Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111564900> ?p ?o ?g. }
- W3111564900 abstract "Intraoperative tissue analysis is critical to guide surgical procedures and improve patient outcomes. Here, we describe the clinical translation and intraoperative use of the MasSpec Pen technology for direct molecular analysis of in vivo and freshly excised tissues in the operating room. In this study, the MasSpec Pen was used by surgeons and surgical staff during 100 surgeries over a 12-month period, allowing rapid detection of rich mass spectral profiles from 715 in vivo and ex vivo analyses performed on thyroid, parathyroid, lymph node, breast, pancreatic, and bile duct tissues during parathyroidectomies, thyroidectomies, breast, and pancreatic neoplasia surgeries. The MasSpec Pen enabled gentle extraction and sensitive detection of various molecular species including small metabolites and lipids using a droplet of sterile water without causing apparent tissue damage. Notably, effective molecular analysis was achieved while no limitations to sequential histologic tissue analysis were identified and no device-related complications were reported for any of the patients. Collectively, this study shows that the MasSpec Pen system can be successfully incorporated into the operating room, allowing direct detection of rich molecular profiles from tissues with a seconds-long turnaround time that could be inform surgical and clinical decisions without disrupting tissue analysis workflows." @default.
- W3111564900 created "2020-12-21" @default.
- W3111564900 creator A5007418158 @default.
- W3111564900 creator A5009850000 @default.
- W3111564900 creator A5012398275 @default.
- W3111564900 creator A5012633667 @default.
- W3111564900 creator A5020249051 @default.
- W3111564900 creator A5028152267 @default.
- W3111564900 creator A5028176271 @default.
- W3111564900 creator A5031346687 @default.
- W3111564900 creator A5031616957 @default.
- W3111564900 creator A5035379009 @default.
- W3111564900 creator A5040056111 @default.
- W3111564900 creator A5041293743 @default.
- W3111564900 creator A5050694233 @default.
- W3111564900 creator A5051765654 @default.
- W3111564900 creator A5056908081 @default.
- W3111564900 creator A5061279376 @default.
- W3111564900 creator A5063781071 @default.
- W3111564900 creator A5066401460 @default.
- W3111564900 creator A5068913794 @default.
- W3111564900 creator A5070674364 @default.
- W3111564900 creator A5073097924 @default.
- W3111564900 creator A5075678067 @default.
- W3111564900 creator A5077160653 @default.
- W3111564900 creator A5081981510 @default.
- W3111564900 date "2020-12-16" @default.
- W3111564900 modified "2023-10-18" @default.
- W3111564900 title "Direct Molecular Analysis of In Vivo and Freshly Excised Tissues in Human Surgeries with the MasSpec Pen Technology" @default.
- W3111564900 cites W1936066510 @default.
- W3111564900 cites W1984282924 @default.
- W3111564900 cites W1988928743 @default.
- W3111564900 cites W1989632492 @default.
- W3111564900 cites W1996311090 @default.
- W3111564900 cites W2012306989 @default.
- W3111564900 cites W2024931221 @default.
- W3111564900 cites W2031519765 @default.
- W3111564900 cites W2050736143 @default.
- W3111564900 cites W2051775822 @default.
- W3111564900 cites W2074130447 @default.
- W3111564900 cites W2101494642 @default.
- W3111564900 cites W2111014842 @default.
- W3111564900 cites W2116731262 @default.
- W3111564900 cites W2125372543 @default.
- W3111564900 cites W2130283850 @default.
- W3111564900 cites W2137871970 @default.
- W3111564900 cites W2139939613 @default.
- W3111564900 cites W2153076843 @default.
- W3111564900 cites W2155633629 @default.
- W3111564900 cites W2164338148 @default.
- W3111564900 cites W2172083191 @default.
- W3111564900 cites W2240084039 @default.
- W3111564900 cites W2333701619 @default.
- W3111564900 cites W2400607299 @default.
- W3111564900 cites W2492146416 @default.
- W3111564900 cites W2494122440 @default.
- W3111564900 cites W2514561022 @default.
- W3111564900 cites W2587305359 @default.
- W3111564900 cites W2590296196 @default.
- W3111564900 cites W2598641350 @default.
- W3111564900 cites W2626112488 @default.
- W3111564900 cites W2739277344 @default.
- W3111564900 cites W2753124759 @default.
- W3111564900 cites W2798093457 @default.
- W3111564900 cites W2885338802 @default.
- W3111564900 cites W2889270477 @default.
- W3111564900 cites W2889551460 @default.
- W3111564900 cites W2912733343 @default.
- W3111564900 cites W2924881066 @default.
- W3111564900 cites W2925641592 @default.
- W3111564900 cites W2979685247 @default.
- W3111564900 cites W2982503462 @default.
- W3111564900 cites W3046471052 @default.
- W3111564900 doi "https://doi.org/10.1101/2020.12.14.20248101" @default.
- W3111564900 hasPublicationYear "2020" @default.
- W3111564900 type Work @default.
- W3111564900 sameAs 3111564900 @default.
- W3111564900 citedByCount "4" @default.
- W3111564900 countsByYear W31115649002021 @default.
- W3111564900 countsByYear W31115649002022 @default.
- W3111564900 crossrefType "posted-content" @default.
- W3111564900 hasAuthorship W3111564900A5007418158 @default.
- W3111564900 hasAuthorship W3111564900A5009850000 @default.
- W3111564900 hasAuthorship W3111564900A5012398275 @default.
- W3111564900 hasAuthorship W3111564900A5012633667 @default.
- W3111564900 hasAuthorship W3111564900A5020249051 @default.
- W3111564900 hasAuthorship W3111564900A5028152267 @default.
- W3111564900 hasAuthorship W3111564900A5028176271 @default.
- W3111564900 hasAuthorship W3111564900A5031346687 @default.
- W3111564900 hasAuthorship W3111564900A5031616957 @default.
- W3111564900 hasAuthorship W3111564900A5035379009 @default.
- W3111564900 hasAuthorship W3111564900A5040056111 @default.
- W3111564900 hasAuthorship W3111564900A5041293743 @default.
- W3111564900 hasAuthorship W3111564900A5050694233 @default.
- W3111564900 hasAuthorship W3111564900A5051765654 @default.
- W3111564900 hasAuthorship W3111564900A5056908081 @default.
- W3111564900 hasAuthorship W3111564900A5061279376 @default.
- W3111564900 hasAuthorship W3111564900A5063781071 @default.
- W3111564900 hasAuthorship W3111564900A5066401460 @default.
- W3111564900 hasAuthorship W3111564900A5068913794 @default.