FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111551568> ?p ?o ?g. }

• W3111551568 endingPage "S206" @default.
• W3111551568 startingPage "S205" @default.
• W3111551568 abstract "Context Acute leukemia is an (epi)genetically heterogeneous disease. The intensity of treatment is currently guided by cytogenetic and molecular genetic risk classifications; however, these incompletely predict outcomes, requiring additional information for more accurate predictions. Objective We aimed to identify potential prognostic implications of epigenetic modification of histone proteins in relation to driver mutations in chromatin, splicing and transcriptional regulators in adult-onset acute lymphoblastic (ALL) and myeloid leukemia (AML). Design Bone marrow (BM) and peripheral blood (PB) samples were collected from 114 newly diagnosed B-cell ALL, 14 T-cell ALL, and 241 AML patients who were admitted at the MD Anderson Cancer Center (MDACC) between September 1991 and March 2007. Proteomic profiling was performed using reverse phase protein array and additional mutational analysis was performed on 65 AML BM aspirates. Setting H3K4Me2, H3K4Me3 and H3K27Me3 levels were evaluated along with the expression of 227 other protein antibodies at time of diagnosis. Patients or other participants Patient's ages ranged from 16 to 81 years (median=40±16) in ALL and from 17 to 87 years (median=64±16) in AML. Interventions Patients were treated according to standard MDACC treatment protocols. Main outcome measures Overall survival was considered as the primary study outcome. Results H3K4Me2, H3K4Me3 and H3K27Me3 were significantly higher in AML than in ALL. In AML, greater loss of H3K27Me3 was associated with increased proliferative potential and shorter overall survival in the whole patient population (HR=0.64, 95%CI=0.47-0.87, p=0.004) and in subsets, e.g. cytogenetically normal AML (HR=0.62, 95%CI=0.40-0.97, p=0.03) and IDH1 mutated patients (HR=0.21, 95%CI=0.062-0.72, p=0.009). H3K27Me3 was lower in ASXL1, BCOR, U2AF1 and SRSF2 mutated subgroups (p Conclusions Proteomic profiling of histone modifications has clinical implications in acute leukemia and support the idea that epigenetic patterns contribute to a more accurate picture of the leukemic state and complement cytogenetic and molecular genetic subgrouping. H3K27Me3 measurement might be a suitable method to improve acute leukemia outcome prediction and subsequent treatment intensity stratification in selected subgroups." @default.
• W3111551568 created "2020-12-21" @default.
• W3111551568 creator A5000883612 @default.
• W3111551568 creator A5016607292 @default.
• W3111551568 creator A5049385583 @default.
• W3111551568 creator A5052254566 @default.
• W3111551568 creator A5061298404 @default.
• W3111551568 creator A5067486820 @default.
• W3111551568 creator A5089859116 @default.
• W3111551568 creator A5091758573 @default.
• W3111551568 date "2020-09-01" @default.
• W3111551568 modified "2023-09-27" @default.
• W3111551568 title "AML-343: Loss of H3K27 Methylation Identifies Poor Outcomes in Adult-Onset Acute Lymphoblastic and Myeloid Leukemia" @default.
• W3111551568 doi "https://doi.org/10.1016/s2152-2650(20)30761-8" @default.
• W3111551568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7832620" @default.
• W3111551568 hasPublicationYear "2020" @default.
• W3111551568 type Work @default.
• W3111551568 sameAs 3111551568 @default.
• W3111551568 citedByCount "0" @default.
• W3111551568 crossrefType "journal-article" @default.
• W3111551568 hasAuthorship W3111551568A5000883612 @default.
• W3111551568 hasAuthorship W3111551568A5016607292 @default.
• W3111551568 hasAuthorship W3111551568A5049385583 @default.
• W3111551568 hasAuthorship W3111551568A5052254566 @default.
• W3111551568 hasAuthorship W3111551568A5061298404 @default.
• W3111551568 hasAuthorship W3111551568A5067486820 @default.
• W3111551568 hasAuthorship W3111551568A5089859116 @default.
• W3111551568 hasAuthorship W3111551568A5091758573 @default.
• W3111551568 hasBestOaLocation W31115515681 @default.
• W3111551568 hasConcept C104317684 @default.
• W3111551568 hasConcept C126322002 @default.
• W3111551568 hasConcept C143998085 @default.
• W3111551568 hasConcept C2778461978 @default.
• W3111551568 hasConcept C2778729363 @default.
• W3111551568 hasConcept C2779282312 @default.
• W3111551568 hasConcept C2909962599 @default.
• W3111551568 hasConcept C33288867 @default.
• W3111551568 hasConcept C54355233 @default.
• W3111551568 hasConcept C71924100 @default.
• W3111551568 hasConcept C86803240 @default.
• W3111551568 hasConceptScore W3111551568C104317684 @default.
• W3111551568 hasConceptScore W3111551568C126322002 @default.
• W3111551568 hasConceptScore W3111551568C143998085 @default.
• W3111551568 hasConceptScore W3111551568C2778461978 @default.
• W3111551568 hasConceptScore W3111551568C2778729363 @default.
• W3111551568 hasConceptScore W3111551568C2779282312 @default.
• W3111551568 hasConceptScore W3111551568C2909962599 @default.
• W3111551568 hasConceptScore W3111551568C33288867 @default.
• W3111551568 hasConceptScore W3111551568C54355233 @default.
• W3111551568 hasConceptScore W3111551568C71924100 @default.
• W3111551568 hasConceptScore W3111551568C86803240 @default.
• W3111551568 hasLocation W31115515681 @default.
• W3111551568 hasLocation W31115515682 @default.
• W3111551568 hasOpenAccess W3111551568 @default.
• W3111551568 hasPrimaryLocation W31115515681 @default.
• W3111551568 hasRelatedWork W11815449 @default.
• W3111551568 hasRelatedWork W2072207948 @default.
• W3111551568 hasRelatedWork W2113169665 @default.
• W3111551568 hasRelatedWork W2128510941 @default.
• W3111551568 hasRelatedWork W2311910815 @default.
• W3111551568 hasRelatedWork W2355933270 @default.
• W3111551568 hasRelatedWork W2407161884 @default.
• W3111551568 hasRelatedWork W2410889947 @default.
• W3111551568 hasRelatedWork W2413931914 @default.
• W3111551568 hasRelatedWork W4322706357 @default.
• W3111551568 hasVolume "20" @default.
• W3111551568 isParatext "false" @default.
• W3111551568 isRetracted "false" @default.
• W3111551568 magId "3111551568" @default.
• W3111551568 workType "article" @default.