Matches in SemOpenAlex for { <https://semopenalex.org/work/W3111845194> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W3111845194 endingPage "181" @default.
- W3111845194 startingPage "176" @default.
- W3111845194 abstract "Objective Trastuzumab may convert human epidermal growth factor receptor-2 (HER2)-positive primary breast tumors to HER2-negative tumors after chemotherapy. This study determined whether trastuzumab increases the number of patients with conversion to HER2-negative status and assessed the effect of neoadjuvant chemotherapy. Methods We retrospectively reviewed 46 patients diagnosed with HER2-overexpression in primary breast cancers at Tokai University Hospital, receiving neoadjuvant chemotherapy by immunohistochemistry and fluorescence in situ hybridization (FISH). Surgical specimens of patients achieving less than pathological complete response (pCR) were verified for sufficient residual tissue to evaluate post-treatment HER2 status by dual-color in situ hybridization (DISH). Results pCR was achieved in 8 of the 46 (17.4%) patients. The residual tumor was sufficient for a ssessing post-treatment HER2 status in 25 patients. DISH of pretreatment specimens confirmed HER2 amplification prior to therapy. Of the 25 HER2-positive patients, DISH revealed 3 were HER2 negative in pretreatment specimens. No post-treatment tumors were HER2-negative according to DISH in HER2-positive pre-treatment tumors. Among HER2-negative pretreatment tumors, 1 post-treatment tumor was HER2 positive and 2 had stable HER2 status. Conclusion HER2 status determined by DISH was stable between pretreatment breast tumors and residual tumors. However, a small discrepancy regarding HER2 status determined by immunohistochemistry and DISH existed." @default.
- W3111845194 created "2020-12-21" @default.
- W3111845194 creator A5009141478 @default.
- W3111845194 creator A5012257419 @default.
- W3111845194 creator A5015450747 @default.
- W3111845194 creator A5062302046 @default.
- W3111845194 date "2020-12-20" @default.
- W3111845194 modified "2023-09-26" @default.
- W3111845194 title "Stability of HER2 Status by Dual-color in Situ Hybridization Before and After Neoadjuvant Chemotherapy in Breast Cancer." @default.
- W3111845194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33300587" @default.
- W3111845194 hasPublicationYear "2020" @default.
- W3111845194 type Work @default.
- W3111845194 sameAs 3111845194 @default.
- W3111845194 citedByCount "0" @default.
- W3111845194 crossrefType "journal-article" @default.
- W3111845194 hasAuthorship W3111845194A5009141478 @default.
- W3111845194 hasAuthorship W3111845194A5012257419 @default.
- W3111845194 hasAuthorship W3111845194A5015450747 @default.
- W3111845194 hasAuthorship W3111845194A5062302046 @default.
- W3111845194 hasConcept C104317684 @default.
- W3111845194 hasConcept C105580179 @default.
- W3111845194 hasConcept C121608353 @default.
- W3111845194 hasConcept C126322002 @default.
- W3111845194 hasConcept C142724271 @default.
- W3111845194 hasConcept C143998085 @default.
- W3111845194 hasConcept C204232928 @default.
- W3111845194 hasConcept C207886595 @default.
- W3111845194 hasConcept C2776694085 @default.
- W3111845194 hasConcept C2777542201 @default.
- W3111845194 hasConcept C2779786085 @default.
- W3111845194 hasConcept C2908728163 @default.
- W3111845194 hasConcept C30481170 @default.
- W3111845194 hasConcept C530470458 @default.
- W3111845194 hasConcept C55493867 @default.
- W3111845194 hasConcept C71924100 @default.
- W3111845194 hasConcept C81439078 @default.
- W3111845194 hasConcept C86803240 @default.
- W3111845194 hasConceptScore W3111845194C104317684 @default.
- W3111845194 hasConceptScore W3111845194C105580179 @default.
- W3111845194 hasConceptScore W3111845194C121608353 @default.
- W3111845194 hasConceptScore W3111845194C126322002 @default.
- W3111845194 hasConceptScore W3111845194C142724271 @default.
- W3111845194 hasConceptScore W3111845194C143998085 @default.
- W3111845194 hasConceptScore W3111845194C204232928 @default.
- W3111845194 hasConceptScore W3111845194C207886595 @default.
- W3111845194 hasConceptScore W3111845194C2776694085 @default.
- W3111845194 hasConceptScore W3111845194C2777542201 @default.
- W3111845194 hasConceptScore W3111845194C2779786085 @default.
- W3111845194 hasConceptScore W3111845194C2908728163 @default.
- W3111845194 hasConceptScore W3111845194C30481170 @default.
- W3111845194 hasConceptScore W3111845194C530470458 @default.
- W3111845194 hasConceptScore W3111845194C55493867 @default.
- W3111845194 hasConceptScore W3111845194C71924100 @default.
- W3111845194 hasConceptScore W3111845194C81439078 @default.
- W3111845194 hasConceptScore W3111845194C86803240 @default.
- W3111845194 hasIssue "4" @default.
- W3111845194 hasLocation W31118451941 @default.
- W3111845194 hasOpenAccess W3111845194 @default.
- W3111845194 hasPrimaryLocation W31118451941 @default.
- W3111845194 hasRelatedWork W1969719189 @default.
- W3111845194 hasRelatedWork W1979021257 @default.
- W3111845194 hasRelatedWork W2023068871 @default.
- W3111845194 hasRelatedWork W2040069802 @default.
- W3111845194 hasRelatedWork W2109402856 @default.
- W3111845194 hasRelatedWork W2126231395 @default.
- W3111845194 hasRelatedWork W2191617550 @default.
- W3111845194 hasRelatedWork W2241466075 @default.
- W3111845194 hasRelatedWork W2403411638 @default.
- W3111845194 hasRelatedWork W2586775279 @default.
- W3111845194 hasRelatedWork W2600572835 @default.
- W3111845194 hasRelatedWork W2624795029 @default.
- W3111845194 hasRelatedWork W2726752938 @default.
- W3111845194 hasRelatedWork W2736229798 @default.
- W3111845194 hasRelatedWork W2803984949 @default.
- W3111845194 hasRelatedWork W2897257953 @default.
- W3111845194 hasRelatedWork W2932188375 @default.
- W3111845194 hasRelatedWork W2954662492 @default.
- W3111845194 hasRelatedWork W2978294735 @default.
- W3111845194 hasRelatedWork W2990659181 @default.
- W3111845194 hasVolume "45" @default.
- W3111845194 isParatext "false" @default.
- W3111845194 isRetracted "false" @default.
- W3111845194 magId "3111845194" @default.
- W3111845194 workType "article" @default.