FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111495514> ?p ?o ?g. }

• W3111495514 endingPage "113066" @default.
• W3111495514 startingPage "113066" @default.
• W3111495514 abstract "Major depression disorder (MDD) is one of the most widespread and debilitating psychiatric diseases and may be associated with other mental disorders such as anxiety. Despite advances in neurobiology studies, currently no established mechanism can explain all facets of MDD, and available drugs often show therapeutic delay for clinical effectiveness and response rates in patients are around 50 %. Previous activities of piperazine derivatives on CNS are indicators of its therapeutic potential for treating mental disorders. In this regard, we have previously shown that the piperazine derivative 2,6-di-tert-butyl-4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)phenol (LQFM212) has anxiolytic-like activity which involves serotonergic pathway, nicotinic receptors and BZD-site of GABAA receptor, without cognitive impairments. Herein, was evaluated the potential antidepressant-like effect of LQFM212 on forced swimming test (FST) after a single dose of 54 μmol/kg and after repeated treatment for 15 days in mice. Pretreatment with WAY-100635, PCPA, prazosin, SCH-23390, sulpiride or AMPT reversed the antidepressant-like effect on FST, suggesting that monoaminergic pathway contributes for effects of LQFM212. Furthermore, repeated treatment with LQFM212 increased hippocampal BDNF levels dosed by ELISA kit. In assessment of possible adverse effects, repeated treatment with LQFM212 did not alter the body weight of the animals, glutathione levels in the liver, and serum levels of AST, ALT, urea, and creatinine. Taken together, the results showed that LQFM212 has an antidepressant-like effect that involves monoaminergic pathway and increased BDNF levels. This compound represents promising candidate for prototype of psychoactive drugs for treatment of anxiety and depression disorders since these pathological conditions may exist in comorbidities." @default.
• W3111495514 created "2020-12-21" @default.
• W3111495514 creator A5003052957 @default.
• W3111495514 creator A5003883177 @default.
• W3111495514 creator A5007770033 @default.
• W3111495514 creator A5011463890 @default.
• W3111495514 creator A5020498181 @default.
• W3111495514 creator A5044783142 @default.
• W3111495514 creator A5054572296 @default.
• W3111495514 creator A5066474157 @default.
• W3111495514 creator A5074547471 @default.
• W3111495514 creator A5075209868 @default.
• W3111495514 creator A5080213944 @default.
• W3111495514 date "2021-03-01" @default.
• W3111495514 modified "2023-09-26" @default.
• W3111495514 title "Potential antidepressant-like effect of piperazine derivative LQFM212 in mice: Role of monoaminergic pathway and brain-derived neurotrophic factor" @default.
• W3111495514 cites W1537934849 @default.
• W3111495514 cites W1871684389 @default.
• W3111495514 cites W1974605151 @default.
• W3111495514 cites W1983176528 @default.
• W3111495514 cites W1998613952 @default.
• W3111495514 cites W1998938457 @default.
• W3111495514 cites W2004696348 @default.
• W3111495514 cites W2016100219 @default.
• W3111495514 cites W2024636695 @default.
• W3111495514 cites W2029046909 @default.
• W3111495514 cites W2035086406 @default.
• W3111495514 cites W2037409999 @default.
• W3111495514 cites W2037662525 @default.
• W3111495514 cites W2041849031 @default.
• W3111495514 cites W2043799782 @default.
• W3111495514 cites W2048724816 @default.
• W3111495514 cites W2053472601 @default.
• W3111495514 cites W2054695075 @default.
• W3111495514 cites W2070290419 @default.
• W3111495514 cites W2075635987 @default.
• W3111495514 cites W2075874563 @default.
• W3111495514 cites W2076323540 @default.
• W3111495514 cites W2079842475 @default.
• W3111495514 cites W2080965426 @default.
• W3111495514 cites W2088133214 @default.
• W3111495514 cites W2100027531 @default.
• W3111495514 cites W2108798732 @default.
• W3111495514 cites W2110696099 @default.
• W3111495514 cites W2119660434 @default.
• W3111495514 cites W2132158939 @default.
• W3111495514 cites W2140178312 @default.
• W3111495514 cites W2161341080 @default.
• W3111495514 cites W2195092429 @default.
• W3111495514 cites W2258488890 @default.
• W3111495514 cites W231542518 @default.
• W3111495514 cites W2322790968 @default.
• W3111495514 cites W2327277699 @default.
• W3111495514 cites W2412843828 @default.
• W3111495514 cites W2585744029 @default.
• W3111495514 cites W2607000919 @default.
• W3111495514 cites W2730900010 @default.
• W3111495514 cites W2779920068 @default.
• W3111495514 cites W2801079377 @default.
• W3111495514 cites W2807135302 @default.
• W3111495514 cites W2808053923 @default.
• W3111495514 cites W2839982220 @default.
• W3111495514 cites W2965361613 @default.
• W3111495514 cites W2996052033 @default.
• W3111495514 cites W3004443958 @default.
• W3111495514 cites W4293247451 @default.
• W3111495514 cites W4296336789 @default.
• W3111495514 doi "https://doi.org/10.1016/j.bbr.2020.113066" @default.
• W3111495514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33333109" @default.
• W3111495514 hasPublicationYear "2021" @default.
• W3111495514 type Work @default.
• W3111495514 sameAs 3111495514 @default.
• W3111495514 citedByCount "4" @default.
• W3111495514 countsByYear W31114955142021 @default.
• W3111495514 countsByYear W31114955142022 @default.
• W3111495514 countsByYear W31114955142023 @default.
• W3111495514 crossrefType "journal-article" @default.
• W3111495514 hasAuthorship W3111495514A5003052957 @default.
• W3111495514 hasAuthorship W3111495514A5003883177 @default.
• W3111495514 hasAuthorship W3111495514A5007770033 @default.
• W3111495514 hasAuthorship W3111495514A5011463890 @default.
• W3111495514 hasAuthorship W3111495514A5020498181 @default.
• W3111495514 hasAuthorship W3111495514A5044783142 @default.
• W3111495514 hasAuthorship W3111495514A5054572296 @default.
• W3111495514 hasAuthorship W3111495514A5066474157 @default.
• W3111495514 hasAuthorship W3111495514A5074547471 @default.
• W3111495514 hasAuthorship W3111495514A5075209868 @default.
• W3111495514 hasAuthorship W3111495514A5080213944 @default.
• W3111495514 hasConcept C126322002 @default.
• W3111495514 hasConcept C136569192 @default.
• W3111495514 hasConcept C15744967 @default.
• W3111495514 hasConcept C170493617 @default.
• W3111495514 hasConcept C2775864247 @default.
• W3111495514 hasConcept C2779177272 @default.
• W3111495514 hasConcept C2781161787 @default.
• W3111495514 hasConcept C37000724 @default.
• W3111495514 hasConcept C42251903 @default.
• W3111495514 hasConcept C71924100 @default.

• next