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• W3111581569 abstract "Abstract Identification and development of effective drugs active against SARS-CoV-2 are urgently needed. Here, we report on the anti-SARS-CoV-2 activity of MEDS433, a novel inhibitor of human dihydroorotate dehydrogenase (hDHODH), a key cellular enzyme of the de novo pyrimidines biosynthesis. MEDS433 inhibits in vitro virus replication in the low nanomolar range, and through a mechanism that stems from its ability to block hDHODH activity. MEDS433 thus represents an attractive candidate to develop novel anti-SARS-CoV-2 agents." @default.
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• W3111581569 date "2020-12-07" @default.
• W3111581569 modified "2023-10-16" @default.
• W3111581569 title "The new generation hDHODH inhibitor MEDS433 hinders the<i>in vitro</i>replication of SARS-CoV-2" @default.
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• W3111581569 doi "https://doi.org/10.1101/2020.12.06.412759" @default.
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