Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111572425> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3111572425 endingPage "347" @default.
- W3111572425 startingPage "341" @default.
- W3111572425 abstract "Purpose The main goal of the research was to determine whether commercially available common dietary phytochemical supplements (curcumin, andrographolide, and d-limonene) have radiomodulatory effects on p53-competent human colonic epithelial cells.Methods Clonogenic survival assays were used to characterize effects of the phytochemicals on cultured colonic epithelial cells (HCT116 p53+/+) in direct irradiation or upon receipt of irradiated-cell conditioned media (for bystander effects). In direct irradiation, feeding regimen experiments included compound administration pre- and post-irradiation, which was used as a basis to define effects as radioprotective and radiomitigative, respectively. In the bystander effect experiments, either donor or recipient cell cultures were fed with the phytochemicals and bystander-induced clonogenic cell death was quantitatively evaluated. Dose challenge was in the range of 0.5 − 5 Gy using the gamma source (Cs-137).Results Curcumin, andrographolide, and d-limonene appeared to not exhibit radioprotective and radiomitigative properties in HCT116 p53+/+ cells. D-limonene was found to induce radiosensitization in post-irradiation administration. All three compounds appeared not to modulate the radiation-induced bystander signal production and response in HCT116 p53+/+ cells.Conclusions Curcumin, andrographolide, and d-limonene are known to have many chemoprotective benefits. This work shows that they, however, did not protect colonic epithelial HCT116 p53+/+ cells from radiation killing. As HCT116 p53+/+ cells are tumourigenic in nature, this finding implies that these three dietary compounds would not reduce the killing efficacy of radiation in gastrointestinal tumorigenesis. The post-irradiation radiosensitizing effect of d-limonene was an intriguing observation worth further investigation." @default.
- W3111572425 created "2020-12-21" @default.
- W3111572425 creator A5001011450 @default.
- W3111572425 creator A5033238464 @default.
- W3111572425 creator A5048866889 @default.
- W3111572425 creator A5064734194 @default.
- W3111572425 creator A5071692151 @default.
- W3111572425 date "2021-01-07" @default.
- W3111572425 modified "2023-09-26" @default.
- W3111572425 title "Influence of common dietary supplements (curcumin, andrographolide, and d-limonene) on the radiobiological responses of p53-competent colonic cancer epithelial cells" @default.
- W3111572425 cites W1972685575 @default.
- W3111572425 cites W1977920395 @default.
- W3111572425 cites W1980250725 @default.
- W3111572425 cites W1991350784 @default.
- W3111572425 cites W2005766554 @default.
- W3111572425 cites W2008484243 @default.
- W3111572425 cites W2047182167 @default.
- W3111572425 cites W2057461325 @default.
- W3111572425 cites W2061342795 @default.
- W3111572425 cites W2092803489 @default.
- W3111572425 cites W2101331356 @default.
- W3111572425 cites W2108604795 @default.
- W3111572425 cites W2109126550 @default.
- W3111572425 cites W2129686894 @default.
- W3111572425 cites W2149724396 @default.
- W3111572425 cites W2167894711 @default.
- W3111572425 cites W2781013802 @default.
- W3111572425 cites W2938125118 @default.
- W3111572425 cites W2943118971 @default.
- W3111572425 cites W2969991333 @default.
- W3111572425 doi "https://doi.org/10.1080/09553002.2021.1864499" @default.
- W3111572425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33320772" @default.
- W3111572425 hasPublicationYear "2021" @default.
- W3111572425 type Work @default.
- W3111572425 sameAs 3111572425 @default.
- W3111572425 citedByCount "3" @default.
- W3111572425 countsByYear W31115724252021 @default.
- W3111572425 countsByYear W31115724252023 @default.
- W3111572425 crossrefType "journal-article" @default.
- W3111572425 hasAuthorship W3111572425A5001011450 @default.
- W3111572425 hasAuthorship W3111572425A5033238464 @default.
- W3111572425 hasAuthorship W3111572425A5048866889 @default.
- W3111572425 hasAuthorship W3111572425A5064734194 @default.
- W3111572425 hasAuthorship W3111572425A5071692151 @default.
- W3111572425 hasConcept C104317684 @default.
- W3111572425 hasConcept C117262875 @default.
- W3111572425 hasConcept C1491633281 @default.
- W3111572425 hasConcept C185592680 @default.
- W3111572425 hasConcept C19106626 @default.
- W3111572425 hasConcept C203014093 @default.
- W3111572425 hasConcept C2776134268 @default.
- W3111572425 hasConcept C2777278459 @default.
- W3111572425 hasConcept C2778250585 @default.
- W3111572425 hasConcept C2781357234 @default.
- W3111572425 hasConcept C31903555 @default.
- W3111572425 hasConcept C502942594 @default.
- W3111572425 hasConcept C55493867 @default.
- W3111572425 hasConcept C555283112 @default.
- W3111572425 hasConcept C71924100 @default.
- W3111572425 hasConcept C98274493 @default.
- W3111572425 hasConceptScore W3111572425C104317684 @default.
- W3111572425 hasConceptScore W3111572425C117262875 @default.
- W3111572425 hasConceptScore W3111572425C1491633281 @default.
- W3111572425 hasConceptScore W3111572425C185592680 @default.
- W3111572425 hasConceptScore W3111572425C19106626 @default.
- W3111572425 hasConceptScore W3111572425C203014093 @default.
- W3111572425 hasConceptScore W3111572425C2776134268 @default.
- W3111572425 hasConceptScore W3111572425C2777278459 @default.
- W3111572425 hasConceptScore W3111572425C2778250585 @default.
- W3111572425 hasConceptScore W3111572425C2781357234 @default.
- W3111572425 hasConceptScore W3111572425C31903555 @default.
- W3111572425 hasConceptScore W3111572425C502942594 @default.
- W3111572425 hasConceptScore W3111572425C55493867 @default.
- W3111572425 hasConceptScore W3111572425C555283112 @default.
- W3111572425 hasConceptScore W3111572425C71924100 @default.
- W3111572425 hasConceptScore W3111572425C98274493 @default.
- W3111572425 hasFunder F4320320994 @default.
- W3111572425 hasFunder F4320321492 @default.
- W3111572425 hasFunder F4320334593 @default.
- W3111572425 hasIssue "3" @default.
- W3111572425 hasLocation W31115724251 @default.
- W3111572425 hasOpenAccess W3111572425 @default.
- W3111572425 hasPrimaryLocation W31115724251 @default.
- W3111572425 hasRelatedWork W2053663898 @default.
- W3111572425 hasRelatedWork W2102856042 @default.
- W3111572425 hasRelatedWork W2128625175 @default.
- W3111572425 hasRelatedWork W2335782746 @default.
- W3111572425 hasRelatedWork W2367544145 @default.
- W3111572425 hasRelatedWork W2885029506 @default.
- W3111572425 hasRelatedWork W2944380828 @default.
- W3111572425 hasRelatedWork W2953014029 @default.
- W3111572425 hasRelatedWork W3009705489 @default.
- W3111572425 hasRelatedWork W3111572425 @default.
- W3111572425 hasVolume "97" @default.
- W3111572425 isParatext "false" @default.
- W3111572425 isRetracted "false" @default.
- W3111572425 magId "3111572425" @default.
- W3111572425 workType "article" @default.