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- W3111815842 abstract "Real-world bioelectronics applications, including drug delivery systems, biosensing and electrical modulation of tissues and organs, largely require biointerfaces at the macroscopic level. However, traditional macroscale bioelectronic electrodes usually exhibit invasive or power-inefficient architectures, inability to form uniform and subcellular interfaces, or faradaic reactions at electrode surfaces. Here, we develop a micelle-enabled self-assembly approach for a binder-free and carbon-based monolithic device, aimed at large-scale bioelectronic interfaces. The device incorporates a multi-scale porous material architecture, an interdigitated microelectrode layout and a supercapacitor-like performance. In cell training processes, we use the device to modulate the contraction rate of primary cardiomyocytes at the subcellular level to target frequency in vitro. We also achieve capacitive control of the electrophysiology in isolated hearts, retinal tissues and sciatic nerves, as well as bioelectronic cardiac sensing. Our results support the exploration of device platforms already used in energy research to identify new opportunities in bioelectronics." @default.
- W3111815842 created "2020-12-21" @default.
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- W3111815842 date "2020-12-07" @default.
- W3111815842 modified "2023-09-29" @default.
- W3111815842 title "Micelle-enabled self-assembly of porous and monolithic carbon membranes for bioelectronic interfaces" @default.
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- W3111815842 doi "https://doi.org/10.1038/s41565-020-00805-z" @default.
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