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- W3111595544 endingPage "107791" @default.
- W3111595544 startingPage "107791" @default.
- W3111595544 abstract "Liver fibrosis is a dynamic wound-healing process associated with the deposition of extracellular matrix produced by myofibroblasts. HSCs activation, inflammation, oxidative stress, steatosis and aging play critical roles in the progression of liver fibrosis, which is correlated with the regulation of the peroxisome proliferator-activated receptor (PPAR) pathway. As nuclear receptors, PPARs reduce inflammatory response, regulate lipid metabolism, and inhibit fibrogenesis in the liver associated with aging. Thus, PPAR ligands have been investigated as possible therapeutic agents. Mounting evidence indicated that some PPAR agonists could reverse steatohepatitis and liver fibrosis. Consequently, targeting PPARs might be a promising and novel therapeutic option against liver fibrosis. This review summarizes recent studies on the role of PPARs on the pathogenesis and treatment of liver fibrosis." @default.
- W3111595544 created "2020-12-21" @default.
- W3111595544 creator A5070498523 @default.
- W3111595544 creator A5080203880 @default.
- W3111595544 creator A5083043424 @default.
- W3111595544 creator A5089869894 @default.
- W3111595544 date "2021-06-01" @default.
- W3111595544 modified "2023-10-16" @default.
- W3111595544 title "Peroxisome proliferator-activated receptors in the pathogenesis and therapies of liver fibrosis" @default.
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