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- W3111777582 endingPage "5980" @default.
- W3111777582 startingPage "5980" @default.
- W3111777582 abstract "Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity. PON1 and its isoforms play an important role in drug metabolism as well as in the prevention of cardiovascular and neurodegenerative diseases. Although all three members of the PON family have the same origin and very similar amino acid sequences, they have different functions and are found in different locations. PONs exhibit substrate promiscuity, and their true physiological substrates are still not known. However, possible substrates include homocysteine thiolactone, an analogue of natural quorum-sensing molecules, and the recently discovered derivatives of arachidonic acid—bioactive δ-lactones. Directed evolution, site-directed mutagenesis, and kinetic studies provide comprehensive insights into the active site and catalytic mechanism of PON1. However, there is still a whole world of mystery waiting to be discovered, which would elucidate the substrate promiscuity of a group of enzymes that are so similar in their evolution and sequence yet so distinct in their function." @default.
- W3111777582 created "2020-12-21" @default.
- W3111777582 creator A5030471735 @default.
- W3111777582 creator A5064969865 @default.
- W3111777582 creator A5071985176 @default.
- W3111777582 date "2020-12-17" @default.
- W3111777582 modified "2023-10-15" @default.
- W3111777582 title "The Structure and Function of Paraoxonase-1 and Its Comparison to Paraoxonase-2 and -3" @default.
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