Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111756039> ?p ?o ?g. }
- W3111756039 abstract "The ever-increasing morbidity and mortality of clear cell renal cell carcinoma (ccRCC) urgently demands updated biomarkers. MicroRNAs (miRNAs) are involved in diverse biological processes such as cell proliferation, differentiation, apoptosis by regulating their target genes’ expression. In kidney cancers, miRNAs have been reported to be involved in tumorigenesis and to be the diagnostic, prognostic, and therapeutic response biomarkers. Here, we performed a systematic analysis for ccRCC-related miRNAs as biomarkers by searching keywords in the NCBI PubMed database and found 118 miRNAs as diagnostic biomarkers, 28 miRNAs as prognostic biomarkers, and 80 miRNAs as therapeutic biomarkers in ccRCC. miRNA-21, miRNA-155, miRNA-141, miRNA-126, and miRNA-221, as significantly differentially expressed miRNAs between cancer and normal tissues, play extensive roles in the cell proliferation, differentiation, apoptosis of ccRCC. GO and KEGG enrichment analysis of these miRNAs’ target genes through Metascape showed these target genes are enriched in Protein Domain Specific Binding (GO:0019904). In this paper, we identified highly specific miRNAs in the pathogenesis of ccRCC and explored their potential applications for diagnosis, prognosis, and treatment of ccRCC." @default.
- W3111756039 created "2020-12-21" @default.
- W3111756039 creator A5025645003 @default.
- W3111756039 creator A5030756396 @default.
- W3111756039 creator A5040528301 @default.
- W3111756039 creator A5044757881 @default.
- W3111756039 creator A5049871496 @default.
- W3111756039 creator A5054161386 @default.
- W3111756039 creator A5057633505 @default.
- W3111756039 creator A5060782448 @default.
- W3111756039 creator A5061541739 @default.
- W3111756039 creator A5061800239 @default.
- W3111756039 creator A5089731650 @default.
- W3111756039 date "2020-12-04" @default.
- W3111756039 modified "2023-09-24" @default.
- W3111756039 title "Systematic Analysis of microRNA Biomarkers for Diagnosis, Prognosis, and Therapy in Patients With Clear Cell Renal Cell Carcinoma" @default.
- W3111756039 cites W1482814115 @default.
- W3111756039 cites W1488872279 @default.
- W3111756039 cites W1887051713 @default.
- W3111756039 cites W1966756094 @default.
- W3111756039 cites W1979673666 @default.
- W3111756039 cites W1981994655 @default.
- W3111756039 cites W1983427659 @default.
- W3111756039 cites W1991966840 @default.
- W3111756039 cites W2018773842 @default.
- W3111756039 cites W2019257830 @default.
- W3111756039 cites W2019665202 @default.
- W3111756039 cites W2025849972 @default.
- W3111756039 cites W2035514852 @default.
- W3111756039 cites W2043317292 @default.
- W3111756039 cites W2043682963 @default.
- W3111756039 cites W2050388905 @default.
- W3111756039 cites W2071300544 @default.
- W3111756039 cites W2075232308 @default.
- W3111756039 cites W2083381199 @default.
- W3111756039 cites W2084872607 @default.
- W3111756039 cites W2103695171 @default.
- W3111756039 cites W2133658633 @default.
- W3111756039 cites W2149258280 @default.
- W3111756039 cites W2169194081 @default.
- W3111756039 cites W2171398108 @default.
- W3111756039 cites W2173254139 @default.
- W3111756039 cites W2185916789 @default.
- W3111756039 cites W2217427523 @default.
- W3111756039 cites W2261694353 @default.
- W3111756039 cites W2325971445 @default.
- W3111756039 cites W2405615126 @default.
- W3111756039 cites W2434814148 @default.
- W3111756039 cites W2468996569 @default.
- W3111756039 cites W2470061745 @default.
- W3111756039 cites W2475154450 @default.
- W3111756039 cites W2494502397 @default.
- W3111756039 cites W2511508398 @default.
- W3111756039 cites W2520078471 @default.
- W3111756039 cites W2520275427 @default.
- W3111756039 cites W2525259041 @default.
- W3111756039 cites W2529902280 @default.
- W3111756039 cites W2538955856 @default.
- W3111756039 cites W2566807314 @default.
- W3111756039 cites W2600896335 @default.
- W3111756039 cites W2619907255 @default.
- W3111756039 cites W2727623094 @default.
- W3111756039 cites W2731860601 @default.
- W3111756039 cites W2737198828 @default.
- W3111756039 cites W2753109313 @default.
- W3111756039 cites W2755735969 @default.
- W3111756039 cites W2755917368 @default.
- W3111756039 cites W2760403167 @default.
- W3111756039 cites W2762534624 @default.
- W3111756039 cites W2765982980 @default.
- W3111756039 cites W2766317396 @default.
- W3111756039 cites W2766963700 @default.
- W3111756039 cites W2769110348 @default.
- W3111756039 cites W2791597306 @default.
- W3111756039 cites W2797883881 @default.
- W3111756039 cites W2799427261 @default.
- W3111756039 cites W2801091429 @default.
- W3111756039 cites W2880398144 @default.
- W3111756039 cites W2886768388 @default.
- W3111756039 cites W2891680869 @default.
- W3111756039 cites W2898979195 @default.
- W3111756039 cites W2899600560 @default.
- W3111756039 cites W2901783992 @default.
- W3111756039 cites W2905403015 @default.
- W3111756039 cites W2912505956 @default.
- W3111756039 cites W2922068014 @default.
- W3111756039 cites W2928665623 @default.
- W3111756039 cites W2945755627 @default.
- W3111756039 cites W2950512766 @default.
- W3111756039 cites W2954329183 @default.
- W3111756039 cites W2964937844 @default.
- W3111756039 cites W2981583987 @default.
- W3111756039 cites W2981996370 @default.
- W3111756039 cites W2982512939 @default.
- W3111756039 doi "https://doi.org/10.3389/fonc.2020.543817" @default.
- W3111756039 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7746831" @default.
- W3111756039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33344224" @default.
- W3111756039 hasPublicationYear "2020" @default.
- W3111756039 type Work @default.
- W3111756039 sameAs 3111756039 @default.