FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111662021> ?p ?o ?g. }

• W3111662021 abstract "Abstract Background Research on non‐invasive methods of modulating age‐associated cognitive decline has yielded promising results. Current evidence shows that transcranial direct current stimulation (tDCS), if administered with concurrent cognitive training, may successfully modulate cognitive performance. In the TrainStim‐Cog trial, we investigated in healthy older adults if longer‐term training combined with tDCS, versus sham, would lead to higher increases in performance on the trained tasks, and to larger transfer to non‐trained domains. Moreover, we aimed to elucidate neural mechanisms underlying these effects. Method Fifty‐six participants (20 men; mean age / SD = 69.8 / 4.0 yrs) underwent nine sessions of cognitive training over a period of three weeks with concurrent administration of either tDCS stimulation over 20 min (1mA current) or sham stimulation. The cognitive training consisted of two tasks targeting executive functions: a letter‐updating task was used to train working memory updating and, reward‐based decision‐making was trained with a three‐stage Markov decision‐making task. Prior to the intervention and immediately after the intervention, performance on training and transfer tasks was assessed and neural correlates were recorded using structural, functional and diffusion tensor MRI. Result At the time of submitting this abstract, assessment of primary endpoint has just been completed; data base lock, and unblinding of intervention type will be conducted in February 2020. The trial has been registered at clinicaltrials.gov (ID NCT03838211), the study protocol of the trial has been published (Antonenko et al., 2019, Frontiers in Aging Neuroscience), and a statistical analysis plan has been uploaded at clinicaltrials.gov. Results of the analyses will be presented at the AAIC conference. Conclusion Our results will determine if a 3‐week combined cognitive training and tDCS approach may not only enhance trained functions, but also transfer to non‐trained tasks. Moreover, we will determine if effects are sustained over longer periods of time, and we will aim to identify predictors of response to the intervention on the individual level. Thus, our trial will hopefully contribute to the development of non‐medical interventions in the field of age‐associated cognitive decline." @default.
• W3111662021 created "2020-12-21" @default.
• W3111662021 creator A5021507597 @default.
• W3111662021 creator A5041380550 @default.
• W3111662021 creator A5059687755 @default.
• W3111662021 creator A5069959120 @default.
• W3111662021 date "2020-12-01" @default.
• W3111662021 modified "2023-09-26" @default.
• W3111662021 title "Effects of a multi‐session cognitive training combined with brain stimulation on age‐associated cognitive decline" @default.
• W3111662021 doi "https://doi.org/10.1002/alz.043209" @default.
• W3111662021 hasPublicationYear "2020" @default.
• W3111662021 type Work @default.
• W3111662021 sameAs 3111662021 @default.
• W3111662021 citedByCount "0" @default.
• W3111662021 crossrefType "journal-article" @default.
• W3111662021 hasAuthorship W3111662021A5021507597 @default.
• W3111662021 hasAuthorship W3111662021A5041380550 @default.
• W3111662021 hasAuthorship W3111662021A5059687755 @default.
• W3111662021 hasAuthorship W3111662021A5069959120 @default.
• W3111662021 hasBestOaLocation W31116620211 @default.
• W3111662021 hasConcept C119653847 @default.
• W3111662021 hasConcept C126322002 @default.
• W3111662021 hasConcept C15744967 @default.
• W3111662021 hasConcept C168563851 @default.
• W3111662021 hasConcept C169760540 @default.
• W3111662021 hasConcept C169900460 @default.
• W3111662021 hasConcept C185711340 @default.
• W3111662021 hasConcept C24998067 @default.
• W3111662021 hasConcept C2775968953 @default.
• W3111662021 hasConcept C2777803708 @default.
• W3111662021 hasConcept C2779134260 @default.
• W3111662021 hasConcept C2779483572 @default.
• W3111662021 hasConcept C2779602242 @default.
• W3111662021 hasConcept C2984863031 @default.
• W3111662021 hasConcept C2985799443 @default.
• W3111662021 hasConcept C548259974 @default.
• W3111662021 hasConcept C71924100 @default.
• W3111662021 hasConcept C99508421 @default.
• W3111662021 hasConceptScore W3111662021C119653847 @default.
• W3111662021 hasConceptScore W3111662021C126322002 @default.
• W3111662021 hasConceptScore W3111662021C15744967 @default.
• W3111662021 hasConceptScore W3111662021C168563851 @default.
• W3111662021 hasConceptScore W3111662021C169760540 @default.
• W3111662021 hasConceptScore W3111662021C169900460 @default.
• W3111662021 hasConceptScore W3111662021C185711340 @default.
• W3111662021 hasConceptScore W3111662021C24998067 @default.
• W3111662021 hasConceptScore W3111662021C2775968953 @default.
• W3111662021 hasConceptScore W3111662021C2777803708 @default.
• W3111662021 hasConceptScore W3111662021C2779134260 @default.
• W3111662021 hasConceptScore W3111662021C2779483572 @default.
• W3111662021 hasConceptScore W3111662021C2779602242 @default.
• W3111662021 hasConceptScore W3111662021C2984863031 @default.
• W3111662021 hasConceptScore W3111662021C2985799443 @default.
• W3111662021 hasConceptScore W3111662021C548259974 @default.
• W3111662021 hasConceptScore W3111662021C71924100 @default.
• W3111662021 hasConceptScore W3111662021C99508421 @default.
• W3111662021 hasIssue "S10" @default.
• W3111662021 hasLocation W31116620211 @default.
• W3111662021 hasOpenAccess W3111662021 @default.
• W3111662021 hasPrimaryLocation W31116620211 @default.
• W3111662021 hasRelatedWork W2087610926 @default.
• W3111662021 hasRelatedWork W2343266336 @default.
• W3111662021 hasRelatedWork W2588467107 @default.
• W3111662021 hasRelatedWork W2621721078 @default.
• W3111662021 hasRelatedWork W2725329196 @default.
• W3111662021 hasRelatedWork W4286472066 @default.
• W3111662021 hasRelatedWork W4296887696 @default.
• W3111662021 hasRelatedWork W4304161204 @default.
• W3111662021 hasRelatedWork W4308034631 @default.
• W3111662021 hasRelatedWork W4315929080 @default.
• W3111662021 hasVolume "16" @default.
• W3111662021 isParatext "false" @default.
• W3111662021 isRetracted "false" @default.
• W3111662021 magId "3111662021" @default.
• W3111662021 workType "article" @default.