Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111751027> ?p ?o ?g. }
- W3111751027 abstract "Malignant pleural mesothelioma (MPM) is strongly associated with occupational or environmental asbestos exposure and arises from neoplastic transformation of mesothelial cells in the pleural cavity. The only standard initial treatment for unresectable MPM is combination chemotherapy with cisplatin (CDDP) and pemetrexed (PEM). Further, CDDP/PEM is the only approved regimen with evidence of prolonged overall survival (OS), although the median OS for patients treated with this regimen is only 12 months after diagnosis. Thus, the development of new therapeutic strategies has been investigated for approximately 20 years. In contrast to recent advances in personalized lung cancer therapies, diagnostic and prognostic biomarker research has just started in mesothelioma. Epigenetic alterations include DNA methylation, histone modifications, and other chromatin-remodeling events. These processes are involved in numerous cellular processes including differentiation, development, and tumorigenesis. Epigenetic modifications play an important role in gene expression and regulation related to malignant MPM phenotypes and histological subtypes. An immune checkpoint PD-1 inhibitor, nivolumab, was approved as second-line therapy for patients who had failed initial chemotherapy, based on the results of the MERIT study. Various clinical immunotherapy trials are ongoing in patients with advanced MPM. In this review, we describe recent knowledge on epigenetic alterations, which might identify candidate therapeutic targets and immunotherapeutic regimens under development for MPM." @default.
- W3111751027 created "2020-12-21" @default.
- W3111751027 creator A5007136335 @default.
- W3111751027 creator A5023719583 @default.
- W3111751027 creator A5036631208 @default.
- W3111751027 creator A5052144423 @default.
- W3111751027 creator A5064231127 @default.
- W3111751027 date "2020-12-14" @default.
- W3111751027 modified "2023-10-14" @default.
- W3111751027 title "Epigenetic Alterations and Biomarkers for Immune Checkpoint Inhibitors–Current Standards and Future Perspectives in Malignant Pleural Mesothelioma Treatment" @default.
- W3111751027 cites W1504023721 @default.
- W3111751027 cites W1511815964 @default.
- W3111751027 cites W1517335907 @default.
- W3111751027 cites W1606625034 @default.
- W3111751027 cites W1980807804 @default.
- W3111751027 cites W1993733508 @default.
- W3111751027 cites W1994993231 @default.
- W3111751027 cites W1995160678 @default.
- W3111751027 cites W2001673920 @default.
- W3111751027 cites W2006752813 @default.
- W3111751027 cites W2007265317 @default.
- W3111751027 cites W2007541023 @default.
- W3111751027 cites W2009858080 @default.
- W3111751027 cites W2034042626 @default.
- W3111751027 cites W2048425382 @default.
- W3111751027 cites W2062952095 @default.
- W3111751027 cites W2063886011 @default.
- W3111751027 cites W2070195376 @default.
- W3111751027 cites W2070777085 @default.
- W3111751027 cites W2070896470 @default.
- W3111751027 cites W2071818162 @default.
- W3111751027 cites W2074699765 @default.
- W3111751027 cites W2084203180 @default.
- W3111751027 cites W2084748297 @default.
- W3111751027 cites W2092243048 @default.
- W3111751027 cites W2102627969 @default.
- W3111751027 cites W2108196925 @default.
- W3111751027 cites W2112728955 @default.
- W3111751027 cites W2113035823 @default.
- W3111751027 cites W2119079421 @default.
- W3111751027 cites W2123301270 @default.
- W3111751027 cites W2124505866 @default.
- W3111751027 cites W2127180680 @default.
- W3111751027 cites W2130085343 @default.
- W3111751027 cites W2151516456 @default.
- W3111751027 cites W2169012257 @default.
- W3111751027 cites W2215044613 @default.
- W3111751027 cites W2254928933 @default.
- W3111751027 cites W2291531085 @default.
- W3111751027 cites W2403874820 @default.
- W3111751027 cites W2433015972 @default.
- W3111751027 cites W2460529418 @default.
- W3111751027 cites W2502703983 @default.
- W3111751027 cites W2527738828 @default.
- W3111751027 cites W2556189512 @default.
- W3111751027 cites W2593193817 @default.
- W3111751027 cites W2594793697 @default.
- W3111751027 cites W2607870376 @default.
- W3111751027 cites W2614855056 @default.
- W3111751027 cites W2625172095 @default.
- W3111751027 cites W2698245864 @default.
- W3111751027 cites W2724336500 @default.
- W3111751027 cites W2751143162 @default.
- W3111751027 cites W2758662017 @default.
- W3111751027 cites W2760942750 @default.
- W3111751027 cites W2792186276 @default.
- W3111751027 cites W2792541584 @default.
- W3111751027 cites W2801062708 @default.
- W3111751027 cites W2808133785 @default.
- W3111751027 cites W2884930092 @default.
- W3111751027 cites W2889252569 @default.
- W3111751027 cites W2897299514 @default.
- W3111751027 cites W2897816153 @default.
- W3111751027 cites W2900252393 @default.
- W3111751027 cites W2905866451 @default.
- W3111751027 cites W2908887190 @default.
- W3111751027 cites W2909198142 @default.
- W3111751027 cites W2913079755 @default.
- W3111751027 cites W2924341172 @default.
- W3111751027 cites W2948619068 @default.
- W3111751027 cites W2977339506 @default.
- W3111751027 cites W2979304978 @default.
- W3111751027 cites W2999183644 @default.
- W3111751027 cites W3014512949 @default.
- W3111751027 cites W3081696843 @default.
- W3111751027 cites W4211134618 @default.
- W3111751027 doi "https://doi.org/10.3389/fonc.2020.554570" @default.
- W3111751027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7767988" @default.
- W3111751027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33381446" @default.
- W3111751027 hasPublicationYear "2020" @default.
- W3111751027 type Work @default.
- W3111751027 sameAs 3111751027 @default.
- W3111751027 citedByCount "15" @default.
- W3111751027 countsByYear W31117510272021 @default.
- W3111751027 countsByYear W31117510272022 @default.
- W3111751027 countsByYear W31117510272023 @default.
- W3111751027 crossrefType "journal-article" @default.
- W3111751027 hasAuthorship W3111751027A5007136335 @default.
- W3111751027 hasAuthorship W3111751027A5023719583 @default.
- W3111751027 hasAuthorship W3111751027A5036631208 @default.