 hasAuthorship W3111454367A5011411920 @default.
- W3111454367 hasAuthorship W3111454367A5014125253 @default.
- W3111454367 hasAuthorship W3111454367A5021528065 @default.
- W3111454367 hasAuthorship W3111454367A5035969953 @default.
- W3111454367 hasAuthorship W3111454367A5039708803 @default.
- W3111454367 hasAuthorship W3111454367A5043389551 @default.
- W3111454367 hasAuthorship W3111454367A5049166738 @default.
- W3111454367 hasAuthorship W3111454367A5050237707 @default.
- W3111454367 hasAuthorship W3111454367A5056148571 @default.
- W3111454367 hasAuthorship W3111454367A5057416382 @default.
- W3111454367 hasAuthorship W3111454367A5057717921 @default.