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• W3111569563 endingPage "9505" @default.
• W3111569563 startingPage "9505" @default.
• W3111569563 abstract "While the most common manifestations associated with rheumatoid arthritis (RA) are synovial damage and inflammation, the systemic effects of this autoimmune disorder are life-threatening, and are prevalent in 0.5–1% of the population, mainly associated with cardiovascular disorders (CVDs). Such effects have been instigated by an altered lipid profile in RA patients, which has been reported to correlate with CV risks. Altered lipid paradox is related to inflammatory burden in RA patients. The review highlights general lipid pathways (exogenous and endogenous), along with the changes in different forms of lipids and lipoproteins in RA conditions, which further contribute to elevated risks of CVDs like ischemic heart disease, atherosclerosis, myocardial infarction etc. The authors provide a deep insight on altered levels of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TGs) in RA patients and their consequence on the cardiovascular health of the patient. This is followed by a detailed description of the impact of anti-rheumatoid therapy on the lipid profile in RA patients, comprising DMARDs, corticosteroids, anti-TNF agents, anti-IL-6 agents, JAK inhibitors and statins. Furthermore, this review elaborates on the prospects to be considered to optimize future investigation on management of RA and treatment therapies targeting altered lipid paradigms in patients." @default.
• W3111569563 created "2020-12-21" @default.
• W3111569563 creator A5030945412 @default.
• W3111569563 creator A5031120419 @default.
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• W3111569563 creator A5053776730 @default.
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• W3111569563 creator A5064077982 @default.
• W3111569563 creator A5069616412 @default.
• W3111569563 creator A5088364476 @default.
• W3111569563 date "2020-12-14" @default.
• W3111569563 modified "2023-10-10" @default.
• W3111569563 title "The Lipid Paradox as a Metabolic Checkpoint and Its Therapeutic Significance in Ameliorating the Associated Cardiovascular Risks in Rheumatoid Arthritis Patients" @default.
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