FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111594991> ?p ?o ?g. }

• W3111594991 endingPage "11" @default.
• W3111594991 startingPage "1" @default.
• W3111594991 abstract "Despite numerous reports that ambient particulate matter is a key determinant for human health, toxicity data produced based on physicochemical properties of particulate matters is very lack, suggesting lack of scientific evidence for regulation. In this study, we sampled inhalable particulate matters (PM10) in northern Seoul, Korea. PM10 showed atypical- and fiber-type particles with the average size and the surface charge of 1,598.1 ± 128.7 nm and −27.5 ± 2.8, respectively, and various toxic elements were detected in the water extract. On day 90 after the first pulmonary exposure, total cell number dose-dependently increased in the lungs of both sexes of mice. PM10 induced Th1-dominant immune response with pathological changes in both sexes of mice. Meanwhile, composition of total cells and expression of proteins which functions in cell-to-cell communication showed different trends between sexes. Following, male and female mice were mated to identify effects of PM10 to the next generation. PM10 remained in the lung of dams until day 21 after birth, and the levels of IgA and IgE increased in the blood of dams exposed to the maximum dose compared to control. In addition, the interval between births of fetuses, the number of offspring, the neonatal survival rate (day 4 after birth) and the sex ratio seemed to be affected at the maximum dose, and particularly, all offspring from one dam were stillborn. In addition, expression of HIF-1α protein increased in the lung tissue of dams exposed to PM10, and level of hypoxia-related proteins was notably enhanced in PM10-exposed bronchial epithelial cells compared to control. Taken together, we suggest that inhaled PM10 may induce Th1-shifting immune response in the lung, and that it may affect reproduction (fetus development) by causing lung hypoxia. Additionally, we propose that further study is needed to identify particle-size-dependent effects on development of the next generation." @default.
• W3111594991 created "2020-12-21" @default.
• W3111594991 creator A5016492244 @default.
• W3111594991 creator A5016978421 @default.
• W3111594991 creator A5021420347 @default.
• W3111594991 creator A5026337966 @default.
• W3111594991 creator A5047881617 @default.
• W3111594991 creator A5060294522 @default.
• W3111594991 creator A5067757304 @default.
• W3111594991 creator A5068194878 @default.
• W3111594991 creator A5087986309 @default.
• W3111594991 creator A5090254873 @default.
• W3111594991 date "2021-03-01" @default.
• W3111594991 modified "2023-09-30" @default.
• W3111594991 title "Effect of PM10 on pulmonary immune response and fetus development" @default.
• W3111594991 cites W1794617724 @default.
• W3111594991 cites W1980460227 @default.
• W3111594991 cites W1980812873 @default.
• W3111594991 cites W1989427798 @default.
• W3111594991 cites W1993749655 @default.
• W3111594991 cites W2006359896 @default.
• W3111594991 cites W2007919022 @default.
• W3111594991 cites W2015047621 @default.
• W3111594991 cites W2017872607 @default.
• W3111594991 cites W2020173513 @default.
• W3111594991 cites W2028268294 @default.
• W3111594991 cites W2041087647 @default.
• W3111594991 cites W2046889582 @default.
• W3111594991 cites W2056566791 @default.
• W3111594991 cites W2065841670 @default.
• W3111594991 cites W2071611894 @default.
• W3111594991 cites W2076184158 @default.
• W3111594991 cites W2077029034 @default.
• W3111594991 cites W2088967001 @default.
• W3111594991 cites W2098565706 @default.
• W3111594991 cites W2107904415 @default.
• W3111594991 cites W2122314640 @default.
• W3111594991 cites W2124130781 @default.
• W3111594991 cites W2151693351 @default.
• W3111594991 cites W2162809912 @default.
• W3111594991 cites W2163962028 @default.
• W3111594991 cites W2171938848 @default.
• W3111594991 cites W2172173459 @default.
• W3111594991 cites W2178650249 @default.
• W3111594991 cites W2266050978 @default.
• W3111594991 cites W2287592426 @default.
• W3111594991 cites W2299817172 @default.
• W3111594991 cites W2345672003 @default.
• W3111594991 cites W2513644890 @default.
• W3111594991 cites W2519458213 @default.
• W3111594991 cites W2533375210 @default.
• W3111594991 cites W2536925656 @default.
• W3111594991 cites W2588566947 @default.
• W3111594991 cites W2590407211 @default.
• W3111594991 cites W2593030401 @default.
• W3111594991 cites W2607820614 @default.
• W3111594991 cites W2617052964 @default.
• W3111594991 cites W2743009057 @default.
• W3111594991 cites W2763043917 @default.
• W3111594991 cites W2767388944 @default.
• W3111594991 cites W2786512781 @default.
• W3111594991 cites W2789926219 @default.
• W3111594991 cites W2792326835 @default.
• W3111594991 cites W2792378981 @default.
• W3111594991 cites W2794888518 @default.
• W3111594991 cites W2801883850 @default.
• W3111594991 cites W2805724135 @default.
• W3111594991 cites W2898437381 @default.
• W3111594991 cites W2899477564 @default.
• W3111594991 cites W2901058926 @default.
• W3111594991 cites W2901877624 @default.
• W3111594991 cites W2966724896 @default.
• W3111594991 cites W2974156380 @default.
• W3111594991 cites W2976719312 @default.
• W3111594991 cites W2981716030 @default.
• W3111594991 cites W2990342974 @default.
• W3111594991 cites W2998335475 @default.
• W3111594991 cites W3002026331 @default.
• W3111594991 cites W3015282886 @default.
• W3111594991 cites W3035725192 @default.
• W3111594991 cites W3038225380 @default.
• W3111594991 cites W4249271231 @default.
• W3111594991 cites W2016567979 @default.
• W3111594991 doi "https://doi.org/10.1016/j.toxlet.2020.11.024" @default.
• W3111594991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33301788" @default.
• W3111594991 hasPublicationYear "2021" @default.
• W3111594991 type Work @default.
• W3111594991 sameAs 3111594991 @default.
• W3111594991 citedByCount "9" @default.
• W3111594991 countsByYear W31115949912021 @default.
• W3111594991 countsByYear W31115949912022 @default.
• W3111594991 countsByYear W31115949912023 @default.
• W3111594991 crossrefType "journal-article" @default.
• W3111594991 hasAuthorship W3111594991A5016492244 @default.
• W3111594991 hasAuthorship W3111594991A5016978421 @default.
• W3111594991 hasAuthorship W3111594991A5021420347 @default.
• W3111594991 hasAuthorship W3111594991A5026337966 @default.
• W3111594991 hasAuthorship W3111594991A5047881617 @default.

• next