FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111684966> ?p ?o ?g. }

• W3111684966 endingPage "1479" @default.
• W3111684966 startingPage "1470" @default.
• W3111684966 abstract "In present work, a correlationship among quantitative drug-polymer miscibility, molecular relaxation and phase behavior of the dipyridamole (DPD) amorphous solid dispersions (ASDs), prepared with co-povidone (CP), hydroxypropyl methylcellulose phthalate (HPMC P) and hydroxypropyl methylcellulose acetate succinate (HPMC AS) has been investigated. Miscibility predicted using melting point depression approach for DPD with CP, HPMC P and HPMC AS at 25 °C was 0.93% w/w, 0.55% w/w and 0.40% w/w, respectively. Stretched relaxation time (τβ) for DPD ASDs, measured using modulated differential scanning calorimetry (MDSC) at common degree of undercooling, was in the order of DPD- CP > DPD-HPMC P > DPD-HPMC AS ASDs. Phase behavior of 12 months aged (25 ± 5 °C and 0% RH) spray dried 60% w/w ASDs was tracked using MDSC. Initial ASD samples had homogeneous phase revealed by single glass transition temperature (Tg) in the MDSC. MDSC study of aged ASDs revealed single-phase DPD-CP ASD, amorphous-amorphous and amorphous-crystalline phase separated DPD-HPMC P and DPD-HPMC AS ASDs, respectively. The results were supported by X-ray micro computed tomography and confocal laser scanning microscopy studies. This study demonstrated a profound influence of drug-polymer miscibility on molecular mobility and phase behavior of ASDs. This knowledge can help in designing “physical stable” ASDs." @default.
• W3111684966 created "2020-12-21" @default.
• W3111684966 creator A5021589637 @default.
• W3111684966 creator A5029346386 @default.
• W3111684966 creator A5075631860 @default.
• W3111684966 creator A5087544485 @default.
• W3111684966 date "2021-04-01" @default.
• W3111684966 modified "2023-10-10" @default.
• W3111684966 title "Correlationship of Drug-Polymer Miscibility, Molecular Relaxation and Phase Behavior of Dipyridamole Amorphous Solid Dispersions" @default.
• W3111684966 cites W1014687656 @default.
• W3111684966 cites W1060565426 @default.
• W3111684966 cites W1541736117 @default.
• W3111684966 cites W1895272437 @default.
• W3111684966 cites W1965028792 @default.
• W3111684966 cites W1967843190 @default.
• W3111684966 cites W1990521308 @default.
• W3111684966 cites W1994893251 @default.
• W3111684966 cites W2013199189 @default.
• W3111684966 cites W2030290307 @default.
• W3111684966 cites W2042599300 @default.
• W3111684966 cites W2044146593 @default.
• W3111684966 cites W2056491432 @default.
• W3111684966 cites W2069804811 @default.
• W3111684966 cites W2093947851 @default.
• W3111684966 cites W2094263699 @default.
• W3111684966 cites W2095916642 @default.
• W3111684966 cites W2101861157 @default.
• W3111684966 cites W2106504322 @default.
• W3111684966 cites W2148031361 @default.
• W3111684966 cites W2318545873 @default.
• W3111684966 cites W2321981907 @default.
• W3111684966 cites W2423995248 @default.
• W3111684966 cites W2467014326 @default.
• W3111684966 cites W2528205605 @default.
• W3111684966 cites W2607807275 @default.
• W3111684966 cites W2759450909 @default.
• W3111684966 cites W2760978385 @default.
• W3111684966 cites W2784170356 @default.
• W3111684966 cites W41119059 @default.
• W3111684966 cites W4243317274 @default.
• W3111684966 cites W4292101282 @default.
• W3111684966 doi "https://doi.org/10.1016/j.xphs.2020.12.007" @default.
• W3111684966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33333143" @default.
• W3111684966 hasPublicationYear "2021" @default.
• W3111684966 type Work @default.
• W3111684966 sameAs 3111684966 @default.
• W3111684966 citedByCount "6" @default.
• W3111684966 countsByYear W31116849662021 @default.
• W3111684966 countsByYear W31116849662022 @default.
• W3111684966 countsByYear W31116849662023 @default.
• W3111684966 crossrefType "journal-article" @default.
• W3111684966 hasAuthorship W3111684966A5021589637 @default.
• W3111684966 hasAuthorship W3111684966A5029346386 @default.
• W3111684966 hasAuthorship W3111684966A5075631860 @default.
• W3111684966 hasAuthorship W3111684966A5087544485 @default.
• W3111684966 hasBestOaLocation W31116849661 @default.
• W3111684966 hasConcept C101335993 @default.
• W3111684966 hasConcept C110884469 @default.
• W3111684966 hasConcept C112964491 @default.
• W3111684966 hasConcept C121332964 @default.
• W3111684966 hasConcept C122865956 @default.
• W3111684966 hasConcept C127413603 @default.
• W3111684966 hasConcept C13530604 @default.
• W3111684966 hasConcept C15920480 @default.
• W3111684966 hasConcept C159985019 @default.
• W3111684966 hasConcept C178790620 @default.
• W3111684966 hasConcept C185592680 @default.
• W3111684966 hasConcept C192562407 @default.
• W3111684966 hasConcept C21582691 @default.
• W3111684966 hasConcept C39519442 @default.
• W3111684966 hasConcept C42360764 @default.
• W3111684966 hasConcept C44280652 @default.
• W3111684966 hasConcept C521977710 @default.
• W3111684966 hasConcept C56052488 @default.
• W3111684966 hasConcept C97355855 @default.
• W3111684966 hasConceptScore W3111684966C101335993 @default.
• W3111684966 hasConceptScore W3111684966C110884469 @default.
• W3111684966 hasConceptScore W3111684966C112964491 @default.
• W3111684966 hasConceptScore W3111684966C121332964 @default.
• W3111684966 hasConceptScore W3111684966C122865956 @default.
• W3111684966 hasConceptScore W3111684966C127413603 @default.
• W3111684966 hasConceptScore W3111684966C13530604 @default.
• W3111684966 hasConceptScore W3111684966C15920480 @default.
• W3111684966 hasConceptScore W3111684966C159985019 @default.
• W3111684966 hasConceptScore W3111684966C178790620 @default.
• W3111684966 hasConceptScore W3111684966C185592680 @default.
• W3111684966 hasConceptScore W3111684966C192562407 @default.
• W3111684966 hasConceptScore W3111684966C21582691 @default.
• W3111684966 hasConceptScore W3111684966C39519442 @default.
• W3111684966 hasConceptScore W3111684966C42360764 @default.
• W3111684966 hasConceptScore W3111684966C44280652 @default.
• W3111684966 hasConceptScore W3111684966C521977710 @default.
• W3111684966 hasConceptScore W3111684966C56052488 @default.
• W3111684966 hasConceptScore W3111684966C97355855 @default.
• W3111684966 hasIssue "4" @default.
• W3111684966 hasLocation W31116849661 @default.
• W3111684966 hasOpenAccess W3111684966 @default.
• W3111684966 hasPrimaryLocation W31116849661 @default.

• next