Matches in SemOpenAlex for { <https://semopenalex.org/work/W31117504> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W31117504 endingPage "232" @default.
- W31117504 startingPage "229" @default.
- W31117504 abstract "Polyphosphate is a polymer of phosphate residues linked by high energy phosphoanhydride bonds. Despite being highly conserved throughout nature, its function is poorly understood. Here we show that Dictyostelium cells accumulate extracellular polyphosphate, and this acts to inhibit proliferation at high cell densities. In shaking culture, extracellular polyphosphate concentrations increase as cell density increases, and if the concentration of polyphosphate observed at the stationary phase is added to cells at mid-log, proliferation is halted. Adding an exopolyphosphatase to cell cultures or stationary phase conditioned medium decreases polyphosphate levels and abrogates the anti-proliferative effect. The cells show saturable binding of polyphosphate, suggesting the presence of a cell surface polyphosphate receptor. Extracellular polyphosphate accumulation is potentiated by decreased nutrient levels, potentially as a means to anticipate starvation. Loss of the Dictyostelium polyphosphate kinase DdPpk1 causes intracellular polyphosphate levels to become undetectable and negatively affects fitness, cytokinesis, and germination. However, cells lacking DdPpk1 accumulate ∼50% normal levels of extracellular polyphosphate, suggesting an additional means of synthesis. We found that cells lacking inositol hexakisphosphate kinase, which is responsible for the synthesis of the inositol pyrophosphates IP7 and IP8, reach abnormally high cell densities and show decreased extracellular polyphosphate levels. Two different enzymes thus appear to mediate the synthesis of Dictyostelium extracellular polyphosphate, which is used as a signal in an autocrine negative feedback loop to regulate cell proliferation." @default.
- W31117504 created "2016-06-24" @default.
- W31117504 creator A5037075115 @default.
- W31117504 date "1956-08-01" @default.
- W31117504 modified "2023-09-27" @default.
- W31117504 title "A principle of auto-regulation of growth" @default.
- W31117504 cites W2094561750 @default.
- W31117504 cites W2142365708 @default.
- W31117504 doi "https://doi.org/10.1016/0014-4827(56)90212-9" @default.
- W31117504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13356849" @default.
- W31117504 hasPublicationYear "1956" @default.
- W31117504 type Work @default.
- W31117504 sameAs 31117504 @default.
- W31117504 citedByCount "150" @default.
- W31117504 countsByYear W311175042014 @default.
- W31117504 countsByYear W311175042016 @default.
- W31117504 crossrefType "journal-article" @default.
- W31117504 hasAuthorship W31117504A5037075115 @default.
- W31117504 hasConcept C104317684 @default.
- W31117504 hasConcept C170493617 @default.
- W31117504 hasConcept C2775969001 @default.
- W31117504 hasConcept C2777132085 @default.
- W31117504 hasConcept C2777427919 @default.
- W31117504 hasConcept C2778038992 @default.
- W31117504 hasConcept C28406088 @default.
- W31117504 hasConcept C55493867 @default.
- W31117504 hasConcept C79879829 @default.
- W31117504 hasConcept C86803240 @default.
- W31117504 hasConcept C95444343 @default.
- W31117504 hasConceptScore W31117504C104317684 @default.
- W31117504 hasConceptScore W31117504C170493617 @default.
- W31117504 hasConceptScore W31117504C2775969001 @default.
- W31117504 hasConceptScore W31117504C2777132085 @default.
- W31117504 hasConceptScore W31117504C2777427919 @default.
- W31117504 hasConceptScore W31117504C2778038992 @default.
- W31117504 hasConceptScore W31117504C28406088 @default.
- W31117504 hasConceptScore W31117504C55493867 @default.
- W31117504 hasConceptScore W31117504C79879829 @default.
- W31117504 hasConceptScore W31117504C86803240 @default.
- W31117504 hasConceptScore W31117504C95444343 @default.
- W31117504 hasIssue "1" @default.
- W31117504 hasLocation W311175041 @default.
- W31117504 hasLocation W311175042 @default.
- W31117504 hasOpenAccess W31117504 @default.
- W31117504 hasPrimaryLocation W311175041 @default.
- W31117504 hasRelatedWork W1970082812 @default.
- W31117504 hasRelatedWork W2000021088 @default.
- W31117504 hasRelatedWork W2028136526 @default.
- W31117504 hasRelatedWork W2086954797 @default.
- W31117504 hasRelatedWork W2144615232 @default.
- W31117504 hasRelatedWork W2584642152 @default.
- W31117504 hasRelatedWork W2916455157 @default.
- W31117504 hasRelatedWork W2990996515 @default.
- W31117504 hasRelatedWork W3110486933 @default.
- W31117504 hasRelatedWork W3213186987 @default.
- W31117504 hasVolume "11" @default.
- W31117504 isParatext "false" @default.
- W31117504 isRetracted "false" @default.
- W31117504 magId "31117504" @default.
- W31117504 workType "article" @default.