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• W3111547887 abstract "Activation of the nerve growth factor (NGF) signaling pathway is a potential method of treatment for retinal ganglion cell (RGC) loss due to traumatic optic neuropathy (TON). The present study aimed to explore the biological effects of injecting Astragalus membranaceus (A. mem) on RGCs in an experimental TON model. Adult male Wistar rats were randomly divided into three groups: sham-operated (SL), model (ML), and A. mem injection (AL). The left eyes of the rats were considered the experimental eyes, and the right eyes served as the controls. AL rats received daily intraperitoneal injections of A. mem (3 mL/kg), whereas ML and SL rats were administered the same volume of normal saline. The TON rat model was induced by optic nerve (ON) transverse quantitative traction. After two-week administration, the number of RGCs was determined using retrograde labeling with Fluoro-Gold. The protein levels of NGF, tyrosine kinase receptor A (TrkA), c-Jun N-terminal protein kinase (JNK), JNK phosphorylation (p-JNK), and nuclear factor kappa-B (NF-κB) were assessed using western blotting. The levels of p75 neurotrophin receptor (p75NTR) and NF-κB DNA binding were examined using real-time PCR and an electrophoretic mobility shift assay. In addition, the concentrations of JNK and p-JNK were assessed using an enzyme-linked immunosorbent assay. Results. The number of RGCs in ML was found to be significantly decreased <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.01</mn> </mrow> </mfenced> </math> relative to both AL and SL, together with the downregulation of NGF <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.01</mn> </mrow> </mfenced> </math> , TrkA <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </mrow> </mfenced> </math> , and NF-κB <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.01</mn> </mrow> </mfenced> </math> ; upregulation of p75NTR mRNA <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.01</mn> </mrow> </mfenced> </math> ; and increased protein levels of JNK <math xmlns=http://www.w3.org/1998/Math/MathML id=M6> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </mrow> </mfenced> </math> and p-JNK <math xmlns=http://www.w3.org/1998/Math/MathML id=M7> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </mrow> </mfenced> </math> . Treatment using A. mem injection significantly preserved the density of RGCs in rats with experimental TON and markedly upregulated the proteins of NGF <math xmlns=http://www.w3.org/1998/Math/MathML id=M8> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.01</mn> </mrow> </mfenced> </math> , TrkA <math xmlns=http://www.w3.org/1998/Math/MathML id=M9> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </mrow> </mfenced> </math> , and NF-κB <math xmlns=http://www.w3.org/1998/Math/MathML id=M10> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.01</mn> </mrow> </mfenced> </math> and downregulated the mRNA level of p75NTR <math xmlns=http://www.w3.org/1998/Math/MathML id=M11> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.01</mn> </mrow> </mfenced> </math> , as well as the proteins of JNK <math xmlns=http://www.w3.org/1998/Math/MathML id=M12> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </mrow> </mfenced> </math> and p-JNK <math xmlns=http://www.w3.org/1998/Math/MathML id=M13> <mfenced open=( close=) separators=|> <mrow> <mi>P</mi> <mo><</mo> <mn>0.01</mn> </mrow> </mfenced> </math> . Thus, A. mem injection could reduce RGC death in TON induced by ON transverse quantitative traction by stimulating the NGF signaling pathway." @default.
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• W3111547887 date "2020-12-18" @default.
• W3111547887 modified "2023-10-14" @default.
• W3111547887 title "Astragalus membranaceus Injection Protects Retinal Ganglion Cells by Regulating the Nerve Growth Factor Signaling Pathway in Experimental Rat Traumatic Optic Neuropathy" @default.
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• W3111547887 doi "https://doi.org/10.1155/2020/2429843" @default.
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