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- W311166373 abstract "Vasospasm is a major cause of cerebrovascular diseases. Hyperhomocysteinemia exacerbates stroke in part by increasing oxidative stress and vascular remodeling. Cystathionine βsynthase heterozygous (CBS -/+) mice develop high level of Hcy. Tetra hydro curcumin (THC) polyphenolic compound from plant Curcuma longa, is a commonly used remedies. Present study determines the effect of THC in hyperhomocysteinemic mice after an ischemia episode. There were six groups of mice: WT, WT/Ischemia, WT/Ischemia treated THC, CBS (-/+), CBS (-/+)/Ischemic and CBS (-/+)/Ischemic treated THC. Middle cerebral Artery Occlusion (MCAO) was performed for 1 hour. After 24 hours, mice were injected with THC (300mg/kg) I.P. The Infarct area (IA) was assessed using TTC stain. Real Time PCR, Immunohistchemistry and Western blot were used to determine the expression of SOD-I, SOD-II, Phospho 22, Phospho 47. Neurological assessments were done in above group. The Electrophoretic Mobility Shift Assay (EMSA) was performed using NF-kappa B probe. The result suggested THC significantly decreases IA and oxidative damage in Ischemic mice. The EMSA result suggest that there was significant decrease in the NF-kappa B binding interaction to protein. In addition, there was significant improvement in neurological behavior in THC treated ischemic mice compared to Ischemic groups." @default.
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- W311166373 date "2009-04-01" @default.
- W311166373 modified "2023-09-26" @default.
- W311166373 title "Cerebroprotective role of Tetrahydro Curcumin in hyperhomocysteinemic ischemic mice by regulating NF‐kappa B" @default.
- W311166373 doi "https://doi.org/10.1096/fasebj.23.1_supplement.614.7" @default.
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